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Q4V8T0 (MIOX_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Myo-inositol oxygenase
Short name=MI oxygenase
Gene names
Name:miox
ORF Names:zgc:114168
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

inositol oxygenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Inositol oxygenase
PRO_0000079153

Regions

Region78 – 803Substrate binding By similarity
Region134 – 1352Substrate binding By similarity
Region213 – 2142Substrate binding By similarity

Sites

Metal binding911Iron 1 By similarity
Metal binding1161Iron 1 By similarity
Metal binding1171Iron 1 By similarity
Metal binding1171Iron 2 By similarity
Metal binding1871Iron 2 By similarity
Metal binding2131Iron 2 By similarity
Metal binding2461Iron 1 By similarity
Binding site221Substrate By similarity
Binding site1201Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V8T0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 77473AF42E647FD0

FASTA27832,735
        10         20         30         40         50         60 
MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK QKHQVWSNCS 

        70         80         90        100        110        120 
HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR REHPDKDWFQ LVGLIHDVGK 

       130        140        150        160        170        180 
VMALYSEPQW AVVGDTYPVG CKFQNSIVFR NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK 

       190        200        210        220        230        240 
VLMSWGHDEY LYRVMKFNKC TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK 

       250        260        270 
EFNKFDLYTK STELPDVERL KPYYQSLIDK YCPGVLQW 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Larva.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097218 mRNA. Translation: AAH97218.1.
RefSeqNP_001025437.1. NM_001030266.1.
UniGeneDr.90253.

3D structure databases

ProteinModelPortalQ4V8T0.
SMRQ4V8T0. Positions 21-278.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID571850.
KEGGdre:571850.

Organism-specific databases

CTD55586.
ZFINZDB-GENE-050913-113. miox.

Phylogenomic databases

eggNOGNOG135479.
HOVERGENHBG039556.
InParanoidQ4V8T0.
KOK00469.

Enzyme and pathway databases

UniPathwayUPA00111; UER00527.

Family and domain databases

InterProIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20890725.
PROQ4V8T0.

Entry information

Entry nameMIOX_DANRE
AccessionPrimary (citable) accession number: Q4V8T0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2005
Last modified: January 22, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways