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Q4VAE6

- Q4VAE6_MOUSE

UniProt

Q4VAE6 - Q4VAE6_MOUSE

Protein
Submitted name:

Ras family member A

Gene

Rhoa

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GDP binding Source: Ensembl
    2. GTPase activity Source: MGI
    3. GTP binding Source: UniProtKB-KW
    4. protein binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. androgen receptor signaling pathway Source: MGI
    3. cell adhesion Source: MGI
    4. cell differentiation Source: MGI
    5. cell-matrix adhesion Source: MGI
    6. cell morphogenesis Source: MGI
    7. cerebral cortex cell migration Source: MGI
    8. cytoskeleton organization Source: MGI
    9. forebrain radial glial cell differentiation Source: MGI
    10. integrin-mediated signaling pathway Source: MGI
    11. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    12. negative regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
    13. negative regulation of neuron apoptotic process Source: MGI
    14. negative regulation of neuron differentiation Source: Ensembl
    15. neuron projection morphogenesis Source: Ensembl
    16. positive regulation of actin filament polymerization Source: Ensembl
    17. positive regulation of cell adhesion Source: Ensembl
    18. positive regulation of cell growth Source: Ensembl
    19. positive regulation of cell migration Source: Ensembl
    20. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    21. positive regulation of neuron apoptotic process Source: Ensembl
    22. positive regulation of neuron differentiation Source: MGI
    23. positive regulation of podosome assembly Source: MGI
    24. positive regulation of smooth muscle contraction Source: Ensembl
    25. positive regulation of stress fiber assembly Source: MGI
    26. positive regulation of translation Source: Ensembl
    27. positive regulation of vasoconstriction Source: Ensembl
    28. regulation of calcium ion transport Source: Ensembl
    29. regulation of dendrite development Source: Ensembl
    30. regulation of neural precursor cell proliferation Source: MGI
    31. regulation of transcription from RNA polymerase II promoter Source: MGI
    32. response to amino acid Source: Ensembl
    33. response to drug Source: Ensembl
    34. response to ethanol Source: Ensembl
    35. response to glucocorticoid Source: Ensembl
    36. response to glucose Source: Ensembl
    37. response to hypoxia Source: Ensembl
    38. response to mechanical stimulus Source: Ensembl
    39. Rho protein signal transduction Source: MGI
    40. skeletal muscle tissue development Source: MGI
    41. stress-activated protein kinase signaling cascade Source: Ensembl
    42. stress fiber assembly Source: MGI

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ras family member AImported
    Submitted name:
    Ras homolog gene family, member AImported
    Submitted name:
    Ras homolog gene family, member A, isoform CRA_aImported
    Gene namesi
    Name:RhoaImported
    ORF Names:mCG_13026Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1096342. Rhoa.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: MGI
    3. lamellipodium Source: MGI
    4. mitochondrion Source: MGI
    5. nucleus Source: MGI
    6. plasma membrane Source: MGI
    7. ruffle membrane Source: MGI

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ4VAE6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000007959.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG009351.
    InParanoidiQ4VAE6.
    KOiK04513.
    OMAiRNDPHTI.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4VAE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG    50
    KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT 100
    PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR 150
    IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRGKKKSGC LIL 193
    Length:193
    Mass (Da):21,782
    Last modified:July 5, 2005 - v1
    Checksum:iC4C8BDC31FF858BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC096423 mRNA. Translation: AAH96423.1.
    JN971019 mRNA. Translation: AFR23588.1.
    AK150475 mRNA. Translation: BAE29592.1.
    AK152629 mRNA. Translation: BAE31372.1.
    AK172051 mRNA. Translation: BAE42800.1.
    CH466560 Genomic DNA. Translation: EDL21278.1.
    CH466560 Genomic DNA. Translation: EDL21279.1.
    RefSeqiNP_058082.2. NM_016802.4.
    XP_006511696.1. XM_006511633.1.
    UniGeneiMm.318359.
    Mm.757.

    Genome annotation databases

    GeneIDi11848.
    KEGGimmu:11848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC096423 mRNA. Translation: AAH96423.1 .
    JN971019 mRNA. Translation: AFR23588.1 .
    AK150475 mRNA. Translation: BAE29592.1 .
    AK152629 mRNA. Translation: BAE31372.1 .
    AK172051 mRNA. Translation: BAE42800.1 .
    CH466560 Genomic DNA. Translation: EDL21278.1 .
    CH466560 Genomic DNA. Translation: EDL21279.1 .
    RefSeqi NP_058082.2. NM_016802.4.
    XP_006511696.1. XM_006511633.1.
    UniGenei Mm.318359.
    Mm.757.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000007959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11848.
    KEGGi mmu:11848.

    Organism-specific databases

    CTDi 387.
    MGIi MGI:1096342. Rhoa.

    Phylogenomic databases

    HOVERGENi HBG009351.
    InParanoidi Q4VAE6.
    KOi K04513.
    OMAi RNDPHTI.

    Miscellaneous databases

    ChiTaRSi RHOA. mouse.
    NextBioi 279815.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4VAE6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary tumor metastatized to lung. Tumor arose spontaneouslyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Bone marrowImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    13. "Pcdh clusters regulate dendritic complexity through CAKs and Rho GTPases."
      Suo L., Lu H., Wu Q.
      Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.

    Entry informationi

    Entry nameiQ4VAE6_MOUSE
    AccessioniPrimary (citable) accession number: Q4VAE6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)