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Q4V9L6

- TM119_HUMAN

UniProt

Q4V9L6 - TM119_HUMAN

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Protein

Transmembrane protein 119

Gene

TMEM119

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May promote the differentiation of myoblasts into osteoblasts.By similarity

GO - Biological processi

  1. osteoblast differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 119
Alternative name(s):
Osteoblast induction factor
Short name:
OBIF
Gene namesi
Name:TMEM119
ORF Names:PSEC0199, UNQ731/PRO1415
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:27884. TMEM119.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 283258Transmembrane protein 119PRO_0000251220Add
BLAST

Proteomic databases

MaxQBiQ4V9L6.
PaxDbiQ4V9L6.
PRIDEiQ4V9L6.

PTM databases

PhosphoSiteiQ4V9L6.

Expressioni

Gene expression databases

BgeeiQ4V9L6.
CleanExiHS_TMEM119.
ExpressionAtlasiQ4V9L6. baseline and differential.
GenevestigatoriQ4V9L6.

Organism-specific databases

HPAiHPA051870.
HPA052650.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376553.

Structurei

3D structure databases

ProteinModelPortaliQ4V9L6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 9671ExtracellularSequence AnalysisAdd
BLAST
Topological domaini118 – 283166CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42245.
GeneTreeiENSGT00390000017134.
HOGENOMiHOG000060327.
HOVERGENiHBG080787.
InParanoidiQ4V9L6.
OMAiQYVMLIA.
OrthoDBiEOG7ZGX58.
PhylomeDBiQ4V9L6.
TreeFamiTF336958.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V9L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSAAAPSLL ILLLLLLGSV PATDARSVPL KATFLEDVAG SGEAEGSSAS
60 70 80 90 100
SPSLPPPWTP ALSPTSMGPQ PITLGGPSPP TNFLDGIVDF FRQYVMLIAV
110 120 130 140 150
VGSLAFLLMF IVCAAVITRQ KQKASAYYPS SFPKKKYVDQ SDRAGGPRAF
160 170 180 190 200
SEVPDRAPDS RPEEALDSSR QLQADILAAT QNLKSPTRAA LGGGDGARMV
210 220 230 240 250
EGRGAEEEEK GSQEGDQEVQ GHGVPVETPE AQEEPCSGVL EGAVVAGEGQ
260 270 280
GELEGSLLLA QEAQGPVGPP ESPCACSSVH PSV
Length:283
Mass (Da):29,203
Last modified:July 5, 2005 - v1
Checksum:i8676B7A11C06B569
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621E → G in BAC11656. (PubMed:16303743)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721I → T.2 Publications
Corresponds to variant rs7975237 [ dbSNP | Ensembl ].
VAR_027663

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358389 mRNA. Translation: AAQ88755.1.
AK075501 mRNA. Translation: BAC11656.1.
BC096825 mRNA. Translation: AAH96825.1.
CCDSiCCDS9119.1.
RefSeqiNP_859075.2. NM_181724.2.
XP_006719431.1. XM_006719368.1.
XP_006719432.1. XM_006719369.1.
UniGeneiHs.449718.

Genome annotation databases

EnsembliENST00000392806; ENSP00000376553; ENSG00000183160.
GeneIDi338773.
KEGGihsa:338773.
UCSCiuc001tng.3. human.

Polymorphism databases

DMDMi74754588.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358389 mRNA. Translation: AAQ88755.1 .
AK075501 mRNA. Translation: BAC11656.1 .
BC096825 mRNA. Translation: AAH96825.1 .
CCDSi CCDS9119.1.
RefSeqi NP_859075.2. NM_181724.2.
XP_006719431.1. XM_006719368.1.
XP_006719432.1. XM_006719369.1.
UniGenei Hs.449718.

3D structure databases

ProteinModelPortali Q4V9L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000376553.

PTM databases

PhosphoSitei Q4V9L6.

Polymorphism databases

DMDMi 74754588.

Proteomic databases

MaxQBi Q4V9L6.
PaxDbi Q4V9L6.
PRIDEi Q4V9L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392806 ; ENSP00000376553 ; ENSG00000183160 .
GeneIDi 338773.
KEGGi hsa:338773.
UCSCi uc001tng.3. human.

Organism-specific databases

CTDi 338773.
GeneCardsi GC12M108983.
HGNCi HGNC:27884. TMEM119.
HPAi HPA051870.
HPA052650.
neXtProti NX_Q4V9L6.
PharmGKBi PA143485640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42245.
GeneTreei ENSGT00390000017134.
HOGENOMi HOG000060327.
HOVERGENi HBG080787.
InParanoidi Q4V9L6.
OMAi QYVMLIA.
OrthoDBi EOG7ZGX58.
PhylomeDBi Q4V9L6.
TreeFami TF336958.

Miscellaneous databases

GenomeRNAii 338773.
NextBioi 97151.
PROi Q4V9L6.

Gene expression databases

Bgeei Q4V9L6.
CleanExi HS_TMEM119.
ExpressionAtlasi Q4V9L6. baseline and differential.
Genevestigatori Q4V9L6.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Chondrosarcoma.

Entry informationi

Entry nameiTM119_HUMAN
AccessioniPrimary (citable) accession number: Q4V9L6
Secondary accession number(s): Q6UXE5, Q8N2F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3