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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

Ube2l6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1169408 ISG15 antiviral mechanism
R-RNO-5656169 Termination of translesion DNA synthesis
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme L6
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:Ube2l6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1307960 Ube2l6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003752211 – 153Ubiquitin/ISG15-conjugating enzyme E2 L6Add BLAST153

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ4V8J2
PRIDEiQ4V8J2

Expressioni

Gene expression databases

BgeeiENSRNOG00000030467
GenevisibleiQ4V8J2 RN

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039001

Structurei

3D structure databases

ProteinModelPortaliQ4V8J2
SMRiQ4V8J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0422 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
InParanoidiQ4V8J2
KOiK04553
OMAiSNENWKP
OrthoDBiEOG091G0QDO
PhylomeDBiQ4V8J2
TreeFamiTF313043

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V8J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA
60 70 80 90 100
FGLRIDFPRE YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK
110 120 130 140 150
AYQVLEALNI LVSRPNLEEP VRLELADLLT QDPEMFRKKA EEFTLQYGVD

RPS
Length:153
Mass (Da):17,807
Last modified:July 5, 2005 - v1
Checksum:i47E1AC421ADC756E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097364 mRNA Translation: AAH97364.1
RefSeqiNP_001019926.1, NM_001024755.1
UniGeneiRn.8609

Genome annotation databases

EnsembliENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467
GeneIDi295704
KEGGirno:295704
UCSCiRGD:1307960 rat

Similar proteinsi

Entry informationi

Entry nameiUB2L6_RAT
AccessioniPrimary (citable) accession number: Q4V8J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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