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Protein

Glutathione S-transferase theta-4

Gene

Gstt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-4
Gene namesi
Name:Gstt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1591294. Gstt4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290771 – 240Glutathione S-transferase theta-4Add BLAST240

Proteomic databases

PaxDbiQ4V8E6.
PRIDEiQ4V8E6.

PTM databases

iPTMnetiQ4V8E6.
PhosphoSitePlusiQ4V8E6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038300.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055115.

Structurei

3D structure databases

ProteinModelPortaliQ4V8E6.
SMRiQ4V8E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82GST N-terminalAdd BLAST82
Domaini88 – 218GST C-terminalAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
HOVERGENiHBG051854.
InParanoidiQ4V8E6.
OMAiCEIDQPK.
OrthoDBiEOG091G0PCG.
PhylomeDBiQ4V8E6.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP
60 70 80 90 100
LRKVPSLRDG KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA
110 120 130 140 150
WQHTAIQVPM SKILWIKLII PMITGEEVPT ERLDKTLDEV NKNIKQFEEK
160 170 180 190 200
FLQDKLFITG DHISLADLVA LVEMMQPMGT NHNVFISSKL AEWRMRVELA
210 220 230 240
IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK
Length:240
Mass (Da):27,970
Last modified:July 5, 2005 - v1
Checksum:i2D4B938412854822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097423 mRNA. Translation: AAH97423.1.
RefSeqiNP_001103145.1. NM_001109675.1.
UniGeneiRn.190813.

Genome annotation databases

EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneIDi686922.
KEGGirno:686922.
UCSCiRGD:1591294. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGSTT4_RAT
AccessioniPrimary (citable) accession number: Q4V8E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2005
Last modified: July 5, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families