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Protein

Metalloreductase STEAP4

Gene

Steap4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi304Iron (heme axial ligand)By similarity1
Metal bindingi397Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP4 (EC:1.16.1.-)
Alternative name(s):
Six-transmembrane epithelial antigen of prostate 4
Gene namesi
Name:Steap4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1560331. Steap4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei384 – 401HelicalSequence analysisAdd BLAST18
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851761 – 470Metalloreductase STEAP4Add BLAST470

Proteomic databases

PaxDbiQ4V8K1.
PRIDEiQ4V8K1.

PTM databases

PhosphoSitePlusiQ4V8K1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008602.
ExpressionAtlasiQ4V8K1. baseline and differential.
GenevisibleiQ4V8K1. RN.

Interactioni

Subunit structurei

Interacts with and phosphorylates PTK2/FAK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011432.

Structurei

Secondary structure

1470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 25Combined sources5
Helixi29 – 40Combined sources12
Beta strandi44 – 50Combined sources7
Beta strandi62 – 66Combined sources5
Helixi67 – 72Combined sources6
Beta strandi75 – 79Combined sources5
Helixi83 – 85Combined sources3
Helixi87 – 96Combined sources10
Beta strandi100 – 103Combined sources4
Beta strandi112 – 115Combined sources4
Helixi117 – 124Combined sources8
Beta strandi128 – 132Combined sources5
Helixi141 – 144Combined sources4
Beta strandi152 – 158Combined sources7
Helixi160 – 172Combined sources13
Beta strandi176 – 179Combined sources4
Helixi183 – 185Combined sources3
Helixi186 – 191Combined sources6
Helixi192 – 194Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YJZX-ray2.20A/B/C/D1-195[»]
ProteinModelPortaliQ4V8K1.
SMRiQ4V8K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 395Ferric oxidoreductaseAdd BLAST149

Sequence similaritiesi

Belongs to the STEAP family.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF4F. Eukaryota.
COG2085. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000234491.
HOVERGENiHBG054379.
InParanoidiQ4V8K1.
KOiK19876.
OMAiYCVIREV.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ4V8K1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view]
PfamiPF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTCADEFP LTVDSSEKQG VVCIFGTGDF GKSLGLKMLQ CGYSVVFGSR
60 70 80 90 100
NPQVSSLLPR GAEVLCYSEA ASRSDVIVLA VHREHYDFLA ELADSLKGRV
110 120 130 140 150
LIDVSNNQKM NQYPESNAEY LAQLVPGAHV VKAFNTISAW ALQSGTLDAS
160 170 180 190 200
RQVFVCGNDS KAKDRVMDIA RTLGLTPLDQ GSLVAAKEIE NYPLQLFPMW
210 220 230 240 250
RFPFYLSSGL CVFFFVYCAI REVIYPYVTG KTDSTYRLVV SIPNRVFPIT
260 270 280 290 300
ALTLLALVYL PGILAAILQL YRGTKYRRFP NWLDHWMLCR KQLGLVALGF
310 320 330 340 350
AFLHAIYTLV IPIRYYVRWR LRNATITQAL TNKDSPFSSS TAWLSDSYLA
360 370 380 390 400
LGILGFFLFL LLGITSLPSV SNMVNWREFR FVQSKLGYLT LVLCTAHTLV
410 420 430 440 450
YGGKRFLSPS ILIWSLPSAY ILALIIPCTV LVMKFILIMP CIDKTLTRIR
460 470
QGWERKSKYA QSTLNGKSDI
Length:470
Mass (Da):52,765
Last modified:July 5, 2005 - v1
Checksum:iC2323082CB3B6465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097353 mRNA. Translation: AAH97353.1.
RefSeqiNP_001037730.1. NM_001044265.1.
UniGeneiRn.16959.

Genome annotation databases

EnsembliENSRNOT00000011432; ENSRNOP00000011432; ENSRNOG00000008602.
GeneIDi499991.
KEGGirno:499991.
UCSCiRGD:1560331. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097353 mRNA. Translation: AAH97353.1.
RefSeqiNP_001037730.1. NM_001044265.1.
UniGeneiRn.16959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YJZX-ray2.20A/B/C/D1-195[»]
ProteinModelPortaliQ4V8K1.
SMRiQ4V8K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011432.

PTM databases

PhosphoSitePlusiQ4V8K1.

Proteomic databases

PaxDbiQ4V8K1.
PRIDEiQ4V8K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011432; ENSRNOP00000011432; ENSRNOG00000008602.
GeneIDi499991.
KEGGirno:499991.
UCSCiRGD:1560331. rat.

Organism-specific databases

CTDi79689.
RGDi1560331. Steap4.

Phylogenomic databases

eggNOGiENOG410IF4F. Eukaryota.
COG2085. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000234491.
HOVERGENiHBG054379.
InParanoidiQ4V8K1.
KOiK19876.
OMAiYCVIREV.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ4V8K1.

Miscellaneous databases

PROiQ4V8K1.

Gene expression databases

BgeeiENSRNOG00000008602.
ExpressionAtlasiQ4V8K1. baseline and differential.
GenevisibleiQ4V8K1. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013130. Fe3_Rdtase_TM_dom.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
[Graphical view]
PfamiPF03807. F420_oxidored. 1 hit.
PF01794. Ferric_reduct. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTEA4_RAT
AccessioniPrimary (citable) accession number: Q4V8K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.