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Protein

Suppressor of fused homolog

Gene

Sufu

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5632684 Hedgehog 'on' state

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of fused homologUniRule annotation
Gene namesi
Name:SufuImported
ORF Names:rCG_57679Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1559462 Sufu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000019807

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026987

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 240SUFUInterPro annotationAdd BLAST177
Domaini254 – 474SUFU_CInterPro annotationAdd BLAST221

Sequence similaritiesi

Belongs to the SUFU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IFRJ Eukaryota
ENOG410XRUC LUCA
GeneTreeiENSGT00390000009747
HOGENOMiHOG000007864
HOVERGENiHBG061539
KOiK06229
OMAiGDNIPWR
OrthoDBiEOG091G132G
TreeFamiTF324548

Family and domain databases

Gene3Di3.30.1360.230, 1 hit
InterProiView protein in InterPro
IPR020941 SUFU-like_domain
IPR024314 SUFU_C
IPR038489 SUFU_C_sf
IPR037181 SUFU_N
IPR007768 Suppressor_of_fused
IPR016591 Suppressor_of_fused_euk
PANTHERiPTHR10928 PTHR10928, 1 hit
PfamiView protein in Pfam
PF05076 SUFU, 1 hit
PF12470 SUFU_C, 1 hit
PIRSFiPIRSF011844 Suppressor_of_fused_protein, 1 hit
SUPFAMiSSF103359 SSF103359, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V8C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN
60 70 80 90 100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG
110 120 130 140 150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ
160 170 180 190 200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI
210 220 230 240 250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH
260 270 280 290 300
LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDDEDSR SICLGTQPRR
310 320 330 340 350
LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTYDR APSRKDSLGS
360 370 380 390 400
DISTAVIPHE LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS
410 420 430 440 450
ITGDMAITFV STGVEGAFAT EEHPYAAHGP WLQILLTEEF VEKMLEDLED
460 470 480
LTSPEEFKLP KEYSWPEKKL KVSILPDVVF DSPLH
Length:485
Mass (Da):54,081
Last modified:July 5, 2005 - v1
Checksum:iE4E70580C797155D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097694 Genomic DNA No translation available.
BC097447 mRNA Translation: AAH97447.1
CH473986 Genomic DNA Translation: EDL94350.1
RefSeqiNP_001020070.1, NM_001024899.1
UniGeneiRn.211670

Genome annotation databases

EnsembliENSRNOT00000026987; ENSRNOP00000026987; ENSRNOG00000019807
GeneIDi361769
KEGGirno:361769
UCSCiRGD:1559462 rat

Similar proteinsi

Entry informationi

Entry nameiQ4V8C6_RAT
AccessioniPrimary (citable) accession number: Q4V8C6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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