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Protein
Submitted name:

Ras family member A

Gene

Rhoa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GTPase activity Source: MGI
  3. GTP binding Source: UniProtKB-KW
  4. myosin binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. androgen receptor signaling pathway Source: MGI
  3. apical junction assembly Source: MGI
  4. apolipoprotein A-I-mediated signaling pathway Source: MGI
  5. cell adhesion Source: MGI
  6. cell differentiation Source: MGI
  7. cell-matrix adhesion Source: MGI
  8. cell morphogenesis Source: MGI
  9. cerebral cortex cell migration Source: MGI
  10. cleavage furrow formation Source: MGI
  11. cytoskeleton organization Source: MGI
  12. forebrain radial glial cell differentiation Source: MGI
  13. integrin-mediated signaling pathway Source: MGI
  14. metabolic process Source: GOC
  15. negative chemotaxis Source: MGI
  16. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  17. negative regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
  18. negative regulation of neuron apoptotic process Source: MGI
  19. negative regulation of neuron differentiation Source: Ensembl
  20. neuron projection morphogenesis Source: Ensembl
  21. positive regulation of actin filament polymerization Source: Ensembl
  22. positive regulation of cell adhesion Source: Ensembl
  23. positive regulation of cell growth Source: Ensembl
  24. positive regulation of cell migration Source: Ensembl
  25. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  26. positive regulation of cytokinesis Source: MGI
  27. positive regulation of neuron apoptotic process Source: Ensembl
  28. positive regulation of neuron differentiation Source: MGI
  29. positive regulation of podosome assembly Source: MGI
  30. positive regulation of smooth muscle contraction Source: Ensembl
  31. positive regulation of stress fiber assembly Source: MGI
  32. positive regulation of translation Source: Ensembl
  33. positive regulation of vasoconstriction Source: Ensembl
  34. regulation of calcium ion transport Source: Ensembl
  35. regulation of cell migration Source: MGI
  36. regulation of dendrite development Source: Ensembl
  37. regulation of neural precursor cell proliferation Source: MGI
  38. regulation of neuron projection development Source: MGI
  39. regulation of transcription from RNA polymerase II promoter Source: MGI
  40. response to amino acid Source: Ensembl
  41. response to drug Source: Ensembl
  42. response to ethanol Source: Ensembl
  43. response to glucocorticoid Source: Ensembl
  44. response to glucose Source: Ensembl
  45. response to hypoxia Source: Ensembl
  46. response to mechanical stimulus Source: Ensembl
  47. Rho protein signal transduction Source: MGI
  48. skeletal muscle satellite cell migration Source: AgBase
  49. skeletal muscle tissue development Source: MGI
  50. spindle assembly involved in mitosis Source: MGI
  51. stress-activated protein kinase signaling cascade Source: Ensembl
  52. stress fiber assembly Source: MGI
  53. wound healing, spreading of cells Source: AgBase
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ras family member AImported
Submitted name:
Ras homolog gene family, member AImported
Submitted name:
Ras homolog gene family, member A, isoform CRA_aImported
Gene namesi
Name:RhoaImported
ORF Names:mCG_13026Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096342. Rhoa.

Subcellular locationi

GO - Cellular componenti

  1. apical junction complex Source: MGI
  2. axon Source: Ensembl
  3. cell cortex Source: MGI
  4. cytosol Source: MGI
  5. extracellular vesicular exosome Source: MGI
  6. focal adhesion Source: MGI
  7. lamellipodium Source: MGI
  8. mitochondrion Source: MGI
  9. nucleus Source: MGI
  10. plasma membrane Source: MGI
  11. ruffle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ4VAE6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007959.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG009351.
KOiK04513.
OMAiRNDPHTI.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VAE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR
160 170 180 190
IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRGKKKSGC LIL
Length:193
Mass (Da):21,782
Last modified:July 5, 2005 - v1
Checksum:iC4C8BDC31FF858BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096423 mRNA. Translation: AAH96423.1.
JN971019 mRNA. Translation: AFR23588.1.
AK150475 mRNA. Translation: BAE29592.1.
AK152629 mRNA. Translation: BAE31372.1.
AK172051 mRNA. Translation: BAE42800.1.
CH466560 Genomic DNA. Translation: EDL21278.1.
CH466560 Genomic DNA. Translation: EDL21279.1.
RefSeqiNP_058082.2. NM_016802.4.
XP_006511696.1. XM_006511633.1.
UniGeneiMm.318359.
Mm.757.

Genome annotation databases

GeneIDi11848.
KEGGimmu:11848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096423 mRNA. Translation: AAH96423.1.
JN971019 mRNA. Translation: AFR23588.1.
AK150475 mRNA. Translation: BAE29592.1.
AK152629 mRNA. Translation: BAE31372.1.
AK172051 mRNA. Translation: BAE42800.1.
CH466560 Genomic DNA. Translation: EDL21278.1.
CH466560 Genomic DNA. Translation: EDL21279.1.
RefSeqiNP_058082.2. NM_016802.4.
XP_006511696.1. XM_006511633.1.
UniGeneiMm.318359.
Mm.757.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11848.
KEGGimmu:11848.

Organism-specific databases

CTDi387.
MGIiMGI:1096342. Rhoa.

Phylogenomic databases

HOVERGENiHBG009351.
KOiK04513.
OMAiRNDPHTI.

Miscellaneous databases

ChiTaRSiRhoa. mouse.
NextBioi279815.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ4VAE6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Bone marrowImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. "Pcdh clusters regulate dendritic complexity through CAKs and Rho GTPases."
    Suo L., Lu H., Wu Q.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiQ4VAE6_MOUSE
AccessioniPrimary (citable) accession number: Q4VAE6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.