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Protein

Proton-coupled amino acid transporter 3

Gene

Slc36a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 3
Short name:
Proton/amino acid transporter 3
Alternative name(s):
Solute carrier family 36 member 3
Tramdorin-2
Gene namesi
Name:Slc36a3
Synonyms:Pat3, Tramd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1309092. Slc36a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 77ExtracellularSequence analysis2
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 144CytoplasmicSequence analysisAdd BLAST46
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 202ExtracellularSequence analysisAdd BLAST37
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 225CytoplasmicSequence analysis2
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 259ExtracellularSequence analysisAdd BLAST13
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 291CytoplasmicSequence analysisAdd BLAST11
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 344ExtracellularSequence analysisAdd BLAST32
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 374CytoplasmicSequence analysis9
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 399ExtracellularSequence analysis4
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 439CytoplasmicSequence analysisAdd BLAST19
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 477ExtracellularSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262061 – 477Proton-coupled amino acid transporter 3Add BLAST477

Proteomic databases

PaxDbiQ4V8B1.
PRIDEiQ4V8B1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021310.
GenevisibleiQ4V8B1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037827.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 33Poly-Ser6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ4V8B1.
KOiK14209.
OMAiYSENISC.
OrthoDBiEOG091G079T.
PhylomeDBiQ4V8B1.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTPLLRED GRCQRNTFGG SKASSKGSSS SSSNNTVSSK KKPRRKADAL
60 70 80 90 100
MFIQIFIHLL KSNIGTGFLG LPLAVKNAGL LVGPVSLLAI GALTVHCMDI
110 120 130 140 150
LLNCACHLTS RLQRSFVNYE ETTMYSLETC PSPWLRTHSV WGRYVVSFLL
160 170 180 190 200
IVTQLGFCSV YFMFMADNLQ QIVEEAHFTS NVCQPRQSLV MTSILDTRFY
210 220 230 240 250
MLTILPFLIL LVLVQNPQVL SIFSTLATIT TLSSLALIFE YLIQIPHHSH
260 270 280 290 300
LPLVASWKTF LLFFGTAIFT FEGVGMVLPL KSQMKSPQQF PAVLYLGMSF
310 320 330 340 350
VIFLYICLGT LGYMKFGADT QASITLNLPN CWLYQSVKLM YSVGIFFTYA
360 370 380 390 400
LQFHVPAEII VPYVVSRASE NWALFIDLTV RAALVCLTCF SAVLIPRLDL
410 420 430 440 450
VISLVGSVSS SALALIIPPL LEIATFYSEN ISCTTIAKDI MISILGLLGC
460 470
VLGTYQALYE MTQQSRFPML NSTNVHT
Length:477
Mass (Da):52,850
Last modified:July 5, 2005 - v1
Checksum:i62E8D79CB75452D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097463 mRNA. Translation: AAH97463.1.
RefSeqiNP_001019935.1. NM_001024764.1.
XP_008765907.1. XM_008767685.2.
UniGeneiRn.75959.

Genome annotation databases

EnsembliENSRNOT00000037274; ENSRNOP00000037827; ENSRNOG00000021310.
GeneIDi303148.
KEGGirno:303148.
UCSCiRGD:1309092. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097463 mRNA. Translation: AAH97463.1.
RefSeqiNP_001019935.1. NM_001024764.1.
XP_008765907.1. XM_008767685.2.
UniGeneiRn.75959.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037827.

Proteomic databases

PaxDbiQ4V8B1.
PRIDEiQ4V8B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037274; ENSRNOP00000037827; ENSRNOG00000021310.
GeneIDi303148.
KEGGirno:303148.
UCSCiRGD:1309092. rat.

Organism-specific databases

CTDi285641.
RGDi1309092. Slc36a3.

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ4V8B1.
KOiK14209.
OMAiYSENISC.
OrthoDBiEOG091G079T.
PhylomeDBiQ4V8B1.
TreeFamiTF314873.

Miscellaneous databases

PROiQ4V8B1.

Gene expression databases

BgeeiENSRNOG00000021310.
GenevisibleiQ4V8B1. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS36A3_RAT
AccessioniPrimary (citable) accession number: Q4V8B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.