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Protein

Major facilitator superfamily domain-containing protein 3

Gene

Mfsd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.25.4. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 3
Gene namesi
Name:Mfsd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560274. Mfsd3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei139 – 158HelicalSequence analysisAdd BLAST20
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733941 – 416Major facilitator superfamily domain-containing protein 3Add BLAST416

Proteomic databases

PaxDbiQ4V8E5.
PRIDEiQ4V8E5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015685.
GenevisibleiQ4V8E5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021208.

Structurei

3D structure databases

ProteinModelPortaliQ4V8E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 410Leu-richAdd BLAST406
Compositional biasi5 – 406Leu-richAdd BLAST402

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ4V8E5.
OMAiFPLWRIT.
OrthoDBiEOG091G0JAA.
PhylomeDBiQ4V8E5.
TreeFamiTF330933.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGKLLPLAG LYLVQGLPYG LQSSLLPILL RARGLSLTRV GLTKGLYAPW
60 70 80 90 100
LLKLAWAPLV DRRGTPRVWL TFSTVCLGLV CGLLAVLPPP QAGQTGLPTT
110 120 130 140 150
VMGLLLLLNL GAAVQDVALD TLAVQLLEPK ELGPGNTVQV VAYKLGSALA
160 170 180 190 200
GGGLLVFFPT LSWPLLFLLL TATYWLAAAL AWAAPALGRL SRPQVSEHTP
210 220 230 240 250
HTSYLLQDLL AVPGTLWTAG FVLTYKMGEQ GAGSLFPLLL LDHGASASDL
260 270 280 290 300
GLWSGLGAAT CSIAGSSLGG ALLARHCSHP RQPLKLLRSV LQLRLGGLAC
310 320 330 340 350
QTALLLHLNT PGASLDPGTV MRGAALLSLC LQQFLGGVVT TATFTVMMHC
360 370 380 390 400
SQLAPRALQA THYSFLATLE LLGKLLPGTL AGVLADGLGP RLCFAAFLVL
410
SALPVLDLRL APSNLT
Length:416
Mass (Da):43,513
Last modified:July 5, 2005 - v1
Checksum:iCA7B0F3C4A3FDE4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097424 mRNA. Translation: AAH97424.1.
RefSeqiNP_001020079.1. NM_001024908.1.
UniGeneiRn.86351.

Genome annotation databases

EnsembliENSRNOT00000021208; ENSRNOP00000021208; ENSRNOG00000015685.
GeneIDi500899.
KEGGirno:500899.
UCSCiRGD:1560274. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097424 mRNA. Translation: AAH97424.1.
RefSeqiNP_001020079.1. NM_001024908.1.
UniGeneiRn.86351.

3D structure databases

ProteinModelPortaliQ4V8E5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021208.

Protein family/group databases

TCDBi2.A.1.25.4. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ4V8E5.
PRIDEiQ4V8E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021208; ENSRNOP00000021208; ENSRNOG00000015685.
GeneIDi500899.
KEGGirno:500899.
UCSCiRGD:1560274. rat.

Organism-specific databases

CTDi113655.
RGDi1560274. Mfsd3.

Phylogenomic databases

eggNOGiKOG3574. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00730000111292.
HOGENOMiHOG000217208.
HOVERGENiHBG080578.
InParanoidiQ4V8E5.
OMAiFPLWRIT.
OrthoDBiEOG091G0JAA.
PhylomeDBiQ4V8E5.
TreeFamiTF330933.

Miscellaneous databases

PROiQ4V8E5.

Gene expression databases

BgeeiENSRNOG00000015685.
GenevisibleiQ4V8E5. RN.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMFSD3_RAT
AccessioniPrimary (citable) accession number: Q4V8E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.