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Protein

GDNF-inducible zinc finger protein 1

Gene

Gzf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri315 – 337C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF-inducible zinc finger protein 1
Alternative name(s):
Zinc finger protein 336
Gene namesi
Name:Gzf1
Synonyms:Zfp336
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921783. Gzf1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • Golgi apparatus Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004096601 – 706GDNF-inducible zinc finger protein 1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei611PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4VBD9.
MaxQBiQ4VBD9.
PaxDbiQ4VBD9.
PeptideAtlasiQ4VBD9.
PRIDEiQ4VBD9.

PTM databases

iPTMnetiQ4VBD9.
PhosphoSitePlusiQ4VBD9.

Expressioni

Tissue specificityi

Expressed in several tissues, with highest levels in liver. Also expressed in embryos from 7 to 17 dpc.1 Publication

Developmental stagei

At 13.5-14.5 dpc, strong expression in ureteric buds (at protein level). Expression decreases in the kidney after birth (at protein level).

Gene expression databases

BgeeiENSMUSG00000027439.
ExpressionAtlasiQ4VBD9. baseline and differential.
GenevisibleiQ4VBD9. MM.

Interactioni

Subunit structurei

Interacts with NCL.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028928.

Structurei

3D structure databases

ProteinModelPortaliQ4VBD9.
SMRiQ4VBD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 103BTBPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri315 – 337C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133833.
HOGENOMiHOG000059627.
HOVERGENiHBG054256.
InParanoidiQ4VBD9.
OMAiKHISTYH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ4VBD9.
TreeFamiTF350965.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VBD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGTVLLES KSSPLNLLHE MHELRLLGHL CDVTVSIENQ GVHEDFMAHK
60 70 80 90 100
AVLAATSKFF KEVFLNEKSA DGTRTNVYLN EVQAVDFASF LEFVYTAKVR
110 120 130 140 150
VEEDRVQQML EVAEKLKCLD LSETCLQLKK QMLESVLLEL QNFSESQEVE
160 170 180 190 200
ASSGPQVSVT PSSKASVPGE DAHSNGLVDS SDYPIERLGN GLSPETPSKK
210 220 230 240 250
CKEKLDKKKD VAKPPFPKIR RASGRLAGKK VFVEIPKKKY TRRLREQQKS
260 270 280 290 300
AEEAAENDKC PQDQSPDNER METEPAAKSE ACPASVELEE SLQKVEGEKE
310 320 330 340 350
EEEGKDGEEK KKSNFQCTVC DKAFLYEKSF LKHIKYHHGV ATEVVYRCDT
360 370 380 390 400
CGQTFANRCN LKSHQRHVHS SERHFPCEMC AKKFKRKKDV KRHVLQVHEG
410 420 430 440 450
GGERHRCGQC GKGLSSKTAL RLHERTHTGD KPYGCTKCDA KFSQPSALKT
460 470 480 490 500
HLRVHTGERP FVCDECGARF TQNHMLIYHK RCHTGERPFM CETCGKSFAS
510 520 530 540 550
KEYLKHHNRI HTGSKPFKCE VCLRTFAQRN SLYQHIKVHT GERPYCCDQC
560 570 580 590 600
GKQFTQVNAL QRHHRIHTGE KPYMCNACGR TFTDKSTLRR HTSIHDKNTP
610 620 630 640 650
WKSFLVIVDG SPKNDEGHKT EQPDDEYASP KLSDRLLSFG ENSHFNNLLE
660 670 680 690 700
VQGNVPAVQE NSSTGAACKA VVSQDALLTT SISALGELTP QAVSMPAHLP

SLTNME
Length:706
Mass (Da):79,533
Last modified:June 28, 2011 - v2
Checksum:i63E082642FC0956C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187R → T in AAH96015 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100266 mRNA. Translation: BAC98465.1.
AK052820 mRNA. Translation: BAC35160.1.
AK053262 mRNA. Translation: BAC35327.1.
AK141153 mRNA. Translation: BAE24571.1.
AL928638 Genomic DNA. Translation: CAM22533.1.
CH466519 Genomic DNA. Translation: EDL28537.1.
CH466519 Genomic DNA. Translation: EDL28538.1.
BC096015 mRNA. Translation: AAH96015.1.
CCDSiCCDS16841.1.
RefSeqiNP_083262.1. NM_028986.3.
XP_006500367.1. XM_006500304.3.
XP_006500368.1. XM_006500305.3.
UniGeneiMm.136913.

Genome annotation databases

EnsembliENSMUST00000028928; ENSMUSP00000028928; ENSMUSG00000027439.
GeneIDi74533.
KEGGimmu:74533.
UCSCiuc008mtg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100266 mRNA. Translation: BAC98465.1.
AK052820 mRNA. Translation: BAC35160.1.
AK053262 mRNA. Translation: BAC35327.1.
AK141153 mRNA. Translation: BAE24571.1.
AL928638 Genomic DNA. Translation: CAM22533.1.
CH466519 Genomic DNA. Translation: EDL28537.1.
CH466519 Genomic DNA. Translation: EDL28538.1.
BC096015 mRNA. Translation: AAH96015.1.
CCDSiCCDS16841.1.
RefSeqiNP_083262.1. NM_028986.3.
XP_006500367.1. XM_006500304.3.
XP_006500368.1. XM_006500305.3.
UniGeneiMm.136913.

3D structure databases

ProteinModelPortaliQ4VBD9.
SMRiQ4VBD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028928.

PTM databases

iPTMnetiQ4VBD9.
PhosphoSitePlusiQ4VBD9.

Proteomic databases

EPDiQ4VBD9.
MaxQBiQ4VBD9.
PaxDbiQ4VBD9.
PeptideAtlasiQ4VBD9.
PRIDEiQ4VBD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028928; ENSMUSP00000028928; ENSMUSG00000027439.
GeneIDi74533.
KEGGimmu:74533.
UCSCiuc008mtg.2. mouse.

Organism-specific databases

CTDi64412.
MGIiMGI:1921783. Gzf1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133833.
HOGENOMiHOG000059627.
HOVERGENiHBG054256.
InParanoidiQ4VBD9.
OMAiKHISTYH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ4VBD9.
TreeFamiTF350965.

Miscellaneous databases

ChiTaRSiGzf1. mouse.
PROiQ4VBD9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027439.
ExpressionAtlasiQ4VBD9. baseline and differential.
GenevisibleiQ4VBD9. MM.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGZF1_MOUSE
AccessioniPrimary (citable) accession number: Q4VBD9
Secondary accession number(s): Q8BGY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.