Reviewed, UniProtKB/Swiss-Prot Q4V8K3 (ARD1B_RAT)

Names and origin

Protein names

Recommended name:
    N-terminal acetyltransferase complex ARD1 subunit homolog B
    EC=2.3.1.88

Gene names

Name:	Ard1b
Synonyms:	Ard2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	In complex with NARG1, displays alpha (N-terminal) acetyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NARG1 and HIF1A By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide alpha-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	N-terminal acetyltransferase complex ARD1 subunit homolog B		PRO_0000305011
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NARG1 By similarity
Amino acid modifications
	Modified residue	136	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V8K3-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 7A2D6376A95F1483	FASTA	246	27,623
	10 20 30 40 50 60 MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFSAKYVSLH VRKSNRAALH 130 140 150 160 170 180 LYSNTLNFQV SEVEPKYYAD GEDAYAMKRD LAQMADELRR QLVLKKSRYV VLGSEENQEA 190 200 210 220 230 240 QDSTLPDAEE ACQPENPAGK GSEACQPENP AGKGSEACQP ENPAGKDTGS HSTDVQDSSE YLDSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed: 16638120] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC097350 mRNA. Translation: AAH97350.1.
IPI	IPI00196410.
RefSeq	NP_001019913.1.
UniGene	Rn.125240
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002776; ENSRNOP00000002776; ENSRNOG00000002031; Rattus norvegicus. [Genome view]
GeneID	289482.
KEGG	rno:289482.
NMPDR	fig|10116.3.peg.10059.
UCSC	NM_001024742. rat.
Organism-specific databases
CTD	289482.
RGD	1564723. LOC289482.
Phylogenomic databases
HOVERGEN	Q4V8K3.
OMA	EACQPEN.
Enzyme and pathway databases
BRENDA	2.3.1.88. 248.
Gene expression databases
Genevestigator	Q4V8K3.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	629881.

Entry information

Entry name

ARD1B_RAT

Accession

Primary (citable) accession number: Q4V8K3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 5, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)