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Protein

Metalloreductase STEAP4

Gene

Steap4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi304 – 3041Iron (heme axial ligand)By similarity
Metal bindingi397 – 3971Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP4 (EC:1.16.1.-)
Alternative name(s):
Six-transmembrane epithelial antigen of prostate 4
Gene namesi
Name:Steap4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1560331. Steap4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40118HelicalSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Metalloreductase STEAP4PRO_0000285176Add
BLAST

Proteomic databases

PaxDbiQ4V8K1.
PRIDEiQ4V8K1.

PTM databases

PhosphoSiteiQ4V8K1.

Expressioni

Gene expression databases

ExpressionAtlasiQ4V8K1. baseline and differential.
GenevisibleiQ4V8K1. RN.

Interactioni

Subunit structurei

Interacts with and phosphorylates PTK2/FAK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011432.

Structurei

Secondary structure

1
470
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 255Combined sources
Helixi29 – 4012Combined sources
Beta strandi44 – 507Combined sources
Beta strandi62 – 665Combined sources
Helixi67 – 726Combined sources
Beta strandi75 – 795Combined sources
Helixi83 – 853Combined sources
Helixi87 – 9610Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi112 – 1154Combined sources
Helixi117 – 1248Combined sources
Beta strandi128 – 1325Combined sources
Helixi141 – 1444Combined sources
Beta strandi152 – 1587Combined sources
Helixi160 – 17213Combined sources
Beta strandi176 – 1794Combined sources
Helixi183 – 1853Combined sources
Helixi186 – 1916Combined sources
Helixi192 – 1943Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YJZX-ray2.20A/B/C/D1-195[»]
ProteinModelPortaliQ4V8K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini247 – 395149Ferric oxidoreductaseAdd
BLAST

Sequence similaritiesi

Belongs to the STEAP family.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF4F. Eukaryota.
COG2085. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000234491.
HOVERGENiHBG054379.
InParanoidiQ4V8K1.
KOiK19876.
OMAiYCVIREV.
PhylomeDBiQ4V8K1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view]
PfamiPF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTCADEFP LTVDSSEKQG VVCIFGTGDF GKSLGLKMLQ CGYSVVFGSR
60 70 80 90 100
NPQVSSLLPR GAEVLCYSEA ASRSDVIVLA VHREHYDFLA ELADSLKGRV
110 120 130 140 150
LIDVSNNQKM NQYPESNAEY LAQLVPGAHV VKAFNTISAW ALQSGTLDAS
160 170 180 190 200
RQVFVCGNDS KAKDRVMDIA RTLGLTPLDQ GSLVAAKEIE NYPLQLFPMW
210 220 230 240 250
RFPFYLSSGL CVFFFVYCAI REVIYPYVTG KTDSTYRLVV SIPNRVFPIT
260 270 280 290 300
ALTLLALVYL PGILAAILQL YRGTKYRRFP NWLDHWMLCR KQLGLVALGF
310 320 330 340 350
AFLHAIYTLV IPIRYYVRWR LRNATITQAL TNKDSPFSSS TAWLSDSYLA
360 370 380 390 400
LGILGFFLFL LLGITSLPSV SNMVNWREFR FVQSKLGYLT LVLCTAHTLV
410 420 430 440 450
YGGKRFLSPS ILIWSLPSAY ILALIIPCTV LVMKFILIMP CIDKTLTRIR
460 470
QGWERKSKYA QSTLNGKSDI
Length:470
Mass (Da):52,765
Last modified:July 5, 2005 - v1
Checksum:iC2323082CB3B6465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097353 mRNA. Translation: AAH97353.1.
RefSeqiNP_001037730.1. NM_001044265.1.
UniGeneiRn.16959.

Genome annotation databases

EnsembliENSRNOT00000011432; ENSRNOP00000011432; ENSRNOG00000008602.
GeneIDi499991.
KEGGirno:499991.
UCSCiRGD:1560331. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097353 mRNA. Translation: AAH97353.1.
RefSeqiNP_001037730.1. NM_001044265.1.
UniGeneiRn.16959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YJZX-ray2.20A/B/C/D1-195[»]
ProteinModelPortaliQ4V8K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011432.

PTM databases

PhosphoSiteiQ4V8K1.

Proteomic databases

PaxDbiQ4V8K1.
PRIDEiQ4V8K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011432; ENSRNOP00000011432; ENSRNOG00000008602.
GeneIDi499991.
KEGGirno:499991.
UCSCiRGD:1560331. rat.

Organism-specific databases

CTDi79689.
RGDi1560331. Steap4.

Phylogenomic databases

eggNOGiENOG410IF4F. Eukaryota.
COG2085. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000234491.
HOVERGENiHBG054379.
InParanoidiQ4V8K1.
KOiK19876.
OMAiYCVIREV.
PhylomeDBiQ4V8K1.

Miscellaneous databases

PROiQ4V8K1.

Gene expression databases

ExpressionAtlasiQ4V8K1. baseline and differential.
GenevisibleiQ4V8K1. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view]
PfamiPF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiSTEA4_RAT
AccessioniPrimary (citable) accession number: Q4V8K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.