Reviewed, UniProtKB/Swiss-Prot Q4V8T0 (MIOX_DANRE)

Names and origin

Protein names

Recommended name:
    Inositol oxygenase
    EC=1.13.99.1
Alternative name(s):
    Myo-inositol oxygenase
      Short name=MI oxygenase

Gene names

Name:	miox
ORF Names:	zgc:114168

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Myo-inositol + O2 = D-glucuronate + H2O.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Polyol metabolism; myo-inositol degradation into D-glucuronic acid; D-glucuronic acid from myo-inositol: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol oxygenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol oxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Inositol oxygenase		PRO_0000079153
Sites
	Metal binding	91	1	Iron 1 By similarity
	Metal binding	116	1	Iron 1 By similarity
	Metal binding	117	1	Iron 1 By similarity
	Metal binding	117	1	Iron 2 By similarity
	Metal binding	187	1	Iron 2 By similarity
	Metal binding	213	1	Iron 2 By similarity
	Metal binding	246	1	Iron 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V8T0-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 77473AF42E647FD0	FASTA	278	32,735
	10 20 30 40 50 60 MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK QKHQVWSNCS 70 80 90 100 110 120 HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR REHPDKDWFQ LVGLIHDVGK 130 140 150 160 170 180 VMALYSEPQW AVVGDTYPVG CKFQNSIVFR NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK 190 200 210 220 230 240 VLMSWGHDEY LYRVMKFNKC TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK 250 260 270 EFNKFDLYTK STELPDVERL KPYYQSLIDK YCPGVLQW

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Larva.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC097218 mRNA. Translation: AAH97218.1.
IPI	IPI00507322.
RefSeq	NP_001025437.1.
UniGene	Dr.90253
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000002764. Danio rerio. [Contig view]
GeneID	571850.
KEGG	dre:571850.
Organism-specific databases
ZFIN	ZDB-GENE-050913-113. zgc:114168.
Phylogenomic databases
HOGENOM	Q4V8T0.
HOVERGEN	Q4V8T0.
Enzyme and pathway databases
BRENDA	1.13.99.1. 96826.
Gene expression databases
Bgee	Q4V8T0.
Family and domain databases
InterPro	IPR007828. DUF706. [Graphical view]
PANTHER	PTHR12588. DUF706. 1 hit.
Pfam	PF05153. DUF706. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MIOX_DANRE

Accession

Primary (citable) accession number: Q4V8T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project