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Q4VC05 (BCL7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell CLL/lymphoma 7 protein family member A
Gene names
Name:BCL7A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Involvement in disease

Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.

Sequence similarities

Belongs to the BCL7 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4VC05-1)

Also known as: Isoform b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4VC05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: Q → QVPRSRSQRGSQIGREPIGLSG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210B-cell CLL/lymphoma 7 protein family member A
PRO_0000239823

Amino acid modifications

Modified residue2031Phosphoserine Ref.5
Modified residue2071Phosphoserine Ref.5

Natural variations

Alternative sequence1871Q → QVPRSRSQRGSQIGREPIGL SG in isoform 2.
VSP_019271
Natural variant1201N → T.
Corresponds to variant rs34821485 [ dbSNP | Ensembl ].
VAR_033539

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Isoform b) [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 4AB4AC3B309ADDB8

FASTA21022,810
        10         20         30         40         50         60 
MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP VTEPKVDDKN 

        70         80         90        100        110        120 
KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA DASPIKQENS SNSSPAPEPN 

       130        140        150        160        170        180 
SAVPSDGTEA KVDEAQADGK EHPGAEDASD EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA 

       190        200        210 
ETSAISQDLE GVPPSKKMKL EASQQNSEEM 

« Hide

Isoform 2 [UniParc].

Checksum: 48B6CD8004914602
Show »

FASTA23125,029

References

« Hide 'large scale' references
[1]"Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon."
Zani V.J., Asou N., Jadayel D., Heward J.M., Shipley J., Nacheva E., Takasuki K., Catovsky D., Dyer M.J.S.
Blood 87:3124-3134(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney and Thalamus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[5]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89984 mRNA. Translation: CAA62011.1.
AK296159 mRNA. Translation: BAG58898.1.
AK316486 mRNA. Translation: BAH14857.1.
CH471054 Genomic DNA. Translation: EAW98302.1.
BC094723 mRNA. Translation: AAH94723.1.
BC113627 mRNA. Translation: AAI13628.1.
CCDSCCDS53841.1. [Q4VC05-1]
CCDS9226.1. [Q4VC05-2]
PIRS58245. S58237.
RefSeqNP_001019979.1. NM_001024808.1. [Q4VC05-1]
NP_066273.1. NM_020993.3. [Q4VC05-2]
UniGeneHs.530970.

3D structure databases

ProteinModelPortalQ4VC05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107077. 8 interactions.
DIPDIP-27608N.
IntActQ4VC05. 3 interactions.
MINTMINT-1133208.
STRING9606.ENSP00000261822.

PTM databases

PhosphoSiteQ4VC05.

Polymorphism databases

DMDM74754614.

Proteomic databases

MaxQBQ4VC05.
PaxDbQ4VC05.
PRIDEQ4VC05.

Protocols and materials databases

DNASU605.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261822; ENSP00000261822; ENSG00000110987. [Q4VC05-1]
ENST00000538010; ENSP00000445868; ENSG00000110987. [Q4VC05-2]
GeneID605.
KEGGhsa:605.
UCSCuc001ubo.3. human. [Q4VC05-2]
uc001ubp.3. human. [Q4VC05-1]

Organism-specific databases

CTD605.
GeneCardsGC12P122459.
HGNCHGNC:1004. BCL7A.
HPAHPA019762.
MIM601406. gene.
neXtProtNX_Q4VC05.
PharmGKBPA25314.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285788.
HOGENOMHOG000232196.
HOVERGENHBG008481.
InParanoidQ4VC05.
OMAEPKVDDV.
OrthoDBEOG7GQXWV.
PhylomeDBQ4VC05.
TreeFamTF317441.

Gene expression databases

BgeeQ4VC05.
CleanExHS_BCL7A.
GenevestigatorQ4VC05.

Family and domain databases

InterProIPR006804. BCL7.
[Graphical view]
PANTHERPTHR12767. PTHR12767. 1 hit.
PfamPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi605.
NextBio2459.
PROQ4VC05.
SOURCESearch...

Entry information

Entry nameBCL7A_HUMAN
AccessionPrimary (citable) accession number: Q4VC05
Secondary accession number(s): B4DJN6 expand/collapse secondary AC list , B7ZB21, Q13843, Q14CT7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM