Q4V8E6 (GSTT4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase theta-4
EC=2.5.1.18

Alternative name(s):
GST class-theta-4

Gene names

Name:

Gstt4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Theta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Glutathione S-transferase theta-4		PRO_0000329077
Regions
	Domain	1 – 82	82	GST N-terminal
	Domain	88 – 218	131	GST C-terminal
	Region	53 – 54	2	Glutathione binding By similarity
	Region	66 – 67	2	Glutathione binding By similarity
Sites
	Binding site	40	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V8E6 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 2D4B938412854822	FASTA	240	27,970
	10 20 30 40 50 60 MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP LRKVPSLRDG 70 80 90 100 110 120 KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA WQHTAIQVPM SKILWIKLII 130 140 150 160 170 180 PMITGEEVPT ERLDKTLDEV NKNIKQFEEK FLQDKLFITG DHISLADLVA LVEMMQPMGT 190 200 210 220 230 240 NHNVFISSKL AEWRMRVELA IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097423 mRNA. Translation: AAH97423.1.
IPI	IPI00608147.
RefSeq	NP_001103145.1. NM_001109675.1.
UniGene	Rn.190813.
3D structure databases
ProteinModelPortal	Q4V8E6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000055115.
PTM databases
PhosphoSite	Q4V8E6.
Proteomic databases
PRIDE	Q4V8E6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneID	686922.
KEGG	rno:686922.
UCSC	RGD:1591294. rat.
Organism-specific databases
CTD	75886.
RGD	1591294. Gstt4.
Phylogenomic databases
eggNOG	COG0625.
GeneTree	ENSGT00540000069741.
HOVERGEN	HBG051854.
Gene expression databases
Genevestigator	Q4V8E6.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	733004.

Entry information

Entry name

GSTT4_RAT

Accession

Primary (citable) accession number: Q4V8E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 5, 2005
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program