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Q4V8J2 (UB2L6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene names
Name:Ube2l6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) By similarity.

Post-translational modification

ISGylated By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6
PRO_0000375221

Sites

Active site861Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V8J2 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 47E1AC421ADC756E

FASTA15317,807
        10         20         30         40         50         60 
MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA FGLRIDFPRE 

        70         80         90        100        110        120 
YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK AYQVLEALNI LVSRPNLEEP 

       130        140        150 
VRLELADLLT QDPEMFRKKA EEFTLQYGVD RPS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097364 mRNA. Translation: AAH97364.1.
RefSeqNP_001019926.1. NM_001024755.1.
UniGeneRn.8609.

3D structure databases

ProteinModelPortalQ4V8J2.
SMRQ4V8J2. Positions 3-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000039001.

Proteomic databases

PRIDEQ4V8J2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467.
GeneID295704.
KEGGrno:295704.
UCSCRGD:1307960. rat.

Organism-specific databases

CTD9246.
RGD1307960. Ube2l6.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00740000115416.
HOGENOMHOG000233455.
InParanoidQ4V8J2.
KOK04553.
OMAKYLESTM.
OrthoDBEOG7GXPD8.
PhylomeDBQ4V8J2.
TreeFamTF313043.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ4V8J2.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio639925.
PROQ4V8J2.

Entry information

Entry nameUB2L6_RAT
AccessionPrimary (citable) accession number: Q4V8J2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways