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Protein

Receptor-interacting serine/threonine-protein kinase 2

Gene

ripk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571ATPUniRule annotation
Active sitei156 – 1561Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 429ATPUniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • CARD domain binding Source: ZFIN
  • protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Biological processi

Adaptive immunityUniRule annotation, Immunity, Innate immunityUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-interacting serine/threonine-protein kinase 2UniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Tyrosine-protein kinase RIPK2UniRule annotation
Gene namesi
Name:ripk2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030902-3. ripk2.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ4V958.

Interactioni

Subunit structurei

Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.UniRule annotation

GO - Molecular functioni

  • CARD domain binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043125.

Structurei

3D structure databases

ProteinModelPortaliQ4V958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 304277Protein kinaseInterPro annotationAdd
BLAST
Domaini465 – 55793CARDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000136856.
HOVERGENiHBG054242.
KOiK08846.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017322. Rcpt-int_Ser/Thr_kinase-2.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037921. STPK_RIP2. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRNMEHTGC VNICSLTSTL PVIPYRKLTD LHYISKGGFG TVFRAQHSDW
60 70 80 90 100
RTTVAIKCLK LDSPVGERER NCLLKEAEVL HKARFNHIIQ IFGVCNEPEF
110 120 130 140 150
FCIITEYMTN GSLDELLHEK DIYPAVAWPL RLRILYEIAL GVNFLHNMSP
160 170 180 190 200
PLLHHDLKTQ NILMDGEYHV KIADFGLSKW RQLSITKGSG SKPAEMGGTV
210 220 230 240 250
IYMPPEEYEP SKTRRTDVKY DMYSYAIIMW EVLSRRIPFE EATNPMQIMF
260 270 280 290 300
SVLRGARPDT GLDSLPVDIP SRETLINLMT SGWTANPDER PSFLHCLIEL
310 320 330 340 350
EPMLRRFDEI DVLEAVLEVK RIKYRRPSSC CSSTQSNGKK IEEKCVKELN
360 370 380 390 400
VPWPDNSSTS GSGSCSSQEA EISQPGFLTI STPSQGAYAG LPSSLMSLPL
410 420 430 440 450
DPPKPLMDNC SPNNLSPEYQ TAQVVSDLNI PFKAHAPHSE SELALAIQPL
460 470 480 490 500
TLHPHPQDFV TAFDDQGPAA RWIAARREEV VRQMTEACLN QSLDALLSRE
510 520 530 540 550
LLMREDYELV VNQTTRTAKV RKLLDTCERH SEEFCRVVVR KLQDNKQMGL
560 570 580
QPYPDLSTTS SPPSPYVAPS APFLSNSFNN TRNF
Length:584
Mass (Da):65,951
Last modified:July 5, 2005 - v1
Checksum:i147A224AC5535C8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097049 mRNA. Translation: AAH97049.1.
RefSeqiNP_919392.2. NM_194411.2.
UniGeneiDr.150902.

Genome annotation databases

GeneIDi373874.
KEGGidre:373874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097049 mRNA. Translation: AAH97049.1.
RefSeqiNP_919392.2. NM_194411.2.
UniGeneiDr.150902.

3D structure databases

ProteinModelPortaliQ4V958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043125.

Proteomic databases

PaxDbiQ4V958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373874.
KEGGidre:373874.

Organism-specific databases

CTDi8767.
ZFINiZDB-GENE-030902-3. ripk2.

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000136856.
HOVERGENiHBG054242.
KOiK08846.

Miscellaneous databases

NextBioi20813411.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017322. Rcpt-int_Ser/Thr_kinase-2.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037921. STPK_RIP2. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ4V958_DANRE
AccessioniPrimary (citable) accession number: Q4V958
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.