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Protein

Zinc finger protein 90

Gene

Zfp90

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of DNA binding Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90
Short name:
Zfp-90
Gene namesi
Name:Zfp90
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1563077. Zfp90.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Zinc finger protein 90PRO_0000233977Add
BLAST

Proteomic databases

PaxDbiQ4V8A8.
PRIDEiQ4V8A8.

PTM databases

iPTMnetiQ4V8A8.
PhosphoSiteiQ4V8A8.

Expressioni

Gene expression databases

ExpressionAtlasiQ4V8A8. baseline and differential.
GenevisibleiQ4V8A8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027209.

Structurei

3D structure databases

ProteinModelPortaliQ4V8A8.
SMRiQ4V8A8. Positions 276-358, 360-413, 492-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri522 – 54423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri550 – 57223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri578 – 60023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ4V8A8.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ4V8A8.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPPTATP QESVTFKDVA VNFTQEEWRH VGPAQRSLYR DVMLENYSHL
60 70 80 90 100
VSLGYQVSKP EVIFKLEQGE EPWISERELQ RPFCPDWKTR PDIKSWSSQQ
110 120 130 140 150
GVSEVSHSAN VWSHATFGDI WGVNTQRHQE SWRRHLGPEA SSQKKITALE
160 170 180 190 200
KIAEQNKFGE DSGLSTDLVP QLDVSSSIRP SECKTFGNNL EYNSELVTQS
210 220 230 240 250
GIPAKKKPYK CDKCRKSFIH RSSLNKHEKI HKDDAYSNGT DQGVPSGRKH
260 270 280 290 300
HECTDCGKTF LWRTQLTEHQ RIHTGEKPFE CNVCGKAFRH SSSLGQHENA
310 320 330 340 350
HTGEKPYQCS LCGKAFQRSS SLVQHQRIHT GEKPYRCNLC GRSFRHSTSL
360 370 380 390 400
TQHEVTHSGE KPFQCKECGK AFSRCSSLVQ HERTHTGEKP FECSICGRAF
410 420 430 440 450
GQSPSLYKHM RIHKRSKPYQ SNNFSIAFEP NIPLTQGESV LTDVKSYHCI
460 470 480 490 500
DCGKDFSHIT DFTEHQRIHA GENSYDSEQA LRQQSLSHPR EKPYQCNVCG
510 520 530 540 550
KAFKRSTSFI EHHRIHTGEK PYECNECGEA FSRLSSLTQH ERTHTGEKPY
560 570 580 590 600
ECIDCGKAFS QSSSLIQHER THTGEKPYEC NECGRAFRKK TNLHDHQRIH
610 620 630
TGEKPYACKE CGKNFSRSSA LTKHHRIHSR NKL
Length:633
Mass (Da):72,438
Last modified:July 5, 2005 - v1
Checksum:i4FAFD3846C712653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097467 mRNA. Translation: AAH97467.1.
RefSeqiNP_001020936.1. NM_001025765.1.
UniGeneiRn.38916.

Genome annotation databases

EnsembliENSRNOT00000027209; ENSRNOP00000027209; ENSRNOG00000020087.
GeneIDi498945.
KEGGirno:498945.
UCSCiRGD:1563077. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097467 mRNA. Translation: AAH97467.1.
RefSeqiNP_001020936.1. NM_001025765.1.
UniGeneiRn.38916.

3D structure databases

ProteinModelPortaliQ4V8A8.
SMRiQ4V8A8. Positions 276-358, 360-413, 492-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027209.

PTM databases

iPTMnetiQ4V8A8.
PhosphoSiteiQ4V8A8.

Proteomic databases

PaxDbiQ4V8A8.
PRIDEiQ4V8A8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027209; ENSRNOP00000027209; ENSRNOG00000020087.
GeneIDi498945.
KEGGirno:498945.
UCSCiRGD:1563077. rat.

Organism-specific databases

CTDi146198.
RGDi1563077. Zfp90.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ4V8A8.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ4V8A8.
TreeFamiTF350822.

Miscellaneous databases

PROiQ4V8A8.

Gene expression databases

ExpressionAtlasiQ4V8A8. baseline and differential.
GenevisibleiQ4V8A8. RN.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZFP90_RAT
AccessioniPrimary (citable) accession number: Q4V8A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.