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Protein

GDNF-inducible zinc finger protein 1

Gene

Gzf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri315 – 337C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF-inducible zinc finger protein 1
Alternative name(s):
Zinc finger protein 336
Gene namesi
Name:Gzf1Imported
Synonyms:Zfp336
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921783 Gzf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004096601 – 706GDNF-inducible zinc finger protein 1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei611PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ4VBD9
MaxQBiQ4VBD9
PaxDbiQ4VBD9
PeptideAtlasiQ4VBD9
PRIDEiQ4VBD9

PTM databases

iPTMnetiQ4VBD9
PhosphoSitePlusiQ4VBD9

Expressioni

Tissue specificityi

Expressed in several tissues, with highest levels in liver. Also expressed in embryos from 7 to 17 dpc.1 Publication

Developmental stagei

At 13.5-14.5 dpc, strong expression in ureteric buds (at protein level). Expression decreases in the kidney after birth (at protein level). Expressed in the eyes and limbs during development (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000027439
ExpressionAtlasiQ4VBD9 baseline and differential
GenevisibleiQ4VBD9 MM

Interactioni

Subunit structurei

Interacts with NCL.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028928

Structurei

3D structure databases

ProteinModelPortaliQ4VBD9
SMRiQ4VBD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 103BTBPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri315 – 337C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 567C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri573 – 595C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136554
HOGENOMiHOG000059627
HOVERGENiHBG054256
InParanoidiQ4VBD9
KOiK22402
OMAiKYTRRLR
OrthoDBiEOG091G02KC
PhylomeDBiQ4VBD9
TreeFamiTF350965

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q4VBD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGTVLLES KSSPLNLLHE MHELRLLGHL CDVTVSIENQ GVHEDFMAHK
60 70 80 90 100
AVLAATSKFF KEVFLNEKSA DGTRTNVYLN EVQAVDFASF LEFVYTAKVR
110 120 130 140 150
VEEDRVQQML EVAEKLKCLD LSETCLQLKK QMLESVLLEL QNFSESQEVE
160 170 180 190 200
ASSGPQVSVT PSSKASVPGE DAHSNGLVDS SDYPIERLGN GLSPETPSKK
210 220 230 240 250
CKEKLDKKKD VAKPPFPKIR RASGRLAGKK VFVEIPKKKY TRRLREQQKS
260 270 280 290 300
AEEAAENDKC PQDQSPDNER METEPAAKSE ACPASVELEE SLQKVEGEKE
310 320 330 340 350
EEEGKDGEEK KKSNFQCTVC DKAFLYEKSF LKHIKYHHGV ATEVVYRCDT
360 370 380 390 400
CGQTFANRCN LKSHQRHVHS SERHFPCEMC AKKFKRKKDV KRHVLQVHEG
410 420 430 440 450
GGERHRCGQC GKGLSSKTAL RLHERTHTGD KPYGCTKCDA KFSQPSALKT
460 470 480 490 500
HLRVHTGERP FVCDECGARF TQNHMLIYHK RCHTGERPFM CETCGKSFAS
510 520 530 540 550
KEYLKHHNRI HTGSKPFKCE VCLRTFAQRN SLYQHIKVHT GERPYCCDQC
560 570 580 590 600
GKQFTQVNAL QRHHRIHTGE KPYMCNACGR TFTDKSTLRR HTSIHDKNTP
610 620 630 640 650
WKSFLVIVDG SPKNDEGHKT EQPDDEYASP KLSDRLLSFG ENSHFNNLLE
660 670 680 690 700
VQGNVPAVQE NSSTGAACKA VVSQDALLTT SISALGELTP QAVSMPAHLP

SLTNME
Length:706
Mass (Da):79,533
Last modified:June 28, 2011 - v2
Checksum:i63E082642FC0956C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187R → T in AAH96015 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100266 mRNA Translation: BAC98465.1
AK052820 mRNA Translation: BAC35160.1
AK053262 mRNA Translation: BAC35327.1
AK141153 mRNA Translation: BAE24571.1
AL928638 Genomic DNA Translation: CAM22533.1
CH466519 Genomic DNA Translation: EDL28537.1
CH466519 Genomic DNA Translation: EDL28538.1
BC096015 mRNA Translation: AAH96015.1
CCDSiCCDS16841.1
RefSeqiNP_083262.1, NM_028986.3
XP_006500367.1, XM_006500304.3
XP_006500368.1, XM_006500305.3
UniGeneiMm.136913

Genome annotation databases

EnsembliENSMUST00000028928; ENSMUSP00000028928; ENSMUSG00000027439
GeneIDi74533
KEGGimmu:74533
UCSCiuc008mtg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGZF1_MOUSE
AccessioniPrimary (citable) accession number: Q4VBD9
Secondary accession number(s): Q8BGY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health