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Q4V9L6

- TM119_HUMAN

UniProt

Q4V9L6 - TM119_HUMAN

Protein

Transmembrane protein 119

Gene

TMEM119

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    May promote the differentiation of myoblasts into osteoblasts.By similarity

    GO - Biological processi

    1. osteoblast differentiation Source: Ensembl

    Keywords - Biological processi

    Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 119
    Alternative name(s):
    Osteoblast induction factor
    Short name:
    OBIF
    Gene namesi
    Name:TMEM119
    ORF Names:PSEC0199, UNQ731/PRO1415
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:27884. TMEM119.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 283258Transmembrane protein 119PRO_0000251220Add
    BLAST

    Proteomic databases

    MaxQBiQ4V9L6.
    PaxDbiQ4V9L6.
    PRIDEiQ4V9L6.

    PTM databases

    PhosphoSiteiQ4V9L6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4V9L6.
    BgeeiQ4V9L6.
    CleanExiHS_TMEM119.
    GenevestigatoriQ4V9L6.

    Organism-specific databases

    HPAiHPA051870.
    HPA052650.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000376553.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V9L6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 9671ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 283166CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42245.
    HOGENOMiHOG000060327.
    HOVERGENiHBG080787.
    InParanoidiQ4V9L6.
    OMAiQYVMLIA.
    OrthoDBiEOG7ZGX58.
    PhylomeDBiQ4V9L6.
    TreeFamiTF336958.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4V9L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSAAAPSLL ILLLLLLGSV PATDARSVPL KATFLEDVAG SGEAEGSSAS    50
    SPSLPPPWTP ALSPTSMGPQ PITLGGPSPP TNFLDGIVDF FRQYVMLIAV 100
    VGSLAFLLMF IVCAAVITRQ KQKASAYYPS SFPKKKYVDQ SDRAGGPRAF 150
    SEVPDRAPDS RPEEALDSSR QLQADILAAT QNLKSPTRAA LGGGDGARMV 200
    EGRGAEEEEK GSQEGDQEVQ GHGVPVETPE AQEEPCSGVL EGAVVAGEGQ 250
    GELEGSLLLA QEAQGPVGPP ESPCACSSVH PSV 283
    Length:283
    Mass (Da):29,203
    Last modified:July 5, 2005 - v1
    Checksum:i8676B7A11C06B569
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti262 – 2621E → G in BAC11656. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721I → T.2 Publications
    Corresponds to variant rs7975237 [ dbSNP | Ensembl ].
    VAR_027663

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358389 mRNA. Translation: AAQ88755.1.
    AK075501 mRNA. Translation: BAC11656.1.
    BC096825 mRNA. Translation: AAH96825.1.
    CCDSiCCDS9119.1.
    RefSeqiNP_859075.2. NM_181724.2.
    XP_006719431.1. XM_006719368.1.
    XP_006719432.1. XM_006719369.1.
    UniGeneiHs.449718.

    Genome annotation databases

    EnsembliENST00000392806; ENSP00000376553; ENSG00000183160.
    GeneIDi338773.
    KEGGihsa:338773.
    UCSCiuc001tng.3. human.

    Polymorphism databases

    DMDMi74754588.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358389 mRNA. Translation: AAQ88755.1 .
    AK075501 mRNA. Translation: BAC11656.1 .
    BC096825 mRNA. Translation: AAH96825.1 .
    CCDSi CCDS9119.1.
    RefSeqi NP_859075.2. NM_181724.2.
    XP_006719431.1. XM_006719368.1.
    XP_006719432.1. XM_006719369.1.
    UniGenei Hs.449718.

    3D structure databases

    ProteinModelPortali Q4V9L6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000376553.

    PTM databases

    PhosphoSitei Q4V9L6.

    Polymorphism databases

    DMDMi 74754588.

    Proteomic databases

    MaxQBi Q4V9L6.
    PaxDbi Q4V9L6.
    PRIDEi Q4V9L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392806 ; ENSP00000376553 ; ENSG00000183160 .
    GeneIDi 338773.
    KEGGi hsa:338773.
    UCSCi uc001tng.3. human.

    Organism-specific databases

    CTDi 338773.
    GeneCardsi GC12M108983.
    HGNCi HGNC:27884. TMEM119.
    HPAi HPA051870.
    HPA052650.
    neXtProti NX_Q4V9L6.
    PharmGKBi PA143485640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42245.
    HOGENOMi HOG000060327.
    HOVERGENi HBG080787.
    InParanoidi Q4V9L6.
    OMAi QYVMLIA.
    OrthoDBi EOG7ZGX58.
    PhylomeDBi Q4V9L6.
    TreeFami TF336958.

    Miscellaneous databases

    GenomeRNAii 338773.
    NextBioi 97151.
    PROi Q4V9L6.

    Gene expression databases

    ArrayExpressi Q4V9L6.
    Bgeei Q4V9L6.
    CleanExi HS_TMEM119.
    Genevestigatori Q4V9L6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Chondrosarcoma.

    Entry informationi

    Entry nameiTM119_HUMAN
    AccessioniPrimary (citable) accession number: Q4V9L6
    Secondary accession number(s): Q6UXE5, Q8N2F5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3