Reviewed, UniProtKB/Swiss-Prot Q4V8J2 (UB2L6_RAT)

Names and origin

Protein names

Recommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase L6
    Ubiquitin carrier protein L6
    UbcM8

Gene names

Name:

Ube2l6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	Ubiquitin/ISG15-conjugating enzyme E2 L6		PRO_0000375221
Sites
	Active site	86	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V8J2-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 47E1AC421ADC756E	FASTA	153	17,807
	10 20 30 40 50 60 MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA FGLRIDFPRE 70 80 90 100 110 120 YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK AYQVLEALNI LVSRPNLEEP 130 140 150 VRLELADLLT QDPEMFRKKA EEFTLQYGVD RPS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097364 mRNA. Translation: AAH97364.1.
IPI	IPI00372788.
RefSeq	NP_001019926.1.
UniGene	Rn.8609
3D structure databases
HSSP	HSSP built from PDB template 1WZV based on UniProtKB O14933.
SMR	Q4V8J2. Positions 3-152.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467; Rattus norvegicus. [Genome view]
GeneID	295704.
KEGG	rno:295704.
UCSC	NM_001024755. rat.
Organism-specific databases
CTD	295704.
RGD	1307960. Ube2l6.
Phylogenomic databases
eggNOG	roNOG15810.
HOVERGEN	Q4V8J2.
InParanoid	Q4V8J2.
OMA	PEKPPYN.
OrthoDB	EOG9B8MZ9.
Gene expression databases
ArrayExpress	Q4V8J2.
Genevestigator	Q4V8J2.
Family and domain databases
InterPro	IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	639925.

Entry information

Entry name

UB2L6_RAT

Accession

Primary (citable) accession number: Q4V8J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	July 5, 2005
Last modified:	January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)