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Protein

Inactive hydroxysteroid dehydrogenase-like protein 1

Gene

Hsdl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125NADPBy similarity1
Binding sitei222NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 80NADPBy similarity7

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive hydroxysteroid dehydrogenase-like protein 1
Gene namesi
Name:Hsdl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1308433. Hsdl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136742 – 330Inactive hydroxysteroid dehydrogenase-like protein 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4V8B7.
PRIDEiQ4V8B7.

PTM databases

SwissPalmiQ4V8B7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015576.

Interactioni

Subunit structurei

Interacts with STYXL1.By similarity

Protein-protein interaction databases

IntActiQ4V8B7. 1 interactor.
STRINGi10116.ENSRNOP00000020860.

Structurei

3D structure databases

ProteinModelPortaliQ4V8B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 82Required for mitochondria translocationBy similarityAdd BLAST81

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1014. Eukaryota.
COG0300. LUCA.
GeneTreeiENSGT00390000010069.
HOGENOMiHOG000039237.
HOVERGENiHBG005478.
InParanoidiQ4V8B7.
OMAiFLHRCSW.
OrthoDBiEOG091G06T2.
PhylomeDBiQ4V8B7.
TreeFamiTF314591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V8B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVDSFYLL YREIARSCSC YVEALALVGA WYTARKSIPV ICDFYSLVRL
60 70 80 90 100
HFIPRLGSRP DLIKQYGRWA VISGATDGIG KAYAEELASH GLNIILISQE
110 120 130 140 150
EEKLQAVAKH IADTYRVETL VLVADFSRGR EIYAPIREAL RDRDIGILVN
160 170 180 190 200
DVGAFYPYPQ YFSQVPEDTI WDIVNVNIAA ASLMVHIVLP GMVERKKGAI
210 220 230 240 250
VTVSSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG IFVQSLIPFY
260 270 280 290 300
VTSSVTAPGS FLRRCPWLAP SPRVYAQHAV STLGISKRTT GYWSHSIQFL
310 320 330
FAQYMPEWLW VWGANLLNRS LRKEALSSQA
Length:330
Mass (Da):36,908
Last modified:July 5, 2005 - v1
Checksum:i2596B7EAE1337244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097457 mRNA. Translation: AAH97457.1.
RefSeqiNP_001020067.1. NM_001024896.1.
XP_006255775.1. XM_006255713.3.
XP_006255776.1. XM_006255714.3.
UniGeneiRn.199069.

Genome annotation databases

EnsembliENSRNOT00000020859; ENSRNOP00000020860; ENSRNOG00000015576.
GeneIDi361418.
KEGGirno:361418.
UCSCiRGD:1308433. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097457 mRNA. Translation: AAH97457.1.
RefSeqiNP_001020067.1. NM_001024896.1.
XP_006255775.1. XM_006255713.3.
XP_006255776.1. XM_006255714.3.
UniGeneiRn.199069.

3D structure databases

ProteinModelPortaliQ4V8B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4V8B7. 1 interactor.
STRINGi10116.ENSRNOP00000020860.

PTM databases

SwissPalmiQ4V8B7.

Proteomic databases

PaxDbiQ4V8B7.
PRIDEiQ4V8B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020859; ENSRNOP00000020860; ENSRNOG00000015576.
GeneIDi361418.
KEGGirno:361418.
UCSCiRGD:1308433. rat.

Organism-specific databases

CTDi83693.
RGDi1308433. Hsdl1.

Phylogenomic databases

eggNOGiKOG1014. Eukaryota.
COG0300. LUCA.
GeneTreeiENSGT00390000010069.
HOGENOMiHOG000039237.
HOVERGENiHBG005478.
InParanoidiQ4V8B7.
OMAiFLHRCSW.
OrthoDBiEOG091G06T2.
PhylomeDBiQ4V8B7.
TreeFamiTF314591.

Miscellaneous databases

PROiQ4V8B7.

Gene expression databases

BgeeiENSRNOG00000015576.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSDL1_RAT
AccessioniPrimary (citable) accession number: Q4V8B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.