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Q4V8E6

- GSTT4_RAT

UniProt

Q4V8E6 - GSTT4_RAT

Protein

Glutathione S-transferase theta-4

Gene

Gstt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase theta-4 (EC:2.5.1.18)
    Alternative name(s):
    GST class-theta-4
    Gene namesi
    Name:Gstt4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1591294. Gstt4.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Glutathione S-transferase theta-4PRO_0000329077Add
    BLAST

    Proteomic databases

    PRIDEiQ4V8E6.

    PTM databases

    PhosphoSiteiQ4V8E6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4V8E6.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000055115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V8E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282GST N-terminalAdd
    BLAST
    Domaini88 – 218131GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Glutathione bindingBy similarity
    Regioni66 – 672Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00540000069741.
    HOVERGENiHBG051854.
    OMAiPMITGEE.
    OrthoDBiEOG7GTT59.
    PhylomeDBiQ4V8E6.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4V8E6-1 [UniParc]FASTAAdd to Basket

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    MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP    50
    LRKVPSLRDG KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA 100
    WQHTAIQVPM SKILWIKLII PMITGEEVPT ERLDKTLDEV NKNIKQFEEK 150
    FLQDKLFITG DHISLADLVA LVEMMQPMGT NHNVFISSKL AEWRMRVELA 200
    IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK 240
    Length:240
    Mass (Da):27,970
    Last modified:July 5, 2005 - v1
    Checksum:i2D4B938412854822
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097423 mRNA. Translation: AAH97423.1.
    RefSeqiNP_001103145.1. NM_001109675.1.
    UniGeneiRn.190813.

    Genome annotation databases

    EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
    GeneIDi686922.
    KEGGirno:686922.
    UCSCiRGD:1591294. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097423 mRNA. Translation: AAH97423.1 .
    RefSeqi NP_001103145.1. NM_001109675.1.
    UniGenei Rn.190813.

    3D structure databases

    ProteinModelPortali Q4V8E6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000055115.

    PTM databases

    PhosphoSitei Q4V8E6.

    Proteomic databases

    PRIDEi Q4V8E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000058314 ; ENSRNOP00000055115 ; ENSRNOG00000038300 .
    GeneIDi 686922.
    KEGGi rno:686922.
    UCSCi RGD:1591294. rat.

    Organism-specific databases

    CTDi 75886.
    RGDi 1591294. Gstt4.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00540000069741.
    HOVERGENi HBG051854.
    OMAi PMITGEE.
    OrthoDBi EOG7GTT59.
    PhylomeDBi Q4V8E6.

    Miscellaneous databases

    NextBioi 733004.

    Gene expression databases

    Genevestigatori Q4V8E6.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiGSTT4_RAT
    AccessioniPrimary (citable) accession number: Q4V8E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3