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Protein

Inositol oxygenase

Gene

miox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221SubstrateBy similarity
Metal bindingi91 – 911Iron 1By similarity
Metal bindingi116 – 1161Iron 1By similarity
Metal bindingi117 – 1171Iron 1By similarity
Metal bindingi117 – 1171Iron 2By similarity
Binding sitei120 – 1201SubstrateBy similarity
Metal bindingi187 – 1871Iron 2By similarity
Metal bindingi213 – 2131Iron 2By similarity
Metal bindingi246 – 2461Iron 1By similarity

GO - Molecular functioni

  1. ferric iron binding Source: UniProtKB
  2. inositol oxygenase activity Source: UniProtKB

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:miox
ORF Names:zgc:114168
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050913-113. miox.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Inositol oxygenasePRO_0000079153Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4V8T0.
SMRiQ4V8T0. Positions 21-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 803Substrate bindingBy similarity
Regioni134 – 1352Substrate bindingBy similarity
Regioni213 – 2142Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiNOG135479.
HOVERGENiHBG039556.
InParanoidiQ4V8T0.
KOiK00469.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK
60 70 80 90 100
QKHQVWSNCS HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR
110 120 130 140 150
REHPDKDWFQ LVGLIHDVGK VMALYSEPQW AVVGDTYPVG CKFQNSIVFR
160 170 180 190 200
NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK VLMSWGHDEY LYRVMKFNKC
210 220 230 240 250
TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK EFNKFDLYTK
260 270
STELPDVERL KPYYQSLIDK YCPGVLQW
Length:278
Mass (Da):32,735
Last modified:July 4, 2005 - v1
Checksum:i77473AF42E647FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097218 mRNA. Translation: AAH97218.1.
RefSeqiNP_001025437.1. NM_001030266.1.
UniGeneiDr.90253.

Genome annotation databases

GeneIDi571850.
KEGGidre:571850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097218 mRNA. Translation: AAH97218.1.
RefSeqiNP_001025437.1. NM_001030266.1.
UniGeneiDr.90253.

3D structure databases

ProteinModelPortaliQ4V8T0.
SMRiQ4V8T0. Positions 21-278.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi571850.
KEGGidre:571850.

Organism-specific databases

CTDi55586.
ZFINiZDB-GENE-050913-113. miox.

Phylogenomic databases

eggNOGiNOG135479.
HOVERGENiHBG039556.
InParanoidiQ4V8T0.
KOiK00469.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Miscellaneous databases

NextBioi20890725.
PROiQ4V8T0.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.

Entry informationi

Entry nameiMIOX_DANRE
AccessioniPrimary (citable) accession number: Q4V8T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2005
Last sequence update: July 4, 2005
Last modified: January 6, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.