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Q4V8D1

- CP2U1_RAT

UniProt

Q4V8D1 - CP2U1_RAT

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Protein

Cytochrome P450 2U1

Gene

Cyp2u1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi476 – 4761Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2U1 (EC:1.14.14.1)
Gene namesi
Name:Cyp2u1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1309433. Cyp2u1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Microsome membrane 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome P450 2U1PRO_0000291758Add
BLAST

Expressioni

Tissue specificityi

Specifically expressed in thymus and brain. In brain, expressed in cortex, cerebellum, olfactory bulbs, pons and medulla and the limbic structures (at protein level).1 Publication

Gene expression databases

GenevestigatoriQ4V8D1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052433.

Structurei

3D structure databases

ProteinModelPortaliQ4V8D1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ4V8D1.
KOiK07422.
OMAiIEEFAYV.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ4V8D1.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8D1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSIGGLRPA AGEQPGVGPH LQAVGGALLL CGLAVLLDWV WLQRQRAGGI
60 70 80 90 100
PPGPKPRPLV GNFGYLLLPR FLRLHFWLGS GSQTDTVGRH VYLARLARVY
110 120 130 140 150
GNIFSFFIGH RLVVVLSDFQ SVREALVQQA EVFSDRPRMP LISILTKEKG
160 170 180 190 200
IVFAHYGPIW KQQRRFSHST LRHFGLGKLS LEPRIIEEFA YVKAEMQKHG
210 220 230 240 250
EAPFSPFPVI SNAVSNIICS LCFGQRFDYT NKEFKKVLDF MSRGLEICLH
260 270 280 290 300
SQLFLINLCP WFYYLPFGPF KELRQIERDI TCFLKNIIKE HQESLDANNP
310 320 330 340 350
QDFIDMYLLH TQEEKDKCKG TNFDEDYLFY IIGDLFIAGT DTTTNSLLWC
360 370 380 390 400
LLYMSLNPGV QKKVHEEIER VIGRDRAPSL TDKAQMPYTE ATIMEVQRLS
410 420 430 440 450
MVVPLAIPHM TSEKTVLQGY SIPKGTVVLP NLWSIHRDPV IWEKPDDFCP
460 470 480 490 500
HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ LAKMELFLMF VSLMQSFTFA
510 520 530
LPEGSEKPIM TGRFGLTLAP HPFNVTVSKR
Length:530
Mass (Da):60,399
Last modified:July 5, 2005 - v1
Checksum:i7BDF8BD34265801A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097442 mRNA. Translation: AAH97442.1.
RefSeqiNP_001019950.1. NM_001024779.1.
XP_006233372.1. XM_006233310.2.
UniGeneiRn.161862.

Genome annotation databases

EnsembliENSRNOT00000055570; ENSRNOP00000052433; ENSRNOG00000011053.
GeneIDi310848.
KEGGirno:310848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097442 mRNA. Translation: AAH97442.1 .
RefSeqi NP_001019950.1. NM_001024779.1.
XP_006233372.1. XM_006233310.2.
UniGenei Rn.161862.

3D structure databases

ProteinModelPortali Q4V8D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000052433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055570 ; ENSRNOP00000052433 ; ENSRNOG00000011053 .
GeneIDi 310848.
KEGGi rno:310848.

Organism-specific databases

CTDi 113612.
RGDi 1309433. Cyp2u1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q4V8D1.
KOi K07422.
OMAi IEEFAYV.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q4V8D1.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_198836. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi 662741.
PROi Q4V8D1.

Gene expression databases

Genevestigatori Q4V8D1.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1."
    Karlgren M., Backlund M., Johansson I., Oscarson M., Ingelman-Sundberg M.
    Biochem. Biophys. Res. Commun. 315:679-685(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCP2U1_RAT
AccessioniPrimary (citable) accession number: Q4V8D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3