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Protein

ADP-ribosylation factor-like protein 2-binding protein

Gene

Arl2bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 2-binding protein
Short name:
ARF-like 2-binding protein
Alternative name(s):
Binder of ARF2 protein 1
Gene namesi
Name:Arl2bp
Synonyms:Bart, Bart1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1561471 Arl2bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871171 – 163ADP-ribosylation factor-like protein 2-binding proteinAdd BLAST163

Proteomic databases

PaxDbiQ4V8C5
PRIDEiQ4V8C5

Expressioni

Tissue specificityi

Ubiquitous with higher expression in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, spleen and heart (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000016991
ExpressionAtlasiQ4V8C5 baseline and differential
GenevisibleiQ4V8C5 RN

Interactioni

Subunit structurei

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4V8C5
SMRiQ4V8C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL2BP family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015052
HOGENOMiHOG000024955
HOVERGENiHBG105565
InParanoidiQ4V8C5
KOiK16742
PhylomeDBiQ4V8C5

Family and domain databases

InterProiView protein in InterPro
IPR023379 ARF-like_2-bdp_dom
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4V8C5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALEEESFA LSFSSASDAE FDAVVGCLED IIMDAEFQLL QRSFMDKYYQ
60 70 80 90 100
EFEDTEENKL TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH
110 120 130 140 150
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK
160
SSSTPASQNN LRH
Length:163
Mass (Da):18,683
Last modified:May 15, 2007 - v2
Checksum:iA1998B08C0383825
GO
Isoform 2 (identifier: Q4V8C5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):15,289
Checksum:iA64B0F45470E25E7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253211 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097448 mRNA Translation: AAH97448.1
CV113398 mRNA No translation available.
RefSeqiNP_001020077.1, NM_001024906.1 [Q4V8C5-2]
XP_006255182.1, XM_006255120.3 [Q4V8C5-1]
XP_017456828.1, XM_017601339.1 [Q4V8C5-2]
UniGeneiRn.985

Genome annotation databases

EnsembliENSRNOT00000023455; ENSRNOP00000023455; ENSRNOG00000016991 [Q4V8C5-2]
GeneIDi498910
KEGGirno:498910
UCSCiRGD:1561471 rat [Q4V8C5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAR2BP_RAT
AccessioniPrimary (citable) accession number: Q4V8C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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