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Protein

Tensin-4

Gene

Tns4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Gene namesi
Name:Tns4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310402 Tns4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14By similarityAdd BLAST14
ChainiPRO_000024821515 – 718Tensin-4Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8I3
PRIDEiQ4V8I3

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029109

Structurei

3D structure databases

ProteinModelPortaliQ4V8I3
SMRiQ4V8I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini451 – 558SH2PROSITE-ProRule annotationAdd BLAST108
Domaini550 – 717Phosphatase tensin-typeAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 310Ser-richAdd BLAST119

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410KDWK Eukaryota
ENOG41125SH LUCA
HOGENOMiHOG000230981
HOVERGENiHBG080039
InParanoidiQ4V8I3
KOiK18080
PhylomeDBiQ4V8I3

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLLTGGH VVSLTPHEES RMALHPTPSH DLPALCPYYT TESWGTQPLM
60 70 80 90 100
DPTLCKGSSN RLQQAQQAEA RAQCLLQCPG EQASGASQDL DSCIDFSLEA
110 120 130 140 150
LNKMILELDP TFQLLPSGIA GPQAEPTNSV ASRTKKEEPD ALDIKYIEVT
160 170 180 190 200
STRSRCLDSP QRCSSPCVTP PFGSPRSGGL FLSRDIPRET RSSSNESLIF
210 220 230 240 250
SGNQGRGSSP HTPSSLSNSI PCRESRASGS PLATPPGWEK GLRAPQWGSR
260 270 280 290 300
VSTLSASPVS DISYVFGSNQ SLPHSSLSSY PPSSRSLGSP ASSSSSLHSL
310 320 330 340 350
DRGSQCVRSS DAQVPSNPIV GMGQPQAVPS TPVAKEQASS CPPSVTNSMA
360 370 380 390 400
DIPIVLINGN PEPQSPPAQQ TPRYQDSVQS RATSPSHLCQ ATKSHSKTLP
410 420 430 440 450
DVPLTSPSHL CQATKSHSKT LPDVPLTASP ESPAKDMQPT MKFVMDTSKY
460 470 480 490 500
WLKPSITREQ AINLLRTEKP GTFVIRDSSS YRGSFGLALK VQETPASAPN
510 520 530 540 550
RPGEDSTDFI RHFLVESSAK GVHLKGADEE PYFGSLSAFV CQHSIMALAL
560 570 580 590 600
PCKLTIPQKE LGGAEPASDS PTHGQTSCLK ISAGCHTLYL TSVSVETLSG
610 620 630 640 650
ALAVQKAISV MLERDVLPTP TVVHFKVTEQ GITLTDVQRK VFFRRHYPLI
660 670 680 690 700
ALRFCGMDPE QRKWQKYCKP SRIFGFVAKS QTEPQENACH LFAEYDAAQP
710
ASQVISLVTA LLKDTERV
Length:718
Mass (Da):77,245
Last modified:July 5, 2005 - v1
Checksum:iAD76CE54CAD8E3F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097378 mRNA Translation: AAH97378.1
RefSeqiNP_001020052.1, NM_001024881.1
UniGeneiRn.23329

Genome annotation databases

GeneIDi303517
KEGGirno:303517
UCSCiRGD:1310402 rat

Similar proteinsi

Entry informationi

Entry nameiTENS4_RAT
AccessioniPrimary (citable) accession number: Q4V8I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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