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Q4V8D1

- CP2U1_RAT

UniProt

Q4V8D1 - CP2U1_RAT

Protein

Cytochrome P450 2U1

Gene

Cyp2u1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi476 – 4761Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    ReactomeiREACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2U1 (EC:1.14.14.1)
    Gene namesi
    Name:Cyp2u1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1309433. Cyp2u1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Microsome membrane 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Cytochrome P450 2U1PRO_0000291758Add
    BLAST

    Expressioni

    Tissue specificityi

    Specifically expressed in thymus and brain. In brain, expressed in cortex, cerebellum, olfactory bulbs, pons and medulla and the limbic structures (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriQ4V8D1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V8D1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ4V8D1.
    KOiK07422.
    OMAiIEEFAYV.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ4V8D1.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4V8D1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIGGLRPA AGEQPGVGPH LQAVGGALLL CGLAVLLDWV WLQRQRAGGI    50
    PPGPKPRPLV GNFGYLLLPR FLRLHFWLGS GSQTDTVGRH VYLARLARVY 100
    GNIFSFFIGH RLVVVLSDFQ SVREALVQQA EVFSDRPRMP LISILTKEKG 150
    IVFAHYGPIW KQQRRFSHST LRHFGLGKLS LEPRIIEEFA YVKAEMQKHG 200
    EAPFSPFPVI SNAVSNIICS LCFGQRFDYT NKEFKKVLDF MSRGLEICLH 250
    SQLFLINLCP WFYYLPFGPF KELRQIERDI TCFLKNIIKE HQESLDANNP 300
    QDFIDMYLLH TQEEKDKCKG TNFDEDYLFY IIGDLFIAGT DTTTNSLLWC 350
    LLYMSLNPGV QKKVHEEIER VIGRDRAPSL TDKAQMPYTE ATIMEVQRLS 400
    MVVPLAIPHM TSEKTVLQGY SIPKGTVVLP NLWSIHRDPV IWEKPDDFCP 450
    HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ LAKMELFLMF VSLMQSFTFA 500
    LPEGSEKPIM TGRFGLTLAP HPFNVTVSKR 530
    Length:530
    Mass (Da):60,399
    Last modified:July 5, 2005 - v1
    Checksum:i7BDF8BD34265801A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097442 mRNA. Translation: AAH97442.1.
    RefSeqiNP_001019950.1. NM_001024779.1.
    XP_006233372.1. XM_006233310.1.
    UniGeneiRn.161862.

    Genome annotation databases

    EnsembliENSRNOT00000055570; ENSRNOP00000052433; ENSRNOG00000011053.
    GeneIDi310848.
    KEGGirno:310848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097442 mRNA. Translation: AAH97442.1 .
    RefSeqi NP_001019950.1. NM_001024779.1.
    XP_006233372.1. XM_006233310.1.
    UniGenei Rn.161862.

    3D structure databases

    ProteinModelPortali Q4V8D1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052433.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055570 ; ENSRNOP00000052433 ; ENSRNOG00000011053 .
    GeneIDi 310848.
    KEGGi rno:310848.

    Organism-specific databases

    CTDi 113612.
    RGDi 1309433. Cyp2u1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q4V8D1.
    KOi K07422.
    OMAi IEEFAYV.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q4V8D1.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    NextBioi 662741.
    PROi Q4V8D1.

    Gene expression databases

    Genevestigatori Q4V8D1.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1."
      Karlgren M., Backlund M., Johansson I., Oscarson M., Ingelman-Sundberg M.
      Biochem. Biophys. Res. Commun. 315:679-685(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCP2U1_RAT
    AccessioniPrimary (citable) accession number: Q4V8D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3