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Protein

Suppressor of fused homolog

Gene

Sufu

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5610787. Hedgehog 'off' state.
R-RNO-5632684. Hedgehog 'on' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of fused homologUniRule annotation
Gene namesi
Name:SufuImported
ORF Names:rCG_57679Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1559462. Sufu.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000019807.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026987.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 240SUFUInterPro annotationAdd BLAST177
Domaini254 – 474SUFU_CInterPro annotationAdd BLAST221

Sequence similaritiesi

Belongs to the SUFU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IFRJ. Eukaryota.
ENOG410XRUC. LUCA.
GeneTreeiENSGT00390000009747.
HOGENOMiHOG000007864.
HOVERGENiHBG061539.
KOiK06229.
OMAiGDNIPWR.
OrthoDBiEOG091G132G.
TreeFamiTF324548.

Family and domain databases

InterProiIPR020941. SUFU-like_domain.
IPR024314. SUFU_C.
IPR007768. Suppressor_of_fused.
IPR016591. Suppressor_of_fused_euk.
[Graphical view]
PANTHERiPTHR10928. PTHR10928. 1 hit.
PfamiPF05076. SUFU. 1 hit.
PF12470. SUFU_C. 1 hit.
[Graphical view]
PIRSFiPIRSF011844. Suppressor_of_fused_protein. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V8C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN
60 70 80 90 100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG
110 120 130 140 150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ
160 170 180 190 200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI
210 220 230 240 250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH
260 270 280 290 300
LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDDEDSR SICLGTQPRR
310 320 330 340 350
LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTYDR APSRKDSLGS
360 370 380 390 400
DISTAVIPHE LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS
410 420 430 440 450
ITGDMAITFV STGVEGAFAT EEHPYAAHGP WLQILLTEEF VEKMLEDLED
460 470 480
LTSPEEFKLP KEYSWPEKKL KVSILPDVVF DSPLH
Length:485
Mass (Da):54,081
Last modified:July 5, 2005 - v1
Checksum:iE4E70580C797155D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097694 Genomic DNA. No translation available.
BC097447 mRNA. Translation: AAH97447.1.
CH473986 Genomic DNA. Translation: EDL94350.1.
RefSeqiNP_001020070.1. NM_001024899.1.
UniGeneiRn.211670.

Genome annotation databases

EnsembliENSRNOT00000026987; ENSRNOP00000026987; ENSRNOG00000019807.
GeneIDi361769.
KEGGirno:361769.
UCSCiRGD:1559462. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097694 Genomic DNA. No translation available.
BC097447 mRNA. Translation: AAH97447.1.
CH473986 Genomic DNA. Translation: EDL94350.1.
RefSeqiNP_001020070.1. NM_001024899.1.
UniGeneiRn.211670.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026987; ENSRNOP00000026987; ENSRNOG00000019807.
GeneIDi361769.
KEGGirno:361769.
UCSCiRGD:1559462. rat.

Organism-specific databases

CTDi51684.
RGDi1559462. Sufu.

Phylogenomic databases

eggNOGiENOG410IFRJ. Eukaryota.
ENOG410XRUC. LUCA.
GeneTreeiENSGT00390000009747.
HOGENOMiHOG000007864.
HOVERGENiHBG061539.
KOiK06229.
OMAiGDNIPWR.
OrthoDBiEOG091G132G.
TreeFamiTF324548.

Enzyme and pathway databases

ReactomeiR-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5610787. Hedgehog 'off' state.
R-RNO-5632684. Hedgehog 'on' state.

Gene expression databases

BgeeiENSRNOG00000019807.

Family and domain databases

InterProiIPR020941. SUFU-like_domain.
IPR024314. SUFU_C.
IPR007768. Suppressor_of_fused.
IPR016591. Suppressor_of_fused_euk.
[Graphical view]
PANTHERiPTHR10928. PTHR10928. 1 hit.
PfamiPF05076. SUFU. 1 hit.
PF12470. SUFU_C. 1 hit.
[Graphical view]
PIRSFiPIRSF011844. Suppressor_of_fused_protein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ4V8C6_RAT
AccessioniPrimary (citable) accession number: Q4V8C6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.