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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

Ube2l6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_348632. ISG15 antiviral mechanism.
REACT_359910. Termination of translesion DNA synthesis.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:Ube2l6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307960. Ube2l6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375221Add
BLAST

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ4V8J2.

Expressioni

Gene expression databases

GenevisibleiQ4V8J2. RN.

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039001.

Structurei

3D structure databases

ProteinModelPortaliQ4V8J2.
SMRiQ4V8J2. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiQ4V8J2.
KOiK04553.
OMAiEKPPYNL.
OrthoDBiEOG7GXPD8.
PhylomeDBiQ4V8J2.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA
60 70 80 90 100
FGLRIDFPRE YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK
110 120 130 140 150
AYQVLEALNI LVSRPNLEEP VRLELADLLT QDPEMFRKKA EEFTLQYGVD

RPS
Length:153
Mass (Da):17,807
Last modified:July 5, 2005 - v1
Checksum:i47E1AC421ADC756E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097364 mRNA. Translation: AAH97364.1.
RefSeqiNP_001019926.1. NM_001024755.1.
UniGeneiRn.8609.

Genome annotation databases

EnsembliENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467.
GeneIDi295704.
KEGGirno:295704.
UCSCiRGD:1307960. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097364 mRNA. Translation: AAH97364.1.
RefSeqiNP_001019926.1. NM_001024755.1.
UniGeneiRn.8609.

3D structure databases

ProteinModelPortaliQ4V8J2.
SMRiQ4V8J2. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039001.

Proteomic databases

PRIDEiQ4V8J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467.
GeneIDi295704.
KEGGirno:295704.
UCSCiRGD:1307960. rat.

Organism-specific databases

CTDi9246.
RGDi1307960. Ube2l6.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiQ4V8J2.
KOiK04553.
OMAiEKPPYNL.
OrthoDBiEOG7GXPD8.
PhylomeDBiQ4V8J2.
TreeFamiTF313043.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_348632. ISG15 antiviral mechanism.
REACT_359910. Termination of translesion DNA synthesis.

Miscellaneous databases

NextBioi639925.
PROiQ4V8J2.

Gene expression databases

GenevisibleiQ4V8J2. RN.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiUB2L6_RAT
AccessioniPrimary (citable) accession number: Q4V8J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 5, 2005
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.