ID   Q4VAQ0_HUMAN            Unreviewed;       427 AA.
AC   Q4VAQ0;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   SubName: Full=COL8A2 protein {ECO:0000313|EMBL:AAH96296.1};
GN   Name=COL8A2 {ECO:0000313|EMBL:AAH96296.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH96296.1};
RN   [1] {ECO:0000313|EMBL:AAH96296.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q4VAQ0; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10241815, EBI-11343438;
CC       Q4VAQ0; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-10241815, EBI-12935759;
CC       Q4VAQ0; Q8WZ55: BSND; NbExp=3; IntAct=EBI-10241815, EBI-7996695;
CC       Q4VAQ0; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-10241815, EBI-6942903;
CC       Q4VAQ0; P00387: CYB5R3; NbExp=3; IntAct=EBI-10241815, EBI-1046040;
CC       Q4VAQ0; Q6PI48: DARS2; NbExp=3; IntAct=EBI-10241815, EBI-3917045;
CC       Q4VAQ0; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10241815, EBI-18304435;
CC       Q4VAQ0; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10241815, EBI-12142257;
CC       Q4VAQ0; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10241815, EBI-13345167;
CC       Q4VAQ0; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10241815, EBI-11721746;
CC       Q4VAQ0; P15941-11: MUC1; NbExp=3; IntAct=EBI-10241815, EBI-17263240;
CC       Q4VAQ0; O00623: PEX12; NbExp=3; IntAct=EBI-10241815, EBI-594836;
CC       Q4VAQ0; Q53GL0: PLEKHO1; NbExp=3; IntAct=EBI-10241815, EBI-949945;
CC       Q4VAQ0; O43765: SGTA; NbExp=3; IntAct=EBI-10241815, EBI-347996;
CC       Q4VAQ0; Q00059: TFAM; NbExp=3; IntAct=EBI-10241815, EBI-1049924;
CC       Q4VAQ0; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10241815, EBI-6447886;
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DR   EMBL; BC096296; AAH96296.1; -; mRNA.
DR   AlphaFoldDB; Q4VAQ0; -.
DR   IntAct; Q4VAQ0; 29.
DR   PeptideAtlas; Q4VAQ0; -.
DR   ProteomicsDB; 62289; -.
DR   UCSC; uc057eto.1; human.
DR   HOGENOM; CLU_780661_0_0_1; -.
DR   ChiTaRS; COL8A2; human.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427:SF49; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   1: Evidence at protein level;
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..427
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030175694"
FT   DOMAIN          294..427
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
FT   REGION          70..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..100
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..234
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  42481 MW;  978F23F2F95C6C74 CRC64;
     MLGTLTPLSS LLLLLLVLVL GCGPRASSGG GAGGAAGYAP VKYIQPMQKG PVGPPFREGK
     GQYLEMPLPL LPMDLKGEPG PPGKPGPRGP PGPPGFPGKP GMGKPGLHGQ PGPAGPPGFS
     RMGKAGPPGL PGKVGPPGQP GLRGEPGIRG DQGLRGPPGP PGLPGPSGIT IPGKPGAQGV
     PGPPGFQGEP GPQGEPGPPG DRGLKGDNGV GQPGLPGAPG QGGAPGPPGL PGPAGLGKPG
     LDGLPGAPGD KGESGPPGAF DETGIAGLHL PNGGVEGAVL GKGGKPQFGL GELSAHATPA
     FTAVLTSPFP ASGMPVKFDR TLYNGHSGYN PATGIFTCPV GGVYYFAYHV HVKGTNVWVA
     LYKNNVPATY TYDEYKKGYL DQASGGAVLQ LRPNDQVWVQ MPSDQANGLY STEYIHSSFS
     GFLLCPT
//