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Protein

Septin-12

Gene

Sept12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87GTPBy similarity1
Binding sitei113GTP; via amide nitrogenBy similarity1
Binding sitei249GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei264GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 61GTPBy similarity8
Nucleotide bindingi193 – 201GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-12
Gene namesi
Name:Sept12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1565511. Sept12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61S → N: Abolishes homodimerization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128611 – 356Septin-12Add BLAST356

Proteomic databases

PaxDbiQ4V8G5.
PRIDEiQ4V8G5.

Expressioni

Tissue specificityi

Predominantly expressed in testis and epididymis. Component of the sperm tail annulus (at protein level).1 Publication

Developmental stagei

In developing testis, expression increases steadily until sexual maturity (approximately 49 days postpartum) where it remains expressed at a relatively constant level.1 Publication

Gene expression databases

BgeeiENSRNOG00000003137.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT6 and SEPT11. Forms homodimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ4V8G5. 1 interactor.
STRINGi10116.ENSRNOP00000057921.

Structurei

3D structure databases

ProteinModelPortaliQ4V8G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 315Septin-type GAdd BLAST272

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ4V8G5.
KOiK16938.
OMAiEMLGYVG.
OrthoDBiEOG091G08V5.
PhylomeDBiQ4V8G5.
TreeFamiTF101078.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERRTPSPC SSRPSSPRTP PCEMFGPVGI EAVLDQLRIK AMKTGFEFNI
60 70 80 90 100
MVVGQSGLGK STMVNTLFKS KVWQSPAPNL DVPMPQTLEL HSVTHVIEEK
110 120 130 140 150
GLKLKLTVTD TPGFGDQINN DKCWDPILSY INQQYEQYLQ EELLITRQRH
160 170 180 190 200
IPDTRVHCCV YFVPPTGHCL RPLDIEFLRR LCRTVNVVPV IARADSLTIE
210 220 230 240 250
ERDAFRSRIQ QNLKNHCIDV YPQQCFDEDI NDRLLNSKIR EQIPFAVVGA
260 270 280 290 300
DREHIVNGRC VLGRKTKWGI IEVENMAHCE FLLLRDLLIR SHLQDLKDIT
310 320 330 340 350
HNVHYENYRV LRLNESHVLP RGPGWVNLAP ASPGQLMAPG PEKVRKRSKD

PRDDEC
Length:356
Mass (Da):40,799
Last modified:December 4, 2007 - v2
Checksum:i598F80BE45A1F451
GO

Sequence cautioni

The sequence AAH97401 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097401 mRNA. Translation: AAH97401.1. Different initiation.
RefSeqiNP_001094335.1. NM_001100865.1.
UniGeneiRn.123511.

Genome annotation databases

EnsembliENSRNOT00000061208; ENSRNOP00000057921; ENSRNOG00000003137.
GeneIDi363542.
KEGGirno:363542.
UCSCiRGD:1565511. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097401 mRNA. Translation: AAH97401.1. Different initiation.
RefSeqiNP_001094335.1. NM_001100865.1.
UniGeneiRn.123511.

3D structure databases

ProteinModelPortaliQ4V8G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4V8G5. 1 interactor.
STRINGi10116.ENSRNOP00000057921.

Proteomic databases

PaxDbiQ4V8G5.
PRIDEiQ4V8G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061208; ENSRNOP00000057921; ENSRNOG00000003137.
GeneIDi363542.
KEGGirno:363542.
UCSCiRGD:1565511. rat.

Organism-specific databases

CTDi124404.
RGDi1565511. Sept12.

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ4V8G5.
KOiK16938.
OMAiEMLGYVG.
OrthoDBiEOG091G08V5.
PhylomeDBiQ4V8G5.
TreeFamiTF101078.

Miscellaneous databases

PROiQ4V8G5.

Gene expression databases

BgeeiENSRNOG00000003137.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEP12_RAT
AccessioniPrimary (citable) accession number: Q4V8G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.