Q4VBS4 (AMP1D_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionine aminopeptidase 1D, mitochondrial
EC=3.4.11.18

Alternative name(s):
Methionyl aminopeptidase type 1D, mitochondrial

Gene names

Name:	metap1d
Synonyms:	map1d
ORF Names:	zgc:110461

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Removes the amino-terminal methionine from nascent proteins By similarity.
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Cofactor	Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the peptidase M24A family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Cobalt Metal-binding
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from sequence or structural similarity. Source: HGNC
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 47	47	Mitochondrion Potential
	Chain	48 – 338	291	Methionine aminopeptidase 1D, mitochondrial		PRO_0000314128
Sites
	Metal binding	181	1	Cobalt 1 By similarity
	Metal binding	192	1	Cobalt 1 By similarity
	Metal binding	192	1	Cobalt 2 By similarity
	Metal binding	255	1	Cobalt 2 By similarity
	Metal binding	287	1	Cobalt 2 By similarity
	Metal binding	318	1	Cobalt 1 By similarity
	Metal binding	318	1	Cobalt 2 By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	262	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4VBS4 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 4FB31183518AD263	FASTA	338	37,785
	10 20 30 40 50 60 MAAPCAAQCL YRTGGLRLLQ RISRLPHCHK DASLAHQCQF HRSFFWRKPK TSHSVVRPAI 70 80 90 100 110 120 VRPAYPVPKH IQRPDYVSSS KVPEWPDYIE IKDEEQIQGL RRACQLARHI LLLTGNSLKV 130 140 150 160 170 180 GMTTDEIDFI VHQEAIRHNG YPSPLHYGGF PKSVCTSVNN VVCHGIPDSR PLQDGDIINI 190 200 210 220 230 240 DVTVYLEGYH GDTSETFLIG SVNDQGRKLV DVARQCRDQA IAACGPGQPL CVIGNIISNI 250 260 270 280 290 300 ANSNGFRVCP YFIGHGIGEY FHGHPEIWHH ANDNDLKMEE GMSFTIEPIL MEGTSGFRIL 310 320 330 SDKWTAVSVD DKRSAQFEHT VVITSDGVEI LTKLPEED

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC095283 mRNA. Translation: AAH95283.1.
IPI	IPI00510200.
RefSeq	NP_001019563.1. NM_001024392.1.
UniGene	Dr.42917.
3D structure databases
HSSP	HSSP built from PDB template 2B3H based on UniProtKB P53582.
ProteinModelPortal	Q4VBS4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4VBS4.
Protein family/group databases
MEROPS	M24.028.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	554090.
KEGG	dre:554090.
Organism-specific databases
CTD	254042.
ZFIN	ZDB-GENE-050522-71. map1d.
Phylogenomic databases
eggNOG	fiNOG08122.
GeneTree	ENSGT00390000002284.
HOGENOM	HBG299384.
HOVERGEN	HBG067178.
InParanoid	Q4VBS4.
OrthoDB	EOG4H9XKZ.
PhylomeDB	Q4VBS4.
Gene expression databases
Bgee	Q4VBS4.
Family and domain databases
InterPro	IPR001714. Pept_M24_MAP. IPR000994. Pept_M24_structural-domain. IPR002467. Pept_M24A_MAP1. [Graphical view]
Gene3D	G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KO	K01265.
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
PRINTS	PR00599. MAPEPTIDASE.
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMs	TIGR00500. Met_pdase_I. 1 hit.
PROSITE	PS00680. MAP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMP1D_DANRE

Accession

Primary (citable) accession number: Q4VBS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2005
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program