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Q4VC05

- BCL7A_HUMAN

UniProt

Q4VC05 - BCL7A_HUMAN

Protein

B-cell CLL/lymphoma 7 protein family member A

Gene

BCL7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member A
    Gene namesi
    Name:BCL7A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1004. BCL7A.

    Pathology & Biotechi

    Involvement in diseasei

    Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.

    Organism-specific databases

    PharmGKBiPA25314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210B-cell CLL/lymphoma 7 protein family member APRO_0000239823Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei203 – 2031Phosphoserine1 Publication
    Modified residuei207 – 2071Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ4VC05.
    PaxDbiQ4VC05.
    PRIDEiQ4VC05.

    PTM databases

    PhosphoSiteiQ4VC05.

    Expressioni

    Gene expression databases

    BgeeiQ4VC05.
    CleanExiHS_BCL7A.
    GenevestigatoriQ4VC05.

    Organism-specific databases

    HPAiHPA019762.

    Interactioni

    Protein-protein interaction databases

    BioGridi107077. 8 interactions.
    DIPiDIP-27608N.
    IntActiQ4VC05. 3 interactions.
    MINTiMINT-1133208.
    STRINGi9606.ENSP00000261822.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4VC05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BCL7 family.Curated

    Phylogenomic databases

    eggNOGiNOG285788.
    HOGENOMiHOG000232196.
    HOVERGENiHBG008481.
    InParanoidiQ4VC05.
    OMAiEPKVDDV.
    OrthoDBiEOG7GQXWV.
    PhylomeDBiQ4VC05.
    TreeFamiTF317441.

    Family and domain databases

    InterProiIPR006804. BCL7.
    [Graphical view]
    PANTHERiPTHR12767. PTHR12767. 1 hit.
    PfamiPF04714. BCL_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4VC05-1) [UniParc]FASTAAdd to Basket

    Also known as: Isoform b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP    50
    VTEPKVDDKN KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA 100
    DASPIKQENS SNSSPAPEPN SAVPSDGTEA KVDEAQADGK EHPGAEDASD 150
    EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA ETSAISQDLE GVPPSKKMKL 200
    EASQQNSEEM 210
    Length:210
    Mass (Da):22,810
    Last modified:July 5, 2005 - v1
    Checksum:i4AB4AC3B309ADDB8
    GO
    Isoform 2 (identifier: Q4VC05-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-187: Q → QVPRSRSQRGSQIGREPIGLSG

    Show »
    Length:231
    Mass (Da):25,029
    Checksum:i48B6CD8004914602
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201N → T.
    Corresponds to variant rs34821485 [ dbSNP | Ensembl ].
    VAR_033539

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 1871Q → QVPRSRSQRGSQIGREPIGL SG in isoform 2. 2 PublicationsVSP_019271

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89984 mRNA. Translation: CAA62011.1.
    AK296159 mRNA. Translation: BAG58898.1.
    AK316486 mRNA. Translation: BAH14857.1.
    CH471054 Genomic DNA. Translation: EAW98302.1.
    BC094723 mRNA. Translation: AAH94723.1.
    BC113627 mRNA. Translation: AAI13628.1.
    CCDSiCCDS53841.1. [Q4VC05-1]
    CCDS9226.1. [Q4VC05-2]
    PIRiS58237. S58245.
    RefSeqiNP_001019979.1. NM_001024808.1. [Q4VC05-1]
    NP_066273.1. NM_020993.3. [Q4VC05-2]
    UniGeneiHs.530970.

    Genome annotation databases

    EnsembliENST00000261822; ENSP00000261822; ENSG00000110987. [Q4VC05-1]
    ENST00000538010; ENSP00000445868; ENSG00000110987. [Q4VC05-2]
    GeneIDi605.
    KEGGihsa:605.
    UCSCiuc001ubo.3. human. [Q4VC05-2]
    uc001ubp.3. human. [Q4VC05-1]

    Polymorphism databases

    DMDMi74754614.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89984 mRNA. Translation: CAA62011.1 .
    AK296159 mRNA. Translation: BAG58898.1 .
    AK316486 mRNA. Translation: BAH14857.1 .
    CH471054 Genomic DNA. Translation: EAW98302.1 .
    BC094723 mRNA. Translation: AAH94723.1 .
    BC113627 mRNA. Translation: AAI13628.1 .
    CCDSi CCDS53841.1. [Q4VC05-1 ]
    CCDS9226.1. [Q4VC05-2 ]
    PIRi S58237. S58245.
    RefSeqi NP_001019979.1. NM_001024808.1. [Q4VC05-1 ]
    NP_066273.1. NM_020993.3. [Q4VC05-2 ]
    UniGenei Hs.530970.

    3D structure databases

    ProteinModelPortali Q4VC05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107077. 8 interactions.
    DIPi DIP-27608N.
    IntActi Q4VC05. 3 interactions.
    MINTi MINT-1133208.
    STRINGi 9606.ENSP00000261822.

    PTM databases

    PhosphoSitei Q4VC05.

    Polymorphism databases

    DMDMi 74754614.

    Proteomic databases

    MaxQBi Q4VC05.
    PaxDbi Q4VC05.
    PRIDEi Q4VC05.

    Protocols and materials databases

    DNASUi 605.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261822 ; ENSP00000261822 ; ENSG00000110987 . [Q4VC05-1 ]
    ENST00000538010 ; ENSP00000445868 ; ENSG00000110987 . [Q4VC05-2 ]
    GeneIDi 605.
    KEGGi hsa:605.
    UCSCi uc001ubo.3. human. [Q4VC05-2 ]
    uc001ubp.3. human. [Q4VC05-1 ]

    Organism-specific databases

    CTDi 605.
    GeneCardsi GC12P122459.
    HGNCi HGNC:1004. BCL7A.
    HPAi HPA019762.
    MIMi 601406. gene.
    neXtProti NX_Q4VC05.
    PharmGKBi PA25314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285788.
    HOGENOMi HOG000232196.
    HOVERGENi HBG008481.
    InParanoidi Q4VC05.
    OMAi EPKVDDV.
    OrthoDBi EOG7GQXWV.
    PhylomeDBi Q4VC05.
    TreeFami TF317441.

    Miscellaneous databases

    GenomeRNAii 605.
    NextBioi 2459.
    PROi Q4VC05.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q4VC05.
    CleanExi HS_BCL7A.
    Genevestigatori Q4VC05.

    Family and domain databases

    InterProi IPR006804. BCL7.
    [Graphical view ]
    PANTHERi PTHR12767. PTHR12767. 1 hit.
    Pfami PF04714. BCL_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon."
      Zani V.J., Asou N., Jadayel D., Heward J.M., Shipley J., Nacheva E., Takasuki K., Catovsky D., Dyer M.J.S.
      Blood 87:3124-3134(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney and Thalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBCL7A_HUMAN
    AccessioniPrimary (citable) accession number: Q4VC05
    Secondary accession number(s): B4DJN6
    , B7ZB21, Q13843, Q14CT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3