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Q4VBS4

- MAP12_DANRE

UniProt

Q4VBS4 - MAP12_DANRE

Protein

Methionine aminopeptidase 1D, mitochondrial

Gene

metap1d

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.UniRule annotation

    Catalytic activityi

    Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei164 – 1641SubstrateUniRule annotation
    Metal bindingi181 – 1811Divalent metal cation 1UniRule annotation
    Metal bindingi192 – 1921Divalent metal cation 1UniRule annotation
    Metal bindingi192 – 1921Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi255 – 2551Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi287 – 2871Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi318 – 3181Divalent metal cation 1UniRule annotation
    Metal bindingi318 – 3181Divalent metal cation 2; catalyticUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-HAMAP
    2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein initiator methionine removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding

    Protein family/group databases

    MEROPSiM24.028.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine aminopeptidase 1D, mitochondrialUniRule annotation (EC:3.4.11.18UniRule annotation)
    Short name:
    MAP 1DUniRule annotation
    Short name:
    MetAP 1DUniRule annotation
    Alternative name(s):
    Methionyl aminopeptidase type 1D, mitochondrial
    Peptidase M 1DUniRule annotation
    Gene namesi
    Name:metap1d
    Synonyms:map1d
    ORF Names:zgc:110461
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050522-71. metap1d.

    Subcellular locationi

    Mitochondrion UniRule annotation

    GO - Cellular componenti

    1. mitochondrion Source: HGNC

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4747MitochondrionUniRule annotationAdd
    BLAST
    Chaini48 – 338291Methionine aminopeptidase 1D, mitochondrialPRO_0000314128Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ4VBS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0024.
    HOGENOMiHOG000030427.
    HOVERGENiHBG067178.
    InParanoidiQ4VBS4.
    KOiK01265.
    PhylomeDBiQ4VBS4.

    Family and domain databases

    Gene3Di3.90.230.10. 1 hit.
    HAMAPiMF_01974. MetAP_1.
    InterProiIPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002467. Pept_M24A_MAP1.
    [Graphical view]
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    PRINTSiPR00599. MAPEPTIDASE.
    SUPFAMiSSF55920. SSF55920. 1 hit.
    TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.
    PROSITEiPS00680. MAP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4VBS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPCAAQCL YRTGGLRLLQ RISRLPHCHK DASLAHQCQF HRSFFWRKPK    50
    TSHSVVRPAI VRPAYPVPKH IQRPDYVSSS KVPEWPDYIE IKDEEQIQGL 100
    RRACQLARHI LLLTGNSLKV GMTTDEIDFI VHQEAIRHNG YPSPLHYGGF 150
    PKSVCTSVNN VVCHGIPDSR PLQDGDIINI DVTVYLEGYH GDTSETFLIG 200
    SVNDQGRKLV DVARQCRDQA IAACGPGQPL CVIGNIISNI ANSNGFRVCP 250
    YFIGHGIGEY FHGHPEIWHH ANDNDLKMEE GMSFTIEPIL MEGTSGFRIL 300
    SDKWTAVSVD DKRSAQFEHT VVITSDGVEI LTKLPEED 338
    Length:338
    Mass (Da):37,785
    Last modified:July 5, 2005 - v1
    Checksum:i4FB31183518AD263
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095283 mRNA. Translation: AAH95283.1.
    RefSeqiNP_001019563.1. NM_001024392.1.
    UniGeneiDr.42917.

    Genome annotation databases

    GeneIDi554090.
    KEGGidre:554090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC095283 mRNA. Translation: AAH95283.1 .
    RefSeqi NP_001019563.1. NM_001024392.1.
    UniGenei Dr.42917.

    3D structure databases

    ProteinModelPortali Q4VBS4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M24.028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 554090.
    KEGGi dre:554090.

    Organism-specific databases

    CTDi 254042.
    ZFINi ZDB-GENE-050522-71. metap1d.

    Phylogenomic databases

    eggNOGi COG0024.
    HOGENOMi HOG000030427.
    HOVERGENi HBG067178.
    InParanoidi Q4VBS4.
    KOi K01265.
    PhylomeDBi Q4VBS4.

    Miscellaneous databases

    NextBioi 20880657.
    PROi Q4VBS4.

    Family and domain databases

    Gene3Di 3.90.230.10. 1 hit.
    HAMAPi MF_01974. MetAP_1.
    InterProi IPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002467. Pept_M24A_MAP1.
    [Graphical view ]
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    PRINTSi PR00599. MAPEPTIDASE.
    SUPFAMi SSF55920. SSF55920. 1 hit.
    TIGRFAMsi TIGR00500. met_pdase_I. 1 hit.
    PROSITEi PS00680. MAP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiMAP12_DANRE
    AccessioniPrimary (citable) accession number: Q4VBS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3