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Q4V8D1 (CP2U1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2U1

EC=1.14.14.1
Gene names
Name:Cyp2u1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane Ref.2.

Tissue specificity

Specifically expressed in thymus and brain. In brain, expressed in cortex, cerebellum, olfactory bulbs, pons and medulla and the limbic structures (at protein level). Ref.2

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Cytochrome P450 2U1
PRO_0000291758

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane328 – 34821Helical; Potential
Transmembrane481 – 50121Helical; Potential

Sites

Metal binding4761Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V8D1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 7BDF8BD34265801A

FASTA53060,399
        10         20         30         40         50         60 
MSSIGGLRPA AGEQPGVGPH LQAVGGALLL CGLAVLLDWV WLQRQRAGGI PPGPKPRPLV 

        70         80         90        100        110        120 
GNFGYLLLPR FLRLHFWLGS GSQTDTVGRH VYLARLARVY GNIFSFFIGH RLVVVLSDFQ 

       130        140        150        160        170        180 
SVREALVQQA EVFSDRPRMP LISILTKEKG IVFAHYGPIW KQQRRFSHST LRHFGLGKLS 

       190        200        210        220        230        240 
LEPRIIEEFA YVKAEMQKHG EAPFSPFPVI SNAVSNIICS LCFGQRFDYT NKEFKKVLDF 

       250        260        270        280        290        300 
MSRGLEICLH SQLFLINLCP WFYYLPFGPF KELRQIERDI TCFLKNIIKE HQESLDANNP 

       310        320        330        340        350        360 
QDFIDMYLLH TQEEKDKCKG TNFDEDYLFY IIGDLFIAGT DTTTNSLLWC LLYMSLNPGV 

       370        380        390        400        410        420 
QKKVHEEIER VIGRDRAPSL TDKAQMPYTE ATIMEVQRLS MVVPLAIPHM TSEKTVLQGY 

       430        440        450        460        470        480 
SIPKGTVVLP NLWSIHRDPV IWEKPDDFCP HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ 

       490        500        510        520        530 
LAKMELFLMF VSLMQSFTFA LPEGSEKPIM TGRFGLTLAP HPFNVTVSKR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1."
Karlgren M., Backlund M., Johansson I., Oscarson M., Ingelman-Sundberg M.
Biochem. Biophys. Res. Commun. 315:679-685(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097442 mRNA. Translation: AAH97442.1.
RefSeqNP_001019950.1. NM_001024779.1.
XP_006233372.1. XM_006233310.1.
UniGeneRn.161862.

3D structure databases

ProteinModelPortalQ4V8D1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000052433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055570; ENSRNOP00000052433; ENSRNOG00000011053.
GeneID310848.
KEGGrno:310848.

Organism-specific databases

CTD113612.
RGD1309433. Cyp2u1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ4V8D1.
KOK07422.
OMAIEEFAYV.
OrthoDBEOG7RBZ85.
PhylomeDBQ4V8D1.
TreeFamTF352043.

Gene expression databases

GenevestigatorQ4V8D1.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio662741.
PROQ4V8D1.

Entry information

Entry nameCP2U1_RAT
AccessionPrimary (citable) accession number: Q4V8D1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families