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Protein

Hydroxysteroid dehydrogenase-like protein 2

Gene

Hsdl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has apparently no steroid dehydrogenase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421NADPBy similarity
Binding sitei74 – 741NADPBy similarity
Active sitei168 – 1681Proton acceptorSequence analysis
Binding sitei172 – 1721NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 237NADPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid dehydrogenase-like protein 2 (EC:1.-.-.-)
Gene namesi
Name:Hsdl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305387. Hsdl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Hydroxysteroid dehydrogenase-like protein 2PRO_0000319891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysineBy similarity
Modified residuei424 – 4241N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4V8F9.
PRIDEiQ4V8F9.

PTM databases

iPTMnetiQ4V8F9.
PhosphoSiteiQ4V8F9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016692.
GenevisibleiQ4V8F9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056213.

Structurei

3D structure databases

ProteinModelPortaliQ4V8F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini414 – 521108SCP2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi300 – 404105Gln/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 SCP2 domain.Curated

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ4V8F9.
OMAiARGTYMC.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ4V8F9.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPNTGKLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTTQRHPKL
60 70 80 90 100
LGTIYTAAEE IEAAGGKALP CVVDVRDEQQ INSAVEKAVE RFGGIDILVN
110 120 130 140 150
NASAISLTNT LETPTKRVDL MMSVNTRGTY LTSKACIPFL KKSKVAHILN
160 170 180 190 200
LSPPLNLNPM WFKQHCAYTI AKYGMSMCVL GMAEEFRGEI AVNALWPRTA
210 220 230 240 250
IHTAAMDMLG GAGVESQCRK VDIIADAAYS IFKRPKSFTG NFIIDENILK
260 270 280 290 300
EEGIKDFDIY AITPGHPLLP DFFLDEHPDA VMEEKESYDP VPEVKEEKLQ
310 320 330 340 350
LQEQPQLQEQ PQLQEKPQLQ EQPQLQEKPQ LQEQPQLQEQ PQLQEQPQQQ
360 370 380 390 400
PQLQEQPQLQ EKPQLQEQPQ QQEKPQPQQQ PQQQPQQRPQ QRPQPQPQPQ
410 420 430 440 450
PLLQSVLPPK PHFGAVEETF RIVKDSLSDE VVRATQAVYQ FELSGEDGGT
460 470 480 490 500
WFLDLKSKGG KVGHGEPSDR ADVVMSMATE DFVKMFSGKL KPTMAFMSGK
510 520
LKIKGNIALA IKLEKLMTHM NSRL
Length:524
Mass (Da):58,344
Last modified:July 5, 2005 - v1
Checksum:i1A8C5149397F5A4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097407 mRNA. Translation: AAH97407.1.
RefSeqiNP_001020868.1. NM_001025697.1.
UniGeneiRn.203684.

Genome annotation databases

EnsembliENSRNOT00000059458; ENSRNOP00000056213; ENSRNOG00000016692.
GeneIDi313200.
KEGGirno:313200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097407 mRNA. Translation: AAH97407.1.
RefSeqiNP_001020868.1. NM_001025697.1.
UniGeneiRn.203684.

3D structure databases

ProteinModelPortaliQ4V8F9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056213.

PTM databases

iPTMnetiQ4V8F9.
PhosphoSiteiQ4V8F9.

Proteomic databases

PaxDbiQ4V8F9.
PRIDEiQ4V8F9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059458; ENSRNOP00000056213; ENSRNOG00000016692.
GeneIDi313200.
KEGGirno:313200.

Organism-specific databases

CTDi84263.
RGDi1305387. Hsdl2.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
KOG4170. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00730000111071.
HOVERGENiHBG107982.
InParanoidiQ4V8F9.
OMAiARGTYMC.
OrthoDBiEOG091G0EVM.
PhylomeDBiQ4V8F9.

Miscellaneous databases

PROiQ4V8F9.

Gene expression databases

BgeeiENSRNOG00000016692.
GenevisibleiQ4V8F9. RN.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF55718. SSF55718. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSDL2_RAT
AccessioniPrimary (citable) accession number: Q4V8F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.