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Q4V8C6

- Q4V8C6_RAT

UniProt

Q4V8C6 - Q4V8C6_RAT

Protein

Suppressor of fused homolog

Gene

Sufu

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).UniRule annotation

    GO - Biological processi

    1. cytoplasmic sequestering of transcription factor Source: Ensembl
    2. heart looping Source: Ensembl
    3. negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    4. negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
    5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. neural tube closure Source: Ensembl
    7. skin development Source: Ensembl
    8. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: Ensembl
    9. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor of fused homologUniRule annotation
    Gene namesi
    Name:SufuImported
    ORF Names:rCG_57679Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1559462. Sufu.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. primary cilium Source: Ensembl

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ4V8C6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026987.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SUFU family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG72477.
    GeneTreeiENSGT00390000009747.
    HOGENOMiHOG000007864.
    HOVERGENiHBG061539.
    InParanoidiQ4V8C6.
    KOiK06229.
    OMAiGDTAITF.
    OrthoDBiEOG7RV9FV.
    TreeFamiTF324548.

    Family and domain databases

    InterProiIPR020941. SUFU-like_domain.
    IPR024314. SUFU_C.
    IPR007768. Suppressor_of_fused.
    IPR016591. Suppressor_of_fused_euk.
    [Graphical view]
    PANTHERiPTHR10928. PTHR10928. 1 hit.
    PfamiPF05076. SUFU. 1 hit.
    PF12470. SUFU_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011844. Suppressor_of_fused_protein. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4V8C6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN    50
    PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG 100
    DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ 150
    SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI 200
    VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH 250
    LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDDEDSR SICLGTQPRR 300
    LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTYDR APSRKDSLGS 350
    DISTAVIPHE LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS 400
    ITGDMAITFV STGVEGAFAT EEHPYAAHGP WLQILLTEEF VEKMLEDLED 450
    LTSPEEFKLP KEYSWPEKKL KVSILPDVVF DSPLH 485
    Length:485
    Mass (Da):54,081
    Last modified:July 5, 2005 - v1
    Checksum:iE4E70580C797155D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010844 Genomic DNA. No translation available.
    AABR06010845 Genomic DNA. No translation available.
    BC097447 mRNA. Translation: AAH97447.1.
    CH473986 Genomic DNA. Translation: EDL94350.1.
    RefSeqiNP_001020070.1. NM_001024899.1.
    UniGeneiRn.211670.

    Genome annotation databases

    EnsembliENSRNOT00000026987; ENSRNOP00000026987; ENSRNOG00000019807.
    GeneIDi361769.
    KEGGirno:361769.
    UCSCiRGD:1559462. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010844 Genomic DNA. No translation available.
    AABR06010845 Genomic DNA. No translation available.
    BC097447 mRNA. Translation: AAH97447.1 .
    CH473986 Genomic DNA. Translation: EDL94350.1 .
    RefSeqi NP_001020070.1. NM_001024899.1.
    UniGenei Rn.211670.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026987 ; ENSRNOP00000026987 ; ENSRNOG00000019807 .
    GeneIDi 361769.
    KEGGi rno:361769.
    UCSCi RGD:1559462. rat.

    Organism-specific databases

    CTDi 51684.
    RGDi 1559462. Sufu.

    Phylogenomic databases

    eggNOGi NOG72477.
    GeneTreei ENSGT00390000009747.
    HOGENOMi HOG000007864.
    HOVERGENi HBG061539.
    InParanoidi Q4V8C6.
    KOi K06229.
    OMAi GDTAITF.
    OrthoDBi EOG7RV9FV.
    TreeFami TF324548.

    Miscellaneous databases

    NextBioi 677549.
    PROi Q4V8C6.

    Gene expression databases

    Genevestigatori Q4V8C6.

    Family and domain databases

    InterProi IPR020941. SUFU-like_domain.
    IPR024314. SUFU_C.
    IPR007768. Suppressor_of_fused.
    IPR016591. Suppressor_of_fused_euk.
    [Graphical view ]
    PANTHERi PTHR10928. PTHR10928. 1 hit.
    Pfami PF05076. SUFU. 1 hit.
    PF12470. SUFU_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011844. Suppressor_of_fused_protein. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ4V8C6_RAT
    AccessioniPrimary (citable) accession number: Q4V8C6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3