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Protein

Oxidation resistance protein 1

Gene

Oxr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protection from oxidative damage.By similarity

GO - Biological processi

  • response to oxidative stress Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidation resistance protein 1
Alternative name(s):
Protein C7
Gene namesi
Name:Oxr1
Synonyms:C7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621857. Oxr1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB-SubCell
  • nucleolus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316471 – 839Oxidation resistance protein 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei111PhosphothreonineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei287PhosphoserineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei334PhosphothreonineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8B0.
PRIDEiQ4V8B0.

PTM databases

iPTMnetiQ4V8B0.
PhosphoSitePlusiQ4V8B0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008019.
ExpressionAtlasiQ4V8B0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010856.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 134LysMPROSITE-ProRule annotationAdd BLAST44
Domaini206 – 261GRAMAdd BLAST56
Domaini703 – 838TLDAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni543 – 570Mediates oxidative antimutator activityBy similarityAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 29Poly-Gly6
Compositional biasi198 – 201Poly-Glu4

Sequence similaritiesi

Belongs to the OXR1 family.Curated
Contains 1 GRAM domain.Curated
Contains 1 LysM domain.PROSITE-ProRule annotation
Contains 1 TLD domain.Curated

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
ENOG4111WZR. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000060321.
HOVERGENiHBG065488.
InParanoidiQ4V8B0.
PhylomeDBiQ4V8B0.

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4V8B0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYLTTFTGK SGRLLRGTAS RLWGLGGGGE ARQVRFEDYL REPAPGDPGC
60 70 80 90 100
GPGELRPPSP TSPEGPDTGQ KKTLDKKDGR RMSFQKPKGT IEYTVESRDS
110 120 130 140 150
LNSIALKFDT TPNELVQLNK LFSRAVVTGQ VLYVPDPEYV SSVESSPSLS
160 170 180 190 200
PVSPLSPTSS EAEFDKTTTP DVVHPKEAPP SSTESSIRPA RVVSSTSEEE
210 220 230 240 250
EAFTEKFLKI NCKYITNGKG TVSGVLLVTP NNIMFDPHKT DPLVQENGCE
260 270 280 290 300
EYGIMCPMEE VMSAAMYKEI LDSKLKESLP IEVDQLSGRG FCHSKKMTGV
310 320 330 340 350
PAEETDSRSR DQGNDSVSTA PRSTEESLSE DVFTESELSP IREELPSSEL
360 370 380 390 400
RQEKSSDASS ESVQTVSQIE VESLTAASES ADVPDHTNAN SGRSSSEVGA
410 420 430 440 450
LSHETGLSSL EIATKEGDKA TGNLQEVSGP KEQSTDIKGQ DNQDSFHHEN
460 470 480 490 500
SLQQEAGEDS LSSGETVELT EKPTVLKDQQ GKELKRDSET EVEELRKLWK
510 520 530 540 550
THSMQQAKQQ RDTIQQVAQR ESKHRGAPAD AHGEGSSLLK EKRRHRLHKF
560 570 580 590 600
LCLRVGKPMR KTFVSQASAT MQQYAQRDKK HEYWFAVPQE RTDHLYAFFI
610 620 630 640 650
QWSPEIYAED TGEYTREPGF IVVKKMAESG PDEAPAGEAA AREWEITTRE
660 670 680 690 700
DINSKQAAPA KADLEPESFR PNLSDPSELL LPDQIEKLTK HLPPRTIGYP
710 720 730 740 750
WTLVYGTGKH GTSLKTLYRT MTGLDTPVLM VIKDSDGQVF GALASEPFKV
760 770 780 790 800
SDGFYGTGET FVFTFCPEFE VFKWTGDNMF FIKGDMDSLA FGGGGGEFAL
810 820 830
WLDGDLYHGR SHSCKTFGNH TLSKKEDFFI QDIEIWAFE
Note: No experimental confirmation available.
Length:839
Mass (Da):92,810
Last modified:April 20, 2010 - v3
Checksum:i0CC16D2DBDE2FB02
GO
Isoform 2 (identifier: Q4V8B0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-510: Missing.
     511-645: RDTIQQVAQR...AGEAAAREWE → MEKAYTLIVF...ELRTLCRRLQ

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):37,765
Checksum:iF6D5B66B62B7951A
GO
Isoform 3 (identifier: Q4V8B0-3) [UniParc]FASTAAdd to basket
Also known as: C7C

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     624-645: KKMAESGPDEAPAGEAAAREWE → MSRLWYGKKGRRHQQVNHKYTL

Show »
Length:216
Mass (Da):24,450
Checksum:i4E1A76CD1A9BE87E
GO

Sequence cautioni

The sequence AAI66763 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178691 – 623Missing in isoform 3. 2 PublicationsAdd BLAST623
Alternative sequenceiVSP_0178701 – 510Missing in isoform 2. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_017871511 – 645RDTIQ…AREWE → MEKAYTLIVFFLLLRLSFIL CGFPEATCFWRINHNEHLES NMRKDCGFILFTIPVHLVED HFRVLLDFPFPLRCAVCLAI LVSRNRILKEKQTAVLIVSD VLPMRFPTPQVVSVAEYHRR IDALNTEELRTLCRRLQ in isoform 2. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_017872624 – 645KKMAE…AREWE → MSRLWYGKKGRRHQQVNHKY TL in isoform 3. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333986 mRNA. Translation: AAK29401.1.
AABR03055922 Genomic DNA. No translation available.
AABR03056092 Genomic DNA. No translation available.
AABR03059133 Genomic DNA. No translation available.
AABR03060217 Genomic DNA. No translation available.
BC081744 mRNA. Translation: AAH81744.1.
BC097465 mRNA. Translation: AAH97465.1.
BC166763 mRNA. Translation: AAI66763.1. Different initiation.
RefSeqiNP_001184261.1. NM_001197332.1. [Q4V8B0-3]
NP_476494.2. NM_057153.3.
XP_017450109.1. XM_017594620.1.
UniGeneiRn.4252.

Genome annotation databases

EnsembliENSRNOT00000079962; ENSRNOP00000074353; ENSRNOG00000056487. [Q4V8B0-3]
GeneIDi117520.
KEGGirno:117520.
UCSCiRGD:621857. rat. [Q4V8B0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333986 mRNA. Translation: AAK29401.1.
AABR03055922 Genomic DNA. No translation available.
AABR03056092 Genomic DNA. No translation available.
AABR03059133 Genomic DNA. No translation available.
AABR03060217 Genomic DNA. No translation available.
BC081744 mRNA. Translation: AAH81744.1.
BC097465 mRNA. Translation: AAH97465.1.
BC166763 mRNA. Translation: AAI66763.1. Different initiation.
RefSeqiNP_001184261.1. NM_001197332.1. [Q4V8B0-3]
NP_476494.2. NM_057153.3.
XP_017450109.1. XM_017594620.1.
UniGeneiRn.4252.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010856.

PTM databases

iPTMnetiQ4V8B0.
PhosphoSitePlusiQ4V8B0.

Proteomic databases

PaxDbiQ4V8B0.
PRIDEiQ4V8B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000079962; ENSRNOP00000074353; ENSRNOG00000056487. [Q4V8B0-3]
GeneIDi117520.
KEGGirno:117520.
UCSCiRGD:621857. rat. [Q4V8B0-1]

Organism-specific databases

CTDi55074.
RGDi621857. Oxr1.

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
ENOG4111WZR. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000060321.
HOVERGENiHBG065488.
InParanoidiQ4V8B0.
PhylomeDBiQ4V8B0.

Miscellaneous databases

PROiQ4V8B0.

Gene expression databases

BgeeiENSRNOG00000008019.
ExpressionAtlasiQ4V8B0. baseline.

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di3.10.350.10. 1 hit.
InterProiIPR018392. LysM_dom.
IPR006571. TLDc_dom.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
SM00584. TLDc. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXR1_RAT
AccessioniPrimary (citable) accession number: Q4V8B0
Secondary accession number(s): B2RYF9, Q99MK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.