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Protein

N-alpha-acetyltransferase 11

Gene

Naa11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 11 (EC:2.3.1.88)
Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
NatA catalytic subunit Naa11
Gene namesi
Name:Naa11
Synonyms:Ard1b, Ard2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1564723. Naa11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246N-alpha-acetyltransferase 11PRO_0000305011Add
BLAST

Proteomic databases

PaxDbiQ4V8K3.
PRIDEiQ4V8K3.

PTM databases

iPTMnetiQ4V8K3.
PhosphoSiteiQ4V8K3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002031.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15. Interacts with HIF1A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002776.

Structurei

3D structure databases

ProteinModelPortaliQ4V8K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 152152N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5858Interaction with NAA15By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3235. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00550000074803.
HOVERGENiHBG050561.
InParanoidiQ4V8K3.
KOiK00670.
OMAiQPENPAG.
OrthoDBiEOG091G0JI1.
PhylomeDBiQ4V8K3.
TreeFamiTF300078.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDEDG
60 70 80 90 100
KIVGYVLAKM EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE
110 120 130 140 150
NFSAKYVSLH VRKSNRAALH LYSNTLNFQV SEVEPKYYAD GEDAYAMKRD
160 170 180 190 200
LAQMADELRR QLVLKKSRYV VLGSEENQEA QDSTLPDAEE ACQPENPAGK
210 220 230 240
GSEACQPENP AGKGSEACQP ENPAGKDTGS HSTDVQDSSE YLDSTS
Length:246
Mass (Da):27,623
Last modified:July 5, 2005 - v1
Checksum:i7A2D6376A95F1483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097350 mRNA. Translation: AAH97350.1.
RefSeqiNP_001019913.1. NM_001024742.1.
UniGeneiRn.125240.

Genome annotation databases

EnsembliENSRNOT00000002776; ENSRNOP00000002776; ENSRNOG00000002031.
GeneIDi289482.
KEGGirno:289482.
UCSCiRGD:1564723. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097350 mRNA. Translation: AAH97350.1.
RefSeqiNP_001019913.1. NM_001024742.1.
UniGeneiRn.125240.

3D structure databases

ProteinModelPortaliQ4V8K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002776.

PTM databases

iPTMnetiQ4V8K3.
PhosphoSiteiQ4V8K3.

Proteomic databases

PaxDbiQ4V8K3.
PRIDEiQ4V8K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002776; ENSRNOP00000002776; ENSRNOG00000002031.
GeneIDi289482.
KEGGirno:289482.
UCSCiRGD:1564723. rat.

Organism-specific databases

CTDi84779.
RGDi1564723. Naa11.

Phylogenomic databases

eggNOGiKOG3235. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00550000074803.
HOVERGENiHBG050561.
InParanoidiQ4V8K3.
KOiK00670.
OMAiQPENPAG.
OrthoDBiEOG091G0JI1.
PhylomeDBiQ4V8K3.
TreeFamiTF300078.

Miscellaneous databases

PROiQ4V8K3.

Gene expression databases

BgeeiENSRNOG00000002031.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA11_RAT
AccessioniPrimary (citable) accession number: Q4V8K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.