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Protein

Echinoderm microtubule-associated protein-like 1

Gene

Eml1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 1
Short name:
EMAP-1
Gene namesi
Name:Eml1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306374 Eml1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843871 – 814Echinoderm microtubule-associated protein-like 1Add BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8C3
PRIDEiQ4V8C3

PTM databases

iPTMnetiQ4V8C3
PhosphoSitePlusiQ4V8C3

Interactioni

Subunit structurei

Binds repolymerizing microtubules. Binds unpolymerized tubulins via its WD repeat region (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ4V8C3, 1 interactor
STRINGi10116.ENSRNOP00000067636

Structurei

3D structure databases

ProteinModelPortaliQ4V8C3
SMRiQ4V8C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati260 – 309WD 1Add BLAST50
Repeati314 – 357WD 2Add BLAST44
Repeati362 – 399WD 3Add BLAST38
Repeati408 – 445WD 4Add BLAST38
Repeati449 – 488WD 5Add BLAST40
Repeati492 – 529WD 6Add BLAST38
Repeati534 – 571WD 7Add BLAST38
Repeati577 – 612WD 8Add BLAST36
Repeati616 – 654WD 9Add BLAST39
Repeati663 – 700WD 10Add BLAST38
Repeati708 – 767WD 11Add BLAST60
Repeati774 – 813WD 12Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 814Tandem atypical propeller in EMLsBy similarityAdd BLAST640

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 172Ser-richAdd BLAST65

Domaini

Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain.By similarity

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG051470
InParanoidiQ4V8C3
KOiK18595
PhylomeDBiQ4V8C3

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4V8C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEISDRIAS LEQRVQMQED
60 70 80 90 100
DIQLLKSALA DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG
110 120 130 140 150
TVLPKKPSAS LPSPSGSRKE MVVPVTKSIN RTSSSERVSP GGRRESSGDS
160 170 180 190 200
KGSRNRTGST SSSSSGKKNS ESKPKEPTFS PEEGYVKMFL RGRPVTMYMP
210 220 230 240 250
KDQVDSYSLE AKAELPTKRL KLEWVYGYRG RDCRNNLYLL PTGETVYFIA
260 270 280 290 300
SVVVLYNVEE QLQRHYAGHN DDVKCLAVHP DRITIATGQV AGTSKDGKQL
310 320 330 340 350
PPHVRIWDSV TLNTLHVIGI GFFDRAVTCI AFSKSNGGSH LCAVDDSNDH
360 370 380 390 400
VLSVWDWQRE ERLADVKCSN EAVFAADFHP TDTNIIVTCG KSHLYFWTLE
410 420 430 440 450
GNSLNKKQGL FEKQEKPKFV LCVTFSENGD TITGDSSGNI LVWGKGTNRI
460 470 480 490 500
SYAVQGAHEG GIFALCMLRD GTLVSGGGKD RRLISWNGNY QKLHKAEIPE
510 520 530 540 550
QFGPIRTVAE GKGNVILIGT TRNFVLQGTL TGDFTPITQG HTDELWGLAI
560 570 580 590 600
HASKPQFLTC GHDKHATLWD AVGHRPVWDK IIEDPAQSSG FHPSGSVVAV
610 620 630 640 650
GTLTGRWFVF DTETKDLVTV HTDGNEQLSV MRYSPDGNFL AIGSHDNCIY
660 670 680 690 700
IYGVSDNGRK YTRVGKCSGH SSFITHLDWS VNSQFLVSNS GDYEILYWVP
710 720 730 740 750
SACKQVVSVE TTRDIEWATY TCTLGFHVFG VWPEGSDGTD INAVCRAHEK
760 770 780 790 800
KLLSTGDDFG KVHLFSYPCS QFRAPSHIYS GHSSHVTNVD FLCEDSHLIS
810
TGGKDTSIMQ WRVI
Length:814
Mass (Da):89,802
Last modified:April 17, 2007 - v2
Checksum:iCF8DD37A5057BD0D
GO
Isoform 2 (identifier: Q4V8C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available.
Show »
Length:783
Mass (Da):86,533
Checksum:i10FCB3CBBAC15AF6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244791 – 31Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03049402 Genomic DNA No translation available.
AABR03049711 Genomic DNA No translation available.
AABR03050272 Genomic DNA No translation available.
BC097450 mRNA Translation: AAH97450.1
RefSeqiNP_001020912.1, NM_001025741.1 [Q4V8C3-2]
UniGeneiRn.211693

Genome annotation databases

GeneIDi362783
KEGGirno:362783
UCSCiRGD:1306374 rat [Q4V8C3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEMAL1_RAT
AccessioniPrimary (citable) accession number: Q4V8C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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