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Protein

Glutathione S-transferase theta-4

Gene

Gstt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-4
Gene namesi
Name:Gstt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1591294. Gstt4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Glutathione S-transferase theta-4PRO_0000329077Add
BLAST

Proteomic databases

PRIDEiQ4V8E6.

PTM databases

PhosphoSiteiQ4V8E6.

Expressioni

Gene expression databases

GenevestigatoriQ4V8E6.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055115.

Structurei

3D structure databases

ProteinModelPortaliQ4V8E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282GST N-terminalAdd
BLAST
Domaini88 – 218131GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOVERGENiHBG051854.
InParanoidiQ4V8E6.
OMAiEFRDNVN.
OrthoDBiEOG7GTT59.
PhylomeDBiQ4V8E6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP
60 70 80 90 100
LRKVPSLRDG KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA
110 120 130 140 150
WQHTAIQVPM SKILWIKLII PMITGEEVPT ERLDKTLDEV NKNIKQFEEK
160 170 180 190 200
FLQDKLFITG DHISLADLVA LVEMMQPMGT NHNVFISSKL AEWRMRVELA
210 220 230 240
IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK
Length:240
Mass (Da):27,970
Last modified:July 4, 2005 - v1
Checksum:i2D4B938412854822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097423 mRNA. Translation: AAH97423.1.
RefSeqiNP_001103145.1. NM_001109675.1.
UniGeneiRn.190813.

Genome annotation databases

EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneIDi686922.
KEGGirno:686922.
UCSCiRGD:1591294. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097423 mRNA. Translation: AAH97423.1.
RefSeqiNP_001103145.1. NM_001109675.1.
UniGeneiRn.190813.

3D structure databases

ProteinModelPortaliQ4V8E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055115.

PTM databases

PhosphoSiteiQ4V8E6.

Proteomic databases

PRIDEiQ4V8E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneIDi686922.
KEGGirno:686922.
UCSCiRGD:1591294. rat.

Organism-specific databases

CTDi75886.
RGDi1591294. Gstt4.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOVERGENiHBG051854.
InParanoidiQ4V8E6.
OMAiEFRDNVN.
OrthoDBiEOG7GTT59.
PhylomeDBiQ4V8E6.

Miscellaneous databases

NextBioi733004.

Gene expression databases

GenevestigatoriQ4V8E6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGSTT4_RAT
AccessioniPrimary (citable) accession number: Q4V8E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 7, 2008
Last sequence update: July 4, 2005
Last modified: January 6, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.