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Protein

Endothelial protein C receptor

Gene

Procr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:Procr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1305991 Procr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 213ExtracellularSequence analysisAdd BLAST193
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 241CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002119321 – 241Endothelial protein C receptorAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4V8I1

Expressioni

Gene expression databases

BgeeiENSRNOG00000019330
GenevisibleiQ4V8I1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052129

Structurei

3D structure databases

ProteinModelPortaliQ4V8I1
SMRiQ4V8I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ4V8I1
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
PhylomeDBiQ4V8I1

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKFLSLLL LLLLLGCAFC NSDGSQSLHM LQISYFPDPY HGRHQGNASL
60 70 80 90 100
GKLLTHTLEG PSNNVTILQL QDWQDPDSWA RTESGLKIYL SQFNSLVQLI
110 120 130 140 150
YRERKNDVVF PLTVSCSVGC ELPPEEGSEP HVFFDVAVNG SAFVSFQPKT
160 170 180 190 200
AIWVTGSQEP SEAINFTLKQ LNTYNRTRYE LQEFLQDTCV QYLENHITTQ
210 220 230 240
NTKGSQTGRS YTSLVLGILM GCFIIAGVAV GIFLCTGGRR C
Length:241
Mass (Da):26,839
Last modified:July 5, 2005 - v1
Checksum:i855D39A3DE5CD6BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097380 mRNA Translation: AAH97380.1
BC099115 mRNA Translation: AAH99115.1
RefSeqiNP_001020904.1, NM_001025733.2
UniGeneiRn.144312

Genome annotation databases

EnsembliENSRNOT00000055254; ENSRNOP00000052129; ENSRNOG00000019330
GeneIDi362248
KEGGirno:362248
UCSCiRGD:1305991 rat

Entry informationi

Entry nameiEPCR_RAT
AccessioniPrimary (citable) accession number: Q4V8I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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