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Protein

Tensin-4

Gene

Tns4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Gene namesi
Name:Tns4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310402. Tns4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414By similarityAdd
BLAST
Chaini15 – 718704Tensin-4PRO_0000248215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei230 – 2301PhosphoserineBy similarity

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8I3.
PRIDEiQ4V8I3.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029109.

Structurei

3D structure databases

ProteinModelPortaliQ4V8I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini451 – 558108SH2PROSITE-ProRule annotationAdd
BLAST
Domaini550 – 717168Phosphatase tensin-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi192 – 310119Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410KDWK. Eukaryota.
ENOG41125SH. LUCA.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ4V8I3.
KOiK18080.
PhylomeDBiQ4V8I3.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLLTGGH VVSLTPHEES RMALHPTPSH DLPALCPYYT TESWGTQPLM
60 70 80 90 100
DPTLCKGSSN RLQQAQQAEA RAQCLLQCPG EQASGASQDL DSCIDFSLEA
110 120 130 140 150
LNKMILELDP TFQLLPSGIA GPQAEPTNSV ASRTKKEEPD ALDIKYIEVT
160 170 180 190 200
STRSRCLDSP QRCSSPCVTP PFGSPRSGGL FLSRDIPRET RSSSNESLIF
210 220 230 240 250
SGNQGRGSSP HTPSSLSNSI PCRESRASGS PLATPPGWEK GLRAPQWGSR
260 270 280 290 300
VSTLSASPVS DISYVFGSNQ SLPHSSLSSY PPSSRSLGSP ASSSSSLHSL
310 320 330 340 350
DRGSQCVRSS DAQVPSNPIV GMGQPQAVPS TPVAKEQASS CPPSVTNSMA
360 370 380 390 400
DIPIVLINGN PEPQSPPAQQ TPRYQDSVQS RATSPSHLCQ ATKSHSKTLP
410 420 430 440 450
DVPLTSPSHL CQATKSHSKT LPDVPLTASP ESPAKDMQPT MKFVMDTSKY
460 470 480 490 500
WLKPSITREQ AINLLRTEKP GTFVIRDSSS YRGSFGLALK VQETPASAPN
510 520 530 540 550
RPGEDSTDFI RHFLVESSAK GVHLKGADEE PYFGSLSAFV CQHSIMALAL
560 570 580 590 600
PCKLTIPQKE LGGAEPASDS PTHGQTSCLK ISAGCHTLYL TSVSVETLSG
610 620 630 640 650
ALAVQKAISV MLERDVLPTP TVVHFKVTEQ GITLTDVQRK VFFRRHYPLI
660 670 680 690 700
ALRFCGMDPE QRKWQKYCKP SRIFGFVAKS QTEPQENACH LFAEYDAAQP
710
ASQVISLVTA LLKDTERV
Length:718
Mass (Da):77,245
Last modified:July 5, 2005 - v1
Checksum:iAD76CE54CAD8E3F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097378 mRNA. Translation: AAH97378.1.
RefSeqiNP_001020052.1. NM_001024881.1.
UniGeneiRn.23329.

Genome annotation databases

GeneIDi303517.
KEGGirno:303517.
UCSCiRGD:1310402. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097378 mRNA. Translation: AAH97378.1.
RefSeqiNP_001020052.1. NM_001024881.1.
UniGeneiRn.23329.

3D structure databases

ProteinModelPortaliQ4V8I3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029109.

Proteomic databases

PaxDbiQ4V8I3.
PRIDEiQ4V8I3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi303517.
KEGGirno:303517.
UCSCiRGD:1310402. rat.

Organism-specific databases

CTDi84951.
RGDi1310402. Tns4.

Phylogenomic databases

eggNOGiENOG410KDWK. Eukaryota.
ENOG41125SH. LUCA.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ4V8I3.
KOiK18080.
PhylomeDBiQ4V8I3.

Miscellaneous databases

PROiQ4V8I3.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTENS4_RAT
AccessioniPrimary (citable) accession number: Q4V8I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.