SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4V8C8

- CDC73_RAT

UniProt

Q4V8C8 - CDC73_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Parafibromin
Gene
Cdc73, Hrpt2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors By similarity.

GO - Molecular functioni

  1. RNA polymerase II core binding Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. cell cycle Source: UniProtKB-KW
  3. cellular response to lipopolysaccharide Source: UniProtKB
  4. endodermal cell fate commitment Source: UniProtKB
  5. mRNA polyadenylation Source: UniProtKB
  6. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  7. negative regulation of cell proliferation Source: UniProtKB
  8. negative regulation of myeloid cell differentiation Source: UniProtKB
  9. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  10. positive regulation of Wnt signaling pathway Source: UniProtKB
  11. positive regulation of mRNA 3'-end processing Source: UniProtKB
  12. positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
  13. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. stem cell maintenance Source: UniProtKB
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Parafibromin
Alternative name(s):
Cell division cycle protein 73 homolog
Hyperparathyroidism 2 protein homolog
Gene namesi
Name:Cdc73
Synonyms:Hrpt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1311766. Cdc73.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Cdc73/Paf1 complex Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 531530Parafibromin
PRO_0000191805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei212 – 2121Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4V8C8.
PRIDEiQ4V8C8.

PTM databases

PhosphoSiteiQ4V8C8.

Expressioni

Gene expression databases

GenevestigatoriQ4V8C8.

Interactioni

Subunit structurei

Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, KMT2A/MLL1 and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004495.

Structurei

3D structure databases

ProteinModelPortaliQ4V8C8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 531332Interaction with POLR2A and PAF1 By similarity
Add
BLAST
Regioni200 – 25051Interaction with CTNNB1 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi125 – 13915Nuclear localization signal By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi361 – 3644Poly-Ile

Sequence similaritiesi

Belongs to the CDC73 family.

Phylogenomic databases

eggNOGiCOG5157.
HOGENOMiHOG000007819.
HOVERGENiHBG055033.
InParanoidiQ4V8C8.
KOiK15175.
PhylomeDBiQ4V8C8.

Family and domain databases

InterProiIPR007852. RNA_pol_access_fac_Cdc73.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 1 hit.
PfamiPF05179. CDC73. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8C8-1 [UniParc]FASTAAdd to Basket

« Hide

MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ    50
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG 100
EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK 150
ERLAARLEGH KEGIVQTEQI RSLSEAMLVE KIAAIKAKIM AKKRSTIKTD 200
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFSKNIF 250
AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG 300
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP 350
PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE 400
NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP 450
AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS 500
YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F 531
Length:531
Mass (Da):60,603
Last modified:July 5, 2005 - v1
Checksum:iC99EFF505A4C48FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097445 mRNA. Translation: AAH97445.1.
RefSeqiNP_001019940.1. NM_001024769.1.
UniGeneiRn.162332.

Genome annotation databases

GeneIDi304832.
KEGGirno:304832.
UCSCiRGD:1311766. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097445 mRNA. Translation: AAH97445.1 .
RefSeqi NP_001019940.1. NM_001024769.1.
UniGenei Rn.162332.

3D structure databases

ProteinModelPortali Q4V8C8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004495.

PTM databases

PhosphoSitei Q4V8C8.

Proteomic databases

PaxDbi Q4V8C8.
PRIDEi Q4V8C8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 304832.
KEGGi rno:304832.
UCSCi RGD:1311766. rat.

Organism-specific databases

CTDi 79577.
RGDi 1311766. Cdc73.

Phylogenomic databases

eggNOGi COG5157.
HOGENOMi HOG000007819.
HOVERGENi HBG055033.
InParanoidi Q4V8C8.
KOi K15175.
PhylomeDBi Q4V8C8.

Miscellaneous databases

NextBioi 653711.
PROi Q4V8C8.

Gene expression databases

Genevestigatori Q4V8C8.

Family and domain databases

InterProi IPR007852. RNA_pol_access_fac_Cdc73.
[Graphical view ]
PANTHERi PTHR12466. PTHR12466. 1 hit.
Pfami PF05179. CDC73. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCDC73_RAT
AccessioniPrimary (citable) accession number: Q4V8C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi