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Protein

Mediator of RNA polymerase II transcription subunit 24

Gene

Med24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

  • histone acetyltransferase activity Source: RGD
  • RNA polymerase II transcription cofactor activity Source: GO_Central
  • transcription coactivator activity Source: RGD

GO - Biological processi

  • protein heterooligomerization Source: RGD
  • protein ubiquitination Source: RGD
  • stem cell population maintenance Source: Ensembl
  • transcription by RNA polymerase II Source: Ensembl

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 24
Alternative name(s):
Mediator complex subunit 24
Thyroid hormone receptor-associated protein 4
Gene namesi
Name:Med24
Synonyms:Thrap4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1564565 Med24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059131 – 987Mediator of RNA polymerase II transcription subunit 24Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei860PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8B3
PRIDEiQ4V8B3

PTM databases

iPTMnetiQ4V8B3
PhosphoSitePlusiQ4V8B3

Expressioni

Gene expression databases

BgeeiENSRNOG00000008711
GenevisibleiQ4V8B3 RN

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011947

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi128 – 132LXXLL motif 15
Motifi344 – 348LXXLL motif 25
Motifi446 – 450LXXLL motif 35
Motifi555 – 559LXXLL motif 45
Motifi786 – 790LXXLL motif 55
Motifi855 – 859LXXLL motif 65

Sequence similaritiesi

Belongs to the Mediator complex subunit 24 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF72 Eukaryota
ENOG410YPDT LUCA
GeneTreeiENSGT00390000016438
HOGENOMiHOG000293419
HOVERGENiHBG055588
InParanoidiQ4V8B3
KOiK15167
OMAiLLNDWTK
OrthoDBiEOG091G027P

Family and domain databases

InterProiView protein in InterPro
IPR021429 Mediator_Med24_N
PfamiView protein in Pfam
PF11277 Med24_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V8B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLAEALLEQA
60 70 80 90 100
MIGPSPNPLI LSYLKYAISS QMVSYSSVLT AISKFDDFSR DLCVQALLDI
110 120 130 140 150
MDMFCDRLSC HGKAEECIGL CRALLSALHW LLRCTAASAE RLQEGLEAGS
160 170 180 190 200
AVTGEKQLAL CLQCLEKTLS STKNRALLHI AKLEEASSWT AIEHCLLKLG
210 220 230 240 250
EILANLSNPQ LRSQAEHCGT LIRSIPTMLS VHSEQLHKTG FPTIHALILL
260 270 280 290 300
EGTMNLTGEM QPLVEQLMMV KRMQHIPTPL FVLEIWKACF VGLIESPEGT
310 320 330 340 350
QELKWTAFTY LKIPQVLVKL KKYFHGDKDF TEDVNCAFEF LLKLTPLLDK
360 370 380 390 400
ADQRCNCDCT NFLLQECNKQ GLLSEASFAS LVSKRTADRD PQLKSSENAN
410 420 430 440 450
IQPNPGLILR AEPTVTNILK TMDADHSKSP EGLLGVLGHM LSGKSLDLLL
460 470 480 490 500
AAAAATGKLK SFARKFINLN EFTTHGSGES TKTASVRALL FDISFLMLCH
510 520 530 540 550
VAQTYGSEVI LSESSSGEEV PFFETWMQTC MPEEGKILNP DHPCFRPDST
560 570 580 590 600
KVESLVALLN NSSEMKLVQM KWHEACLSIS AAILEILNAW ENGVLAFESI
610 620 630 640 650
QKITDNIKGK VCSLAVCAVA WLVAHVRMLG LDEREKSLQM IRQLAGPLYS
660 670 680 690 700
ENTLQFYNER VVIMNSILEH MCADVLQQTA TQIKFPSTGV DTMPYWNLLP
710 720 730 740 750
PKRPIKEVLT DIFAKVLEKG WVDSRSIHIL DTLLHMGGVY WFCNNLIKEL
760 770 780 790 800
LKETRKEHTL RAVQLLYSIF CLDMQQVTLV LLGHILPGLL TDSSKWHSLM
810 820 830 840 850
DPPGTALAKL AVWCALSSYS SHKGQASSRQ KKRHREDIED YISLFPVEDM
860 870 880 890 900
QPSKLMRLLS SNEDDASILS SPTDRSMNSS LSASQLHTVN MRDPLNRVLA
910 920 930 940 950
NLFLLISSVL GSRTAGPHTQ FVQWFMEECV DCLEQDSRGS ILQFMPFTTV
960 970 980
SELVKVSAMS SPKVVLAITD LSLPLGRQVA AKAIAAL
Length:987
Mass (Da):110,081
Last modified:July 5, 2005 - v1
Checksum:i0456BD64D5245E56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097461 mRNA Translation: AAH97461.1
RefSeqiNP_001029251.1, NM_001034079.1
UniGeneiRn.7360

Genome annotation databases

EnsembliENSRNOT00000011947; ENSRNOP00000011947; ENSRNOG00000008711
GeneIDi619436
KEGGirno:619436
UCSCiRGD:1564565 rat

Similar proteinsi

Entry informationi

Entry nameiMED24_RAT
AccessioniPrimary (citable) accession number: Q4V8B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health