Q4V8K3 (NAA11_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 11
EC=2.3.1.88

Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
NatA catalytic subunit

Gene names

Name:	Naa11
Synonyms:	Ard1b, Ard2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NAA15 and HIF1A By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptide alpha-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	N-alpha-acetyltransferase 11		PRO_0000305011
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NAA15 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V8K3 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 7A2D6376A95F1483	FASTA	246	27,623
	10 20 30 40 50 60 MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFSAKYVSLH VRKSNRAALH 130 140 150 160 170 180 LYSNTLNFQV SEVEPKYYAD GEDAYAMKRD LAQMADELRR QLVLKKSRYV VLGSEENQEA 190 200 210 220 230 240 QDSTLPDAEE ACQPENPAGK GSEACQPENP AGKGSEACQP ENPAGKDTGS HSTDVQDSSE YLDSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097350 mRNA. Translation: AAH97350.1.
IPI	IPI00196410.
RefSeq	NP_001019913.1. NM_001024742.1.
UniGene	Rn.125240.
3D structure databases
ProteinModelPortal	Q4V8K3.
ModBase	Search...
Proteomic databases
PRIDE	Q4V8K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002776; ENSRNOP00000002776; ENSRNOG00000002031.
GeneID	289482.
KEGG	rno:289482.
UCSC	RGD:1564723. rat.
Organism-specific databases
CTD	84779.
RGD	1564723. Naa11.
Phylogenomic databases
eggNOG	COG0456.
GeneTree	ENSGT00550000074803.
HOVERGEN	HBG050561.
InParanoid	Q4V8K3.
KO	K00670.
OMA	EACQPEN.
OrthoDB	EOG4Z0B6F.
Gene expression databases
Genevestigator	Q4V8K3.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GNAT_dom. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	629881.

Entry information

Entry name

NAA11_RAT

Accession

Primary (citable) accession number: Q4V8K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program