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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

slc25a26

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-DRE-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:slc25a26
Synonyms:samc
ORF Names:zgc:110080
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-050913-126. slc25a26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267S-adenosylmethionine mitochondrial carrier proteinPRO_0000317589Add
BLAST

Proteomic databases

PaxDbiQ4V9P0.

Expressioni

Gene expression databases

BgeeiENSDARG00000058208.
ExpressionAtlasiQ4V9P0. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075478.

Structurei

3D structure databases

ProteinModelPortaliQ4V9P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 7774Solcar 1Add
BLAST
Repeati86 – 16883Solcar 2Add
BLAST
Repeati177 – 26589Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ4V9P0.
KOiK15111.
OMAiFAXAGSS.
OrthoDBiEOG091G0G6Z.
PhylomeDBiQ4V9P0.
TreeFamiTF313186.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V9P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRREFTASL VAGGCAGMCV DLTLFPLDTI KTRLQSQQGF YKAGGFRGIY
60 70 80 90 100
AGVPSAAIGS FPNAAAFFVT YESTKSVFSG YTTTNLAPIT HMLAASLGEI
110 120 130 140 150
VACLIRVPTE VVKQRTQANP SISTYRVLLN SLQEEGFRGL YRGYGSTVLR
160 170 180 190 200
EIPFSLVQFP LWEYLKAVWW RRQGGRLDSW QAAVCGALAG GVAAFVTTPL
210 220 230 240 250
DVAKTWIMLA KAGTSTASGN IPMVLCEVWR SRGIPGLFAG SIPRVMFISM
260
GGFIFLGAYE KVRRTLL
Length:267
Mass (Da):28,995
Last modified:July 5, 2005 - v1
Checksum:iB7DF20E0D64E0813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096793 mRNA. Translation: AAH96793.1.
BC153538 mRNA. Translation: AAI53539.1.
RefSeqiNP_001025314.1. NM_001030143.1.
UniGeneiDr.80000.

Genome annotation databases

EnsembliENSDART00000081035; ENSDARP00000075478; ENSDARG00000058208.
GeneIDi560478.
KEGGidre:560478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096793 mRNA. Translation: AAH96793.1.
BC153538 mRNA. Translation: AAI53539.1.
RefSeqiNP_001025314.1. NM_001030143.1.
UniGeneiDr.80000.

3D structure databases

ProteinModelPortaliQ4V9P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075478.

Proteomic databases

PaxDbiQ4V9P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000081035; ENSDARP00000075478; ENSDARG00000058208.
GeneIDi560478.
KEGGidre:560478.

Organism-specific databases

CTDi115286.
ZFINiZDB-GENE-050913-126. slc25a26.

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ4V9P0.
KOiK15111.
OMAiFAXAGSS.
OrthoDBiEOG091G0G6Z.
PhylomeDBiQ4V9P0.
TreeFamiTF313186.

Enzyme and pathway databases

ReactomeiR-DRE-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

PROiQ4V9P0.

Gene expression databases

BgeeiENSDARG00000058208.
ExpressionAtlasiQ4V9P0. differential.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAMC_DANRE
AccessioniPrimary (citable) accession number: Q4V9P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.