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Protein

Solute carrier family 25 member 39

Gene

Slc25a39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
Name:Slc25a39
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306193. Slc25a39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Solute carrier family 25 member 39PRO_0000289722Add
BLAST

Proteomic databases

PaxDbiQ4V8K4.
PRIDEiQ4V8K4.

PTM databases

iPTMnetiQ4V8K4.
PhosphoSiteiQ4V8K4.

Expressioni

Gene expression databases

GenevisibleiQ4V8K4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028496.

Structurei

3D structure databases

ProteinModelPortaliQ4V8K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 151143Solcar 1Add
BLAST
Repeati159 – 24385Solcar 2Add
BLAST
Repeati253 – 34795Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ4V8K4.
KOiK15119.
OMAiYCSGVLE.
OrthoDBiEOG79KPFV.
PhylomeDBiQ4V8K4.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPTVASEL
60 70 80 90 100
TTPSRFWSLS YTKSPSTLQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD
110 120 130 140 150
PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA
160 170 180 190 200
FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA
210 220 230 240 250
ACVQAAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSQLNGPRQK
260 270 280 290 300
EQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAMRVKPPRV
310 320 330 340 350
DSTWLLLRRI QAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFHR

LNQEQPLGH
Length:359
Mass (Da):39,235
Last modified:July 5, 2005 - v1
Checksum:iFD0948440E00195E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097349 mRNA. Translation: AAH97349.1.
RefSeqiNP_001019963.1. NM_001024792.1.
XP_006247436.1. XM_006247374.2.
XP_006247438.1. XM_006247376.2.
UniGeneiRn.55537.

Genome annotation databases

EnsembliENSRNOT00000028496; ENSRNOP00000028496; ENSRNOG00000020994.
GeneIDi360636.
KEGGirno:360636.
UCSCiRGD:1306193. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097349 mRNA. Translation: AAH97349.1.
RefSeqiNP_001019963.1. NM_001024792.1.
XP_006247436.1. XM_006247374.2.
XP_006247438.1. XM_006247376.2.
UniGeneiRn.55537.

3D structure databases

ProteinModelPortaliQ4V8K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028496.

PTM databases

iPTMnetiQ4V8K4.
PhosphoSiteiQ4V8K4.

Proteomic databases

PaxDbiQ4V8K4.
PRIDEiQ4V8K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028496; ENSRNOP00000028496; ENSRNOG00000020994.
GeneIDi360636.
KEGGirno:360636.
UCSCiRGD:1306193. rat.

Organism-specific databases

CTDi51629.
RGDi1306193. Slc25a39.

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ4V8K4.
KOiK15119.
OMAiYCSGVLE.
OrthoDBiEOG79KPFV.
PhylomeDBiQ4V8K4.
TreeFamiTF314720.

Miscellaneous databases

PROiQ4V8K4.

Gene expression databases

GenevisibleiQ4V8K4. RN.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiS2539_RAT
AccessioniPrimary (citable) accession number: Q4V8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.