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Protein

Solute carrier family 25 member 39

Gene

Slc25a39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306193. Slc25a39.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei256 – 276Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei318 – 338Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897221 – 359Solute carrier family 25 member 39Add BLAST359

Proteomic databases

PaxDbiQ4V8K4.
PRIDEiQ4V8K4.

PTM databases

iPTMnetiQ4V8K4.
PhosphoSitePlusiQ4V8K4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020994.
GenevisibleiQ4V8K4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028496.

Structurei

3D structure databases

ProteinModelPortaliQ4V8K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 151Solcar 1Add BLAST143
Repeati159 – 243Solcar 2Add BLAST85
Repeati253 – 347Solcar 3Add BLAST95

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ4V8K4.
KOiK15119.
OMAiYCSGVLE.
OrthoDBiEOG091G07QQ.
PhylomeDBiQ4V8K4.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPTVASEL
60 70 80 90 100
TTPSRFWSLS YTKSPSTLQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD
110 120 130 140 150
PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA
160 170 180 190 200
FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA
210 220 230 240 250
ACVQAAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSQLNGPRQK
260 270 280 290 300
EQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAMRVKPPRV
310 320 330 340 350
DSTWLLLRRI QAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFHR

LNQEQPLGH
Length:359
Mass (Da):39,235
Last modified:July 5, 2005 - v1
Checksum:iFD0948440E00195E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097349 mRNA. Translation: AAH97349.1.
RefSeqiNP_001019963.1. NM_001024792.1.
XP_006247436.1. XM_006247374.3.
XP_006247438.1. XM_006247376.2.
UniGeneiRn.55537.

Genome annotation databases

EnsembliENSRNOT00000028496; ENSRNOP00000028496; ENSRNOG00000020994.
GeneIDi360636.
KEGGirno:360636.
UCSCiRGD:1306193. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097349 mRNA. Translation: AAH97349.1.
RefSeqiNP_001019963.1. NM_001024792.1.
XP_006247436.1. XM_006247374.3.
XP_006247438.1. XM_006247376.2.
UniGeneiRn.55537.

3D structure databases

ProteinModelPortaliQ4V8K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028496.

PTM databases

iPTMnetiQ4V8K4.
PhosphoSitePlusiQ4V8K4.

Proteomic databases

PaxDbiQ4V8K4.
PRIDEiQ4V8K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028496; ENSRNOP00000028496; ENSRNOG00000020994.
GeneIDi360636.
KEGGirno:360636.
UCSCiRGD:1306193. rat.

Organism-specific databases

CTDi51629.
RGDi1306193. Slc25a39.

Phylogenomic databases

eggNOGiKOG0761. Eukaryota.
ENOG410XQVP. LUCA.
GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ4V8K4.
KOiK15119.
OMAiYCSGVLE.
OrthoDBiEOG091G07QQ.
PhylomeDBiQ4V8K4.
TreeFamiTF314720.

Miscellaneous databases

PROiQ4V8K4.

Gene expression databases

BgeeiENSRNOG00000020994.
GenevisibleiQ4V8K4. RN.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2539_RAT
AccessioniPrimary (citable) accession number: Q4V8K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.