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Protein

Inositol oxygenase

Gene

miox

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: myo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Inositol oxygenase (miox)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22SubstrateBy similarity1
Metal bindingi91Iron 1By similarity1
Metal bindingi116Iron 1By similarity1
Metal bindingi117Iron 1By similarity1
Metal bindingi117Iron 2By similarity1
Binding sitei120SubstrateBy similarity1
Metal bindingi187Iron 2By similarity1
Metal bindingi213Iron 2By similarity1
Metal bindingi246Iron 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:miox
ORF Names:zgc:114168
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050913-113. miox.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791531 – 278Inositol oxygenaseAdd BLAST278

Proteomic databases

PaxDbiQ4V8T0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000115890.

Structurei

3D structure databases

ProteinModelPortaliQ4V8T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni78 – 80Substrate bindingBy similarity3
Regioni134 – 135Substrate bindingBy similarity2
Regioni213 – 214Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1573. Eukaryota.
ENOG410XQ4J. LUCA.
HOVERGENiHBG039556.
InParanoidiQ4V8T0.
KOiK00469.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. MIOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPDPSLAYR PECHEKDKTE FRNFENGDLF DRVFNTYKLM HTHQTLDFVK
60 70 80 90 100
QKHQVWSNCS HFSLSMMDSI DSLDELVDES DPDVDFPNSF HAFQTAEGIR
110 120 130 140 150
REHPDKDWFQ LVGLIHDVGK VMALYSEPQW AVVGDTYPVG CKFQNSIVFR
160 170 180 190 200
NSTFEGNPDG KNPAPNTEFG IYEPQCGLDK VLMSWGHDEY LYRVMKFNKC
210 220 230 240 250
TIPEEGLYMI RFHSFYPWHS NGDYMHLCNE KDQQMLPWVK EFNKFDLYTK
260 270
STELPDVERL KPYYQSLIDK YCPGVLQW
Length:278
Mass (Da):32,735
Last modified:July 5, 2005 - v1
Checksum:i77473AF42E647FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097218 mRNA. Translation: AAH97218.1.
RefSeqiNP_001025437.1. NM_001030266.1.
UniGeneiDr.90253.

Genome annotation databases

GeneIDi571850.
KEGGidre:571850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097218 mRNA. Translation: AAH97218.1.
RefSeqiNP_001025437.1. NM_001030266.1.
UniGeneiDr.90253.

3D structure databases

ProteinModelPortaliQ4V8T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000115890.

Proteomic databases

PaxDbiQ4V8T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi571850.
KEGGidre:571850.

Organism-specific databases

CTDi55586.
ZFINiZDB-GENE-050913-113. miox.

Phylogenomic databases

eggNOGiKOG1573. Eukaryota.
ENOG410XQ4J. LUCA.
HOVERGENiHBG039556.
InParanoidiQ4V8T0.
KOiK00469.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Miscellaneous databases

PROiQ4V8T0.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. MIOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIOX_DANRE
AccessioniPrimary (citable) accession number: Q4V8T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2005
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.