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Q4V8J2

- UB2L6_RAT

UniProt

Q4V8J2 - UB2L6_RAT

Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

Ube2l6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ISG15 ligase activity Source: Ensembl

    GO - Biological processi

    1. ISG15-protein conjugation Source: Ensembl
    2. modification-dependent protein catabolic process Source: Ensembl
    3. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198999. ISG15 antiviral mechanism.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein L6
    Ubiquitin-protein ligase L6
    Gene namesi
    Name:Ube2l6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1307960. Ube2l6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375221Add
    BLAST

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ4V8J2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4V8J2.

    Interactioni

    Subunit structurei

    Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000039001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V8J2.
    SMRiQ4V8J2. Positions 3-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00740000115416.
    HOGENOMiHOG000233455.
    InParanoidiQ4V8J2.
    KOiK04553.
    OMAiKYLESTM.
    OrthoDBiEOG7GXPD8.
    PhylomeDBiQ4V8J2.
    TreeFamiTF313043.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4V8J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA    50
    FGLRIDFPRE YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK 100
    AYQVLEALNI LVSRPNLEEP VRLELADLLT QDPEMFRKKA EEFTLQYGVD 150
    RPS 153
    Length:153
    Mass (Da):17,807
    Last modified:July 5, 2005 - v1
    Checksum:i47E1AC421ADC756E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097364 mRNA. Translation: AAH97364.1.
    RefSeqiNP_001019926.1. NM_001024755.1.
    UniGeneiRn.8609.

    Genome annotation databases

    EnsembliENSRNOT00000044319; ENSRNOP00000039001; ENSRNOG00000030467.
    GeneIDi295704.
    KEGGirno:295704.
    UCSCiRGD:1307960. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097364 mRNA. Translation: AAH97364.1 .
    RefSeqi NP_001019926.1. NM_001024755.1.
    UniGenei Rn.8609.

    3D structure databases

    ProteinModelPortali Q4V8J2.
    SMRi Q4V8J2. Positions 3-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000039001.

    Proteomic databases

    PRIDEi Q4V8J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000044319 ; ENSRNOP00000039001 ; ENSRNOG00000030467 .
    GeneIDi 295704.
    KEGGi rno:295704.
    UCSCi RGD:1307960. rat.

    Organism-specific databases

    CTDi 9246.
    RGDi 1307960. Ube2l6.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00740000115416.
    HOGENOMi HOG000233455.
    InParanoidi Q4V8J2.
    KOi K04553.
    OMAi KYLESTM.
    OrthoDBi EOG7GXPD8.
    PhylomeDBi Q4V8J2.
    TreeFami TF313043.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_198999. ISG15 antiviral mechanism.

    Miscellaneous databases

    NextBioi 639925.
    PROi Q4V8J2.

    Gene expression databases

    Genevestigatori Q4V8J2.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiUB2L6_RAT
    AccessioniPrimary (citable) accession number: Q4V8J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3