Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase theta-4

Gene

Gstt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-4
Gene namesi
Name:Gstt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1591294 Gstt4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290771 – 240Glutathione S-transferase theta-4Add BLAST240

Proteomic databases

PaxDbiQ4V8E6
PRIDEiQ4V8E6

PTM databases

iPTMnetiQ4V8E6
PhosphoSitePlusiQ4V8E6

Expressioni

Gene expression databases

BgeeiENSRNOG00000038300

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055115

Structurei

3D structure databases

ProteinModelPortaliQ4V8E6
SMRiQ4V8E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82GST N-terminalAdd BLAST82
Domaini88 – 218GST C-terminalAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
HOVERGENiHBG051854
InParanoidiQ4V8E6
KOiK00799
OMAiCEIDQPK
OrthoDBiEOG091G0PCG
PhylomeDBiQ4V8E6

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V8E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYMDLL SAPCRAVYIF ARKNGIPFDF QFVDLLKGHH HSKEYIEINP
60 70 80 90 100
LRKVPSLRDG KFILSESVAI LCYLCRKYSA PSHWYPPDLH MRARVDEFMA
110 120 130 140 150
WQHTAIQVPM SKILWIKLII PMITGEEVPT ERLDKTLDEV NKNIKQFEEK
160 170 180 190 200
FLQDKLFITG DHISLADLVA LVEMMQPMGT NHNVFISSKL AEWRMRVELA
210 220 230 240
IGSGLFWEAH DRLVKLPSWD CSTLDPSIKM KICEFLQKYK
Length:240
Mass (Da):27,970
Last modified:July 5, 2005 - v1
Checksum:i2D4B938412854822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097423 mRNA Translation: AAH97423.1
RefSeqiNP_001103145.1, NM_001109675.1
UniGeneiRn.190813

Genome annotation databases

EnsembliENSRNOT00000058314; ENSRNOP00000055115; ENSRNOG00000038300
GeneIDi686922
KEGGirno:686922
UCSCiRGD:1591294 rat

Similar proteinsi

Entry informationi

Entry nameiGSTT4_RAT
AccessioniPrimary (citable) accession number: Q4V8E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health