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Q4V9L6 (TM119_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 119
Alternative name(s):
Osteoblast induction factor
Short name=OBIF
Gene names
Name:TMEM119
ORF Names:PSEC0199, UNQ731/PRO1415
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May promote the differentiation of myoblasts into osteoblasts By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Ontologies

Keywords
   Biological processDifferentiation
Osteogenesis
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processosteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 283258Transmembrane protein 119
PRO_0000251220

Regions

Topological domain26 – 9671Extracellular Potential
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 283166Cytoplasmic Potential

Natural variations

Natural variant721I → T. Ref.1 Ref.2
Corresponds to variant rs7975237 [ dbSNP | Ensembl ].
VAR_027663

Experimental info

Sequence conflict2621E → G in BAC11656. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q4V9L6 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 8676B7A11C06B569

FASTA28329,203
        10         20         30         40         50         60 
MVSAAAPSLL ILLLLLLGSV PATDARSVPL KATFLEDVAG SGEAEGSSAS SPSLPPPWTP 

        70         80         90        100        110        120 
ALSPTSMGPQ PITLGGPSPP TNFLDGIVDF FRQYVMLIAV VGSLAFLLMF IVCAAVITRQ 

       130        140        150        160        170        180 
KQKASAYYPS SFPKKKYVDQ SDRAGGPRAF SEVPDRAPDS RPEEALDSSR QLQADILAAT 

       190        200        210        220        230        240 
QNLKSPTRAA LGGGDGARMV EGRGAEEEEK GSQEGDQEVQ GHGVPVETPE AQEEPCSGVL 

       250        260        270        280 
EGAVVAGEGQ GELEGSLLLA QEAQGPVGPP ESPCACSSVH PSV 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-72.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Chondrosarcoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358389 mRNA. Translation: AAQ88755.1.
AK075501 mRNA. Translation: BAC11656.1.
BC096825 mRNA. Translation: AAH96825.1.
CCDSCCDS9119.1.
RefSeqNP_859075.2. NM_181724.2.
XP_006719431.1. XM_006719368.1.
XP_006719432.1. XM_006719369.1.
UniGeneHs.449718.

3D structure databases

ProteinModelPortalQ4V9L6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000376553.

PTM databases

PhosphoSiteQ4V9L6.

Polymorphism databases

DMDM74754588.

Proteomic databases

MaxQBQ4V9L6.
PaxDbQ4V9L6.
PRIDEQ4V9L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000392806; ENSP00000376553; ENSG00000183160.
GeneID338773.
KEGGhsa:338773.
UCSCuc001tng.3. human.

Organism-specific databases

CTD338773.
GeneCardsGC12M108983.
HGNCHGNC:27884. TMEM119.
HPAHPA051870.
HPA052650.
neXtProtNX_Q4V9L6.
PharmGKBPA143485640.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42245.
HOGENOMHOG000060327.
HOVERGENHBG080787.
InParanoidQ4V9L6.
OMAQYVMLIA.
OrthoDBEOG7ZGX58.
PhylomeDBQ4V9L6.
TreeFamTF336958.

Gene expression databases

ArrayExpressQ4V9L6.
BgeeQ4V9L6.
CleanExHS_TMEM119.
GenevestigatorQ4V9L6.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi338773.
NextBio97151.
PROQ4V9L6.

Entry information

Entry nameTM119_HUMAN
AccessionPrimary (citable) accession number: Q4V9L6
Secondary accession number(s): Q6UXE5, Q8N2F5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM