Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Gene

Dyrk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371ATPPROSITE-ProRule annotationBy similarity
Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi214 – 2229ATPPROSITE-ProRule annotationBy similarity
Nucleotide bindingi287 – 2904ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC:2.7.12.1)
Gene namesi
Name:Dyrk3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310924. Dyrk3.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Dual specificity tyrosine-phosphorylation-regulated kinase 3PRO_0000291538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei368 – 3681PhosphotyrosineBy similarity

Post-translational modificationi

Autophosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V8A3.
PRIDEiQ4V8A3.

PTM databases

PhosphoSiteiQ4V8A3.

Expressioni

Tissue specificityi

Expressed in late pachytene spermatocytes.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006502.

Structurei

3D structure databases

ProteinModelPortaliQ4V8A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 521314Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ4V8A3.
KOiK18669.
PhylomeDBiQ4V8A3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAARERGR KDAALPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPYTNTL
60 70 80 90 100
CNPSEAPVSR RLNITTEPFT RGHTQHFVSG GVMKVEQLFQ EFGSRRTSTL
110 120 130 140 150
QSDGVSNSEK SSPASQGKSS DSLGTVKCSL SSRPSKVLPL TPEQALKQYK
160 170 180 190 200
HHLTAYEKLE IISYPEIYFV GPNAKKRQGV IGGPNNGGYD DADGAYIHVP
210 220 230 240 250
RDHLAYRYEV LKIIGKGSFG QVARVYDHKL RQYVALKMVR NEKRFHRQAA
260 270 280 290 300
EEIRILEHLK KQDKTGSMNV IHMLESFTFR NHVCMAFELL SIDLYELIKK
310 320 330 340 350
NKFQGFSVQL VRKFAQSILQ SLDALHKNKI IHCDLKPENI LLKHHGRSAT
360 370 380 390 400
KVIDFGSSCF EYQKLYTYIQ SRFYRAPEII LGCRYSTPID IWSFGCILAE
410 420 430 440 450
LLTGQPLFPG EDEGDQLACM MELLGMPPQK LLEQSKRAKY FINSKGLPRY
460 470 480 490 500
CSVTTQTDGR VVLLGGRSRR GKKRGPPGSK DWAAALKGCD DYLFIEFLKR
510 520 530 540 550
CLQWDPSARL TPAQALRHPW ISKSAPRPLT TDKVSGKRVV NPTNAFQGLG
560 570 580
SKLPPVVGIA SKLKANLMSE TSGSIPLCSV LPKLIS
Length:586
Mass (Da):65,511
Last modified:July 5, 2005 - v1
Checksum:i9E194D2F960FBE94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097474 mRNA. Translation: AAH97474.1.
RefSeqiNP_001019938.1. NM_001024767.1.
UniGeneiRn.162390.

Genome annotation databases

GeneIDi304775.
KEGGirno:304775.
UCSCiRGD:1310924. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097474 mRNA. Translation: AAH97474.1.
RefSeqiNP_001019938.1. NM_001024767.1.
UniGeneiRn.162390.

3D structure databases

ProteinModelPortaliQ4V8A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006502.

PTM databases

PhosphoSiteiQ4V8A3.

Proteomic databases

PaxDbiQ4V8A3.
PRIDEiQ4V8A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi304775.
KEGGirno:304775.
UCSCiRGD:1310924. rat.

Organism-specific databases

CTDi8444.
RGDi1310924. Dyrk3.

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ4V8A3.
KOiK18669.
PhylomeDBiQ4V8A3.

Miscellaneous databases

NextBioi653596.
PROiQ4V8A3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  2. "The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice."
    Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M.
    Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDYRK3_RAT
AccessioniPrimary (citable) accession number: Q4V8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.