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Protein

ADP-ribosylation factor-like protein 2-binding protein

Gene

Arl2bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 2-binding protein
Short name:
ARF-like 2-binding protein
Alternative name(s):
Binder of ARF2 protein 1
Gene namesi
Name:Arl2bp
Synonyms:Bart, Bart1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1561471. Arl2bp.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • microtubule organizing center Source: UniProtKB-SubCell
  • mitochondrial intermembrane space Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163ADP-ribosylation factor-like protein 2-binding proteinPRO_0000287117Add
BLAST

Proteomic databases

PaxDbiQ4V8C5.
PRIDEiQ4V8C5.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, spleen and heart (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ4V8C5. baseline and differential.
GenevisibleiQ4V8C5. RN.

Interactioni

Subunit structurei

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4V8C5.
SMRiQ4V8C5. Positions 17-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL2BP family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015052.
HOGENOMiHOG000024955.
HOVERGENiHBG105565.
InParanoidiQ4V8C5.
KOiK16742.
OMAiFMAFKEM.
OrthoDBiEOG7BCNDK.
PhylomeDBiQ4V8C5.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4V8C5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALEEESFA LSFSSASDAE FDAVVGCLED IIMDAEFQLL QRSFMDKYYQ
60 70 80 90 100
EFEDTEENKL TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH
110 120 130 140 150
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK
160
SSSTPASQNN LRH
Length:163
Mass (Da):18,683
Last modified:May 15, 2007 - v2
Checksum:iA1998B08C0383825
GO
Isoform 2 (identifier: Q4V8C5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):15,289
Checksum:iA64B0F45470E25E7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_025321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097448 mRNA. Translation: AAH97448.1.
CV113398 mRNA. No translation available.
RefSeqiNP_001020077.1. NM_001024906.1. [Q4V8C5-2]
XP_006255182.1. XM_006255120.2. [Q4V8C5-1]
UniGeneiRn.985.

Genome annotation databases

EnsembliENSRNOT00000023455; ENSRNOP00000023455; ENSRNOG00000016991. [Q4V8C5-2]
GeneIDi498910.
KEGGirno:498910.
UCSCiRGD:1561471. rat. [Q4V8C5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097448 mRNA. Translation: AAH97448.1.
CV113398 mRNA. No translation available.
RefSeqiNP_001020077.1. NM_001024906.1. [Q4V8C5-2]
XP_006255182.1. XM_006255120.2. [Q4V8C5-1]
UniGeneiRn.985.

3D structure databases

ProteinModelPortaliQ4V8C5.
SMRiQ4V8C5. Positions 17-136.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ4V8C5.
PRIDEiQ4V8C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023455; ENSRNOP00000023455; ENSRNOG00000016991. [Q4V8C5-2]
GeneIDi498910.
KEGGirno:498910.
UCSCiRGD:1561471. rat. [Q4V8C5-1]

Organism-specific databases

CTDi23568.
RGDi1561471. Arl2bp.

Phylogenomic databases

GeneTreeiENSGT00390000015052.
HOGENOMiHOG000024955.
HOVERGENiHBG105565.
InParanoidiQ4V8C5.
KOiK16742.
OMAiFMAFKEM.
OrthoDBiEOG7BCNDK.
PhylomeDBiQ4V8C5.

Enzyme and pathway databases

ReactomeiR-RNO-422356. Regulation of insulin secretion.

Miscellaneous databases

NextBioi701232.
PROiQ4V8C5.

Gene expression databases

ExpressionAtlasiQ4V8C5. baseline and differential.
GenevisibleiQ4V8C5. RN.

Family and domain databases

Gene3Di1.20.1520.10. 1 hit.
InterProiIPR023379. ARF-like_2-bdp_dom.
[Graphical view]
PfamiPF11527. ARL2_Bind_BART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  2. "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter."
    Sharer J.D., Shern J.F., Van Valkenburgh H., Wallace D.C., Kahn R.A.
    Mol. Biol. Cell 13:71-83(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAR2BP_RAT
AccessioniPrimary (citable) accession number: Q4V8C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 17, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.