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Q4V8E6 (GSTT4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase theta-4

EC=2.5.1.18
Alternative name(s):
GST class-theta-4
Gene names
Name:Gstt4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Glutathione S-transferase theta-4
PRO_0000329077

Regions

Domain1 – 8282GST N-terminal
Domain88 – 218131GST C-terminal
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site401Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V8E6 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 2D4B938412854822

FASTA24027,970
        10         20         30         40         50         60 
MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP LRKVPSLRDG 

        70         80         90        100        110        120 
KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA WQHTAIQVPM SKILWIKLII 

       130        140        150        160        170        180 
PMITGEEVPT ERLDKTLDEV NKNIKQFEEK FLQDKLFITG DHISLADLVA LVEMMQPMGT 

       190        200        210        220        230        240 
NHNVFISSKL AEWRMRVELA IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097423 mRNA. Translation: AAH97423.1.
RefSeqNP_001103145.1. NM_001109675.1.
UniGeneRn.190813.

3D structure databases

ProteinModelPortalQ4V8E6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000055115.

PTM databases

PhosphoSiteQ4V8E6.

Proteomic databases

PRIDEQ4V8E6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneID686922.
KEGGrno:686922.
UCSCRGD:1591294. rat.

Organism-specific databases

CTD75886.
RGD1591294. Gstt4.

Phylogenomic databases

eggNOGCOG0625.
GeneTreeENSGT00540000069741.
HOVERGENHBG051854.
OMAPMITGEE.
OrthoDBEOG7GTT59.
PhylomeDBQ4V8E6.

Gene expression databases

GenevestigatorQ4V8E6.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio733004.

Entry information

Entry nameGSTT4_RAT
AccessionPrimary (citable) accession number: Q4V8E6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families