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Q4V8T0

- MIOX_DANRE

UniProt

Q4V8T0 - MIOX_DANRE

Protein

Inositol oxygenase

Gene

miox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221SubstrateBy similarity
    Metal bindingi91 – 911Iron 1By similarity
    Metal bindingi116 – 1161Iron 1By similarity
    Metal bindingi117 – 1171Iron 1By similarity
    Metal bindingi117 – 1171Iron 2By similarity
    Binding sitei120 – 1201SubstrateBy similarity
    Metal bindingi187 – 1871Iron 2By similarity
    Metal bindingi213 – 2131Iron 2By similarity
    Metal bindingi246 – 2461Iron 1By similarity

    GO - Molecular functioni

    1. ferric iron binding Source: UniProtKB
    2. inositol oxygenase activity Source: UniProtKB

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Gene namesi
    Name:miox
    ORF Names:zgc:114168
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-050913-113. miox.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Inositol oxygenasePRO_0000079153Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V8T0.
    SMRiQ4V8T0. Positions 21-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni78 – 803Substrate bindingBy similarity
    Regioni134 – 1352Substrate bindingBy similarity
    Regioni213 – 2142Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG135479.
    HOVERGENiHBG039556.
    InParanoidiQ4V8T0.
    KOiK00469.

    Family and domain databases

    InterProiIPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4V8T0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK    50
    QKHQVWSNCS HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR 100
    REHPDKDWFQ LVGLIHDVGK VMALYSEPQW AVVGDTYPVG CKFQNSIVFR 150
    NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK VLMSWGHDEY LYRVMKFNKC 200
    TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK EFNKFDLYTK 250
    STELPDVERL KPYYQSLIDK YCPGVLQW 278
    Length:278
    Mass (Da):32,735
    Last modified:July 5, 2005 - v1
    Checksum:i77473AF42E647FD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097218 mRNA. Translation: AAH97218.1.
    RefSeqiNP_001025437.1. NM_001030266.1.
    UniGeneiDr.90253.

    Genome annotation databases

    GeneIDi571850.
    KEGGidre:571850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097218 mRNA. Translation: AAH97218.1 .
    RefSeqi NP_001025437.1. NM_001030266.1.
    UniGenei Dr.90253.

    3D structure databases

    ProteinModelPortali Q4V8T0.
    SMRi Q4V8T0. Positions 21-278.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 571850.
    KEGGi dre:571850.

    Organism-specific databases

    CTDi 55586.
    ZFINi ZDB-GENE-050913-113. miox.

    Phylogenomic databases

    eggNOGi NOG135479.
    HOVERGENi HBG039556.
    InParanoidi Q4V8T0.
    KOi K00469.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .

    Miscellaneous databases

    NextBioi 20890725.
    PROi Q4V8T0.

    Family and domain databases

    InterProi IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Larva.

    Entry informationi

    Entry nameiMIOX_DANRE
    AccessioniPrimary (citable) accession number: Q4V8T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3