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Protein

Endothelial protein C receptor

Gene

Procr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140875. Common Pathway of Fibrin Clot Formation.
R-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:Procr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1305991. Procr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 213193ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Topological domaini235 – 2417CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 241221Endothelial protein C receptorPRO_0000021193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4V8I1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019330.
GenevisibleiQ4V8I1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052129.

Structurei

3D structure databases

ProteinModelPortaliQ4V8I1.
SMRiQ4V8I1. Positions 24-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ4V8I1.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ4V8I1.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKFLSLLL LLLLLGCAFC NSDGSQSLHM LQISYFPDPY HGRHQGNASL
60 70 80 90 100
GKLLTHTLEG PSNNVTILQL QDWQDPDSWA RTESGLKIYL SQFNSLVQLI
110 120 130 140 150
YRERKNDVVF PLTVSCSVGC ELPPEEGSEP HVFFDVAVNG SAFVSFQPKT
160 170 180 190 200
AIWVTGSQEP SEAINFTLKQ LNTYNRTRYE LQEFLQDTCV QYLENHITTQ
210 220 230 240
NTKGSQTGRS YTSLVLGILM GCFIIAGVAV GIFLCTGGRR C
Length:241
Mass (Da):26,839
Last modified:July 5, 2005 - v1
Checksum:i855D39A3DE5CD6BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097380 mRNA. Translation: AAH97380.1.
BC099115 mRNA. Translation: AAH99115.1.
RefSeqiNP_001020904.1. NM_001025733.2.
UniGeneiRn.144312.

Genome annotation databases

EnsembliENSRNOT00000055254; ENSRNOP00000052129; ENSRNOG00000019330.
GeneIDi362248.
KEGGirno:362248.
UCSCiRGD:1305991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097380 mRNA. Translation: AAH97380.1.
BC099115 mRNA. Translation: AAH99115.1.
RefSeqiNP_001020904.1. NM_001025733.2.
UniGeneiRn.144312.

3D structure databases

ProteinModelPortaliQ4V8I1.
SMRiQ4V8I1. Positions 24-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052129.

Proteomic databases

PaxDbiQ4V8I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055254; ENSRNOP00000052129; ENSRNOG00000019330.
GeneIDi362248.
KEGGirno:362248.
UCSCiRGD:1305991. rat.

Organism-specific databases

CTDi10544.
RGDi1305991. Procr.

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ4V8I1.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ4V8I1.

Enzyme and pathway databases

ReactomeiR-RNO-140875. Common Pathway of Fibrin Clot Formation.
R-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiQ4V8I1.

Gene expression databases

BgeeiENSRNOG00000019330.
GenevisibleiQ4V8I1. RN.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPCR_RAT
AccessioniPrimary (citable) accession number: Q4V8I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.