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Q4V8J2

- UB2L6_RAT

UniProt

Q4V8J2 - UB2L6_RAT

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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

Ube2l6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: Ensembl

GO - Biological processi

  1. ISG15-protein conjugation Source: Ensembl
  2. modification-dependent protein catabolic process Source: Ensembl
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198999. ISG15 antiviral mechanism.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:Ube2l6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1307960. Ube2l6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375221Add
BLAST

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ4V8J2.

Expressioni

Gene expression databases

GenevestigatoriQ4V8J2.

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039001.

Structurei

3D structure databases

ProteinModelPortaliQ4V8J2.
SMRiQ4V8J2. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiQ4V8J2.
KOiK04553.
OMAiKYLESTM.
OrthoDBiEOG7GXPD8.
PhylomeDBiQ4V8J2.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA
60 70 80 90 100
FGLRIDFPRE YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK
110 120 130 140 150
AYQVLEALNI LVSRPNLEEP VRLELADLLT QDPEMFRKKA EEFTLQYGVD

RPS
Length:153
Mass (Da):17,807
Last modified:July 5, 2005 - v1
Checksum:i47E1AC421ADC756E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097364 mRNA. Translation: AAH97364.1.
RefSeqiNP_001019926.1. NM_001024755.1.
UniGeneiRn.8609.

Genome annotation databases

EnsembliENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467.
GeneIDi295704.
KEGGirno:295704.
UCSCiRGD:1307960. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097364 mRNA. Translation: AAH97364.1 .
RefSeqi NP_001019926.1. NM_001024755.1.
UniGenei Rn.8609.

3D structure databases

ProteinModelPortali Q4V8J2.
SMRi Q4V8J2. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000039001.

Proteomic databases

PRIDEi Q4V8J2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000044319 ; ENSRNOP00000039001 ; ENSRNOG00000030467 .
GeneIDi 295704.
KEGGi rno:295704.
UCSCi RGD:1307960. rat.

Organism-specific databases

CTDi 9246.
RGDi 1307960. Ube2l6.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00760000119012.
HOGENOMi HOG000233455.
InParanoidi Q4V8J2.
KOi K04553.
OMAi KYLESTM.
OrthoDBi EOG7GXPD8.
PhylomeDBi Q4V8J2.
TreeFami TF313043.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_198999. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi 639925.
PROi Q4V8J2.

Gene expression databases

Genevestigatori Q4V8J2.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiUB2L6_RAT
AccessioniPrimary (citable) accession number: Q4V8J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3