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Protein

B-cell CLL/lymphoma 7 protein family member A

Gene

BCL7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member A
Gene namesi
Name:BCL7A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 12, Chromosome 7

Organism-specific databases

HGNCiHGNC:1004. BCL7A.

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.

Organism-specific databases

PharmGKBiPA25314.

Polymorphism and mutation databases

BioMutaiBCL7A.
DMDMi74754614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210B-cell CLL/lymphoma 7 protein family member APRO_0000239823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031Phosphoserine1 Publication
Modified residuei207 – 2071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ4VC05.
PaxDbiQ4VC05.
PRIDEiQ4VC05.

PTM databases

PhosphoSiteiQ4VC05.

Expressioni

Gene expression databases

BgeeiQ4VC05.
CleanExiHS_BCL7A.
GenevisibleiQ4VC05. HS.

Organism-specific databases

HPAiHPA019762.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-359917,EBI-3905054

Protein-protein interaction databases

BioGridi107077. 51 interactions.
DIPiDIP-27608N.
IntActiQ4VC05. 4 interactions.
MINTiMINT-1133208.

Structurei

3D structure databases

ProteinModelPortaliQ4VC05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiNOG285788.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ4VC05.
OMAiKLETSQQ.
OrthoDBiEOG7GQXWV.
PhylomeDBiQ4VC05.
TreeFamiTF317441.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VC05-1) [UniParc]FASTAAdd to basket

Also known as: Isoform b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP
60 70 80 90 100
VTEPKVDDKN KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA
110 120 130 140 150
DASPIKQENS SNSSPAPEPN SAVPSDGTEA KVDEAQADGK EHPGAEDASD
160 170 180 190 200
EQNSQSSMEH SMNSSEKVDR QPSGDSGLAA ETSAISQDLE GVPPSKKMKL
210
EASQQNSEEM
Length:210
Mass (Da):22,810
Last modified:July 5, 2005 - v1
Checksum:i4AB4AC3B309ADDB8
GO
Isoform 2 (identifier: Q4VC05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: Q → QVPRSRSQRGSQIGREPIGLSG

Show »
Length:231
Mass (Da):25,029
Checksum:i48B6CD8004914602
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201N → T.
Corresponds to variant rs34821485 [ dbSNP | Ensembl ].
VAR_033539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 1871Q → QVPRSRSQRGSQIGREPIGL SG in isoform 2. 2 PublicationsVSP_019271

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89984 mRNA. Translation: CAA62011.1.
AK296159 mRNA. Translation: BAG58898.1.
AK316486 mRNA. Translation: BAH14857.1.
CH471054 Genomic DNA. Translation: EAW98302.1.
BC094723 mRNA. Translation: AAH94723.1.
BC113627 mRNA. Translation: AAI13628.1.
CCDSiCCDS53841.1. [Q4VC05-1]
CCDS9226.1. [Q4VC05-2]
PIRiS58237. S58245.
RefSeqiNP_001019979.1. NM_001024808.2. [Q4VC05-1]
NP_066273.1. NM_020993.4. [Q4VC05-2]
UniGeneiHs.530970.

Genome annotation databases

EnsembliENST00000261822; ENSP00000261822; ENSG00000110987.
ENST00000538010; ENSP00000445868; ENSG00000110987. [Q4VC05-2]
ENST00000628804; ENSP00000485990; ENSG00000281529. [Q4VC05-2]
ENST00000630580; ENSP00000486981; ENSG00000281529.
GeneIDi605.
KEGGihsa:605.
UCSCiuc001ubo.3. human. [Q4VC05-2]
uc001ubp.3. human. [Q4VC05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89984 mRNA. Translation: CAA62011.1.
AK296159 mRNA. Translation: BAG58898.1.
AK316486 mRNA. Translation: BAH14857.1.
CH471054 Genomic DNA. Translation: EAW98302.1.
BC094723 mRNA. Translation: AAH94723.1.
BC113627 mRNA. Translation: AAI13628.1.
CCDSiCCDS53841.1. [Q4VC05-1]
CCDS9226.1. [Q4VC05-2]
PIRiS58237. S58245.
RefSeqiNP_001019979.1. NM_001024808.2. [Q4VC05-1]
NP_066273.1. NM_020993.4. [Q4VC05-2]
UniGeneiHs.530970.

3D structure databases

ProteinModelPortaliQ4VC05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107077. 51 interactions.
DIPiDIP-27608N.
IntActiQ4VC05. 4 interactions.
MINTiMINT-1133208.

PTM databases

PhosphoSiteiQ4VC05.

Polymorphism and mutation databases

BioMutaiBCL7A.
DMDMi74754614.

Proteomic databases

MaxQBiQ4VC05.
PaxDbiQ4VC05.
PRIDEiQ4VC05.

Protocols and materials databases

DNASUi605.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261822; ENSP00000261822; ENSG00000110987.
ENST00000538010; ENSP00000445868; ENSG00000110987. [Q4VC05-2]
ENST00000628804; ENSP00000485990; ENSG00000281529. [Q4VC05-2]
ENST00000630580; ENSP00000486981; ENSG00000281529.
GeneIDi605.
KEGGihsa:605.
UCSCiuc001ubo.3. human. [Q4VC05-2]
uc001ubp.3. human. [Q4VC05-1]

Organism-specific databases

CTDi605.
GeneCardsiGC12P122459.
HGNCiHGNC:1004. BCL7A.
HPAiHPA019762.
MIMi601406. gene.
neXtProtiNX_Q4VC05.
PharmGKBiPA25314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG285788.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ4VC05.
OMAiKLETSQQ.
OrthoDBiEOG7GQXWV.
PhylomeDBiQ4VC05.
TreeFamiTF317441.

Miscellaneous databases

ChiTaRSiBCL7A. human.
GenomeRNAii605.
NextBioi2459.
PROiQ4VC05.
SOURCEiSearch...

Gene expression databases

BgeeiQ4VC05.
CleanExiHS_BCL7A.
GenevisibleiQ4VC05. HS.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon."
    Zani V.J., Asou N., Jadayel D., Heward J.M., Shipley J., Nacheva E., Takasuki K., Catovsky D., Dyer M.J.S.
    Blood 87:3124-3134(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBCL7A_HUMAN
AccessioniPrimary (citable) accession number: Q4VC05
Secondary accession number(s): B4DJN6
, B7ZB21, Q13843, Q14CT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2005
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.