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Reviewed, UniProtKB/Swiss-Prot Q4V8J2 (UB2L6_RAT)

Last modified November 3, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase L6
    Ubiquitin carrier protein L6
    UbcM8
Gene names
Name: Ube2l6
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6
PRO_0000375221

Sites

Active site861Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V8J2-1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 47E1AC421ADC756E

FASTA15317,807
        10         20         30         40         50         60 
MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA FGLRIDFPRE 

        70         80         90        100        110        120 
YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK AYQVLEALNI LVSRPNLEEP 

       130        140        150 
VRLELADLLT QDPEMFRKKA EEFTLQYGVD RPS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

BC097364 mRNA. Translation: AAH97364.1.
IPIIPI00372788.
RefSeqNP_001019926.1.
UniGeneRn.8609

3D structure databases

SMRQ4V8J2. Positions 3-152.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467; Rattus norvegicus. [Genome view]
GeneID295704.
KEGGrno:295704.
UCSCNM_001024755. rat.

Organism-specific databases

CTD295704.
RGD1307960. Ube2l6.

Phylogenomic databases

HOVERGENQ4V8J2.
OMAEFTLQFG.

Gene expression databases

ArrayExpressQ4V8J2.
GenevestigatorQ4V8J2.

Family and domain databases

InterProIPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio639925.

Entry information

Entry nameUB2L6_RAT
AccessionPrimary (citable) accession number: Q4V8J2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 5, 2005
Last modified: November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents