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Q4V8E6

- GSTT4_RAT

UniProt

Q4V8E6 - GSTT4_RAT

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Protein

Glutathione S-transferase theta-4

Gene
Gstt4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-4
Gene namesi
Name:Gstt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1591294. Gstt4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Glutathione S-transferase theta-4PRO_0000329077Add
BLAST

Proteomic databases

PRIDEiQ4V8E6.

PTM databases

PhosphoSiteiQ4V8E6.

Expressioni

Gene expression databases

GenevestigatoriQ4V8E6.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055115.

Structurei

3D structure databases

ProteinModelPortaliQ4V8E6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282GST N-terminalAdd
BLAST
Domaini88 – 218131GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Glutathione binding By similarity
Regioni66 – 672Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00540000069741.
HOVERGENiHBG051854.
OMAiPMITGEE.
OrthoDBiEOG7GTT59.
PhylomeDBiQ4V8E6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8E6-1 [UniParc]FASTAAdd to Basket

« Hide

MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP    50
LRKVPSLRDG KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA 100
WQHTAIQVPM SKILWIKLII PMITGEEVPT ERLDKTLDEV NKNIKQFEEK 150
FLQDKLFITG DHISLADLVA LVEMMQPMGT NHNVFISSKL AEWRMRVELA 200
IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK 240
Length:240
Mass (Da):27,970
Last modified:July 5, 2005 - v1
Checksum:i2D4B938412854822
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097423 mRNA. Translation: AAH97423.1.
RefSeqiNP_001103145.1. NM_001109675.1.
UniGeneiRn.190813.

Genome annotation databases

EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300.
GeneIDi686922.
KEGGirno:686922.
UCSCiRGD:1591294. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097423 mRNA. Translation: AAH97423.1 .
RefSeqi NP_001103145.1. NM_001109675.1.
UniGenei Rn.190813.

3D structure databases

ProteinModelPortali Q4V8E6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000055115.

PTM databases

PhosphoSitei Q4V8E6.

Proteomic databases

PRIDEi Q4V8E6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000058314 ; ENSRNOP00000055115 ; ENSRNOG00000038300 .
GeneIDi 686922.
KEGGi rno:686922.
UCSCi RGD:1591294. rat.

Organism-specific databases

CTDi 75886.
RGDi 1591294. Gstt4.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00540000069741.
HOVERGENi HBG051854.
OMAi PMITGEE.
OrthoDBi EOG7GTT59.
PhylomeDBi Q4V8E6.

Miscellaneous databases

NextBioi 733004.

Gene expression databases

Genevestigatori Q4V8E6.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGSTT4_RAT
AccessioniPrimary (citable) accession number: Q4V8E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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