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Protein

Protein kinase C

Gene

Prkca

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei368ATPUniRule annotation1
Active sitei463Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi345 – 353ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-111933. Calmodulin induced events.
R-MMU-114516. Disinhibition of SNARE formation.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-1433559. Regulation of KIT signaling.
R-MMU-2179392. EGFR Transactivation by Gastrin.
R-MMU-3000170. Syndecan interactions.
R-MMU-399997. Acetylcholine regulates insulin secretion.
R-MMU-416993. Trafficking of GluR2-containing AMPA receptors.
R-MMU-4419969. Depolymerisation of the Nuclear Lamina.
R-MMU-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-MMU-5099900. WNT5A-dependent internalization of FZD4.
R-MMU-5218921. VEGFR2 mediated cell proliferation.
R-MMU-76005. Response to elevated platelet cytosolic Ca2+.
R-MMU-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
Gene namesi
Name:PrkcaImported
ORF Names:mCG_140727Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97595. Prkca.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000050965.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062392.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 86Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini101 – 151Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini172 – 260C2InterPro annotationAdd BLAST89
Domaini339 – 597Protein kinaseInterPro annotationAdd BLAST259
Domaini598 – 668AGC-kinase C-terminalInterPro annotationAdd BLAST71

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation
Contains 1 C2 domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.
HOVERGENiHBG108317.
KOiK02677.
OMAiQSKKDMI.
OrthoDBiEOG091G0QRS.
TreeFamiTF351133.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VA93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC
60 70 80 90 100
SHCTDFIWGF GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS
110 120 130 140 150
KHKFKIHTYG SPTFCDHCGS LLYGLIHQGM KCDTCDMNVH KQCVINVPSL
160 170 180 190 200
CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA KNLIPMDPNG LSDPYVKLKL
210 220 230 240 250
IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL SVEIWDWDRT
260 270 280 290 300
TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME
310 320 330 340 350
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF
360 370 380 390 400
GKVMLADRKG TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL
410 420 430 440 450
TQLHSCFQTV DRLYFVMEYV NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG
460 470 480 490 500
LFFLHKRGII YRDLKLDNVM LDSEGHIKIA DFGMCKEHMM DGVTTRTFCG
510 520 530 540 550
TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG EDEDELFQSI
560 570 580 590 600
MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI
610 620 630 640 650
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ
660 670
SDFEGFSYVN PQFVHPILQS AV
Length:672
Mass (Da):76,824
Last modified:July 5, 2005 - v1
Checksum:i948E297ADEC39012
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607041 Genomic DNA. No translation available.
AL645535 Genomic DNA. No translation available.
AL645963 Genomic DNA. No translation available.
BC096493 mRNA. Translation: AAH96493.1.
AK147084 mRNA. Translation: BAE27664.1.
CH466558 Genomic DNA. Translation: EDL34340.1.
RefSeqiNP_035231.2. NM_011101.3.
UniGeneiMm.222178.

Genome annotation databases

EnsembliENSMUST00000059595; ENSMUSP00000062392; ENSMUSG00000050965.
GeneIDi18750.
KEGGimmu:18750.
UCSCiuc011ygr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607041 Genomic DNA. No translation available.
AL645535 Genomic DNA. No translation available.
AL645963 Genomic DNA. No translation available.
BC096493 mRNA. Translation: AAH96493.1.
AK147084 mRNA. Translation: BAE27664.1.
CH466558 Genomic DNA. Translation: EDL34340.1.
RefSeqiNP_035231.2. NM_011101.3.
UniGeneiMm.222178.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059595; ENSMUSP00000062392; ENSMUSG00000050965.
GeneIDi18750.
KEGGimmu:18750.
UCSCiuc011ygr.1. mouse.

Organism-specific databases

CTDi5578.
MGIiMGI:97595. Prkca.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.
HOVERGENiHBG108317.
KOiK02677.
OMAiQSKKDMI.
OrthoDBiEOG091G0QRS.
TreeFamiTF351133.

Enzyme and pathway databases

ReactomeiR-MMU-111933. Calmodulin induced events.
R-MMU-114516. Disinhibition of SNARE formation.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-1433559. Regulation of KIT signaling.
R-MMU-2179392. EGFR Transactivation by Gastrin.
R-MMU-3000170. Syndecan interactions.
R-MMU-399997. Acetylcholine regulates insulin secretion.
R-MMU-416993. Trafficking of GluR2-containing AMPA receptors.
R-MMU-4419969. Depolymerisation of the Nuclear Lamina.
R-MMU-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-MMU-5099900. WNT5A-dependent internalization of FZD4.
R-MMU-5218921. VEGFR2 mediated cell proliferation.
R-MMU-76005. Response to elevated platelet cytosolic Ca2+.
R-MMU-8853659. RET signaling.

Miscellaneous databases

ChiTaRSiPrkca. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050965.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4VA93_MOUSE
AccessioniPrimary (citable) accession number: Q4VA93
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.