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Q4V908 (UBE2S_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
Name:ube2s
ORF Names:zgc:114060
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Ubiquitin-conjugating enzyme E2 S
PRO_0000390429

Sites

Active site951Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V908 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 3E3B6C7E6AC6B26D

FASTA22124,149
        10         20         30         40         50         60 
MNSNVENLPP QVLRLVYKEV SALAADPPEG IKIYPSEEDI TELHTSIEGP EGTPYAGGVF 

        70         80         90        100        110        120 
RMRLVLGKDF PAVPPRGYFL TKIFHPNVGH KGEICVNVLK RDWKAELGLR HVLLTIKCLL 

       130        140        150        160        170        180 
IHPNPESALN EEAGKLLLED YKEYASRAHL LTEIHAMGGT SGAPQEPADG PQPKKHAGDP 

       190        200        210        220 
NKRVVGAGLP TMGTGTNNSN ISNTNIVAKK KTDKKRALRR L 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097122 mRNA. Translation: AAH97122.1.
RefSeqNP_001020707.1. NM_001025536.1.
UniGeneDr.132389.

3D structure databases

ProteinModelPortalQ4V908.
SMRQ4V908. Positions 6-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000047451.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000047452; ENSDARP00000047451; ENSDARG00000031775.
GeneID565498.
KEGGdre:565498.

Organism-specific databases

ZFINZDB-GENE-050913-92. zgc:114060.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00730000110565.
HOGENOMHOG000233455.
HOVERGENHBG063308.
InParanoidQ4V908.
KOK10583.
OMAQICADIE.
OrthoDBEOG73JKXD.
PhylomeDBQ4V908.
TreeFamTF101120.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ4V908.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20885915.
PROQ4V908.

Entry information

Entry nameUBE2S_DANRE
AccessionPrimary (citable) accession number: Q4V908
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways