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Protein

Transmembrane anterior posterior transformation protein 1

Gene

Tapt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a downstream effector of Hoxc8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development.1 Publication

GO - Biological processi

  • embryonic skeletal system development Source: MGI
  • in utero embryonic development Source: MGI
  • post-embryonic development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane anterior posterior transformation protein 1
Gene namesi
Name:Tapt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2683537. Tapt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei154 – 17623HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice die during perinatal development and are the cause of the L5Jcs1 phenotype. They exhibit posterior-to-anterior transformations of the vertebral column midsection, similar to mice deficient for Hoxc8 and Hoxc9.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 564563Transmembrane anterior posterior transformation protein 1PRO_0000328873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei520 – 5201PhosphoserineCombined sources
Modified residuei526 – 5261PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ4VBD2.
MaxQBiQ4VBD2.
PaxDbiQ4VBD2.
PRIDEiQ4VBD2.

PTM databases

PhosphoSiteiQ4VBD2.
SwissPalmiQ4VBD2.

Expressioni

Tissue specificityi

Ubiquitous. Expressed throughout embryo.1 Publication

Gene expression databases

BgeeiQ4VBD2.
ExpressionAtlasiQ4VBD2. baseline and differential.
GenevisibleiQ4VBD2. MM.

Interactioni

Protein-protein interaction databases

BioGridi231097. 9 interactions.
IntActiQ4VBD2. 9 interactions.
STRINGi10090.ENSMUSP00000062110.

Structurei

3D structure databases

ProteinModelPortaliQ4VBD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 3828Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the TAPT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2490. Eukaryota.
ENOG410XT6F. LUCA.
GeneTreeiENSGT00390000010628.
HOGENOMiHOG000154508.
HOVERGENiHBG108546.
InParanoidiQ4VBD2.
OMAiTCTPGKP.
OrthoDBiEOG7KWSH3.
PhylomeDBiQ4VBD2.
TreeFamiTF105962.

Family and domain databases

InterProiIPR008010. Tatp1.
[Graphical view]
PANTHERiPTHR13317. PTHR13317. 1 hit.
PfamiPF05346. DUF747. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VBD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVCDAAAP GEGGGGGADG PERTGRGEAE QPGGGGHGPA PQHTETLGFY
60 70 80 90 100
ESDRRREKRR GRAELSLLRF LSAELTRGYF LEHNEAKYTE RRERVYTCMR
110 120 130 140 150
IPRELEKLMF FGIFLCLDAF LYVFTLLPLR VFLALFRLLT LPCYGLRDRR
160 170 180 190 200
LLQPAQVCDI LKGVILVICY FMMHYVDYSM MYHLIRGQSV IKLYIIYNML
210 220 230 240 250
EVADRLFSSF GQDILDALYW TATEPKERKR AHIGVIPHFF MAVLYVFLHA
260 270 280 290 300
ILIMVQATTL NVAFNSHNKS LLTIMMSNNF VEIKGSVFKK FEKNNLFQMS
310 320 330 340 350
NSDIKERFTN YVLLLIVCLR NMEQFSWNPD HLWVLFPDVC MVIASEIAVD
360 370 380 390 400
IVKHAFITKF NDITADVYSE YRASLAFDLV SSRQKNAYTD YSDSVARRMG
410 420 430 440 450
FIPLPLAVLL IRVVTSSIKV QGILSYACVI LFYFGLISLK ILNSIVLLGK
460 470 480 490 500
SCQYVKEAKM EEKLFNPPPA STPGKPSSKS QSKGKPSQGL STEENLSASV
510 520 530 540 550
TSQPGHQKEN VIPLLVTSNS DQFLTTPDGD EKDITQENSE LKHRSSKKDL
560
LEIDRFTICG NRID
Length:564
Mass (Da):63,894
Last modified:April 8, 2008 - v2
Checksum:i97D28BC7970C61C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103621 Genomic DNA. No translation available.
BC096038 mRNA. Translation: AAH96038.1.
AK030002 mRNA. Translation: BAC26728.1.
CCDSiCCDS19270.1.
RefSeqiNP_776125.2. NM_173764.3.
UniGeneiMm.30688.
Mm.369319.

Genome annotation databases

EnsembliENSMUST00000055128; ENSMUSP00000062110; ENSMUSG00000046985.
GeneIDi231225.
KEGGimmu:231225.
UCSCiuc008xin.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103621 Genomic DNA. No translation available.
BC096038 mRNA. Translation: AAH96038.1.
AK030002 mRNA. Translation: BAC26728.1.
CCDSiCCDS19270.1.
RefSeqiNP_776125.2. NM_173764.3.
UniGeneiMm.30688.
Mm.369319.

3D structure databases

ProteinModelPortaliQ4VBD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231097. 9 interactions.
IntActiQ4VBD2. 9 interactions.
STRINGi10090.ENSMUSP00000062110.

PTM databases

PhosphoSiteiQ4VBD2.
SwissPalmiQ4VBD2.

Proteomic databases

EPDiQ4VBD2.
MaxQBiQ4VBD2.
PaxDbiQ4VBD2.
PRIDEiQ4VBD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055128; ENSMUSP00000062110; ENSMUSG00000046985.
GeneIDi231225.
KEGGimmu:231225.
UCSCiuc008xin.1. mouse.

Organism-specific databases

CTDi202018.
MGIiMGI:2683537. Tapt1.

Phylogenomic databases

eggNOGiKOG2490. Eukaryota.
ENOG410XT6F. LUCA.
GeneTreeiENSGT00390000010628.
HOGENOMiHOG000154508.
HOVERGENiHBG108546.
InParanoidiQ4VBD2.
OMAiTCTPGKP.
OrthoDBiEOG7KWSH3.
PhylomeDBiQ4VBD2.
TreeFamiTF105962.

Miscellaneous databases

NextBioi380461.
PROiQ4VBD2.
SOURCEiSearch...

Gene expression databases

BgeeiQ4VBD2.
ExpressionAtlasiQ4VBD2. baseline and differential.
GenevisibleiQ4VBD2. MM.

Family and domain databases

InterProiIPR008010. Tatp1.
[Graphical view]
PANTHERiPTHR13317. PTHR13317. 1 hit.
PfamiPF05346. DUF747. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-564.
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-564.
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations."
    Howell G.R., Shindo M., Murray S., Gridley T., Wilson L.A., Schimenti J.C.
    Genetics 175:699-707(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND THR-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTAPT1_MOUSE
AccessioniPrimary (citable) accession number: Q4VBD2
Secondary accession number(s): Q8CDI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 13, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.