Q4V8A3 (DYRK3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3
EC=2.7.12.1

Gene names

Name:

Dyrk3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	586 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling By similarity. UniProtKB O43781 UniProtKB Q922Y0
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB O43781 UniProtKB Q922Y0
Cofactor	Magnesium By similarity. UniProtKB O43781 UniProtKB Q922Y0
Subcellular location	Nucleus By similarity UniProtKB O43781.
Tissue specificity	Expressed in late pachytene spermatocytes. Ref.2
Post-translational modification	Autophosphorylated on tyrosine residues By similarity. UniProtKB O43781
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 586	586	Dual specificity tyrosine-phosphorylation-regulated kinase 3		PRO_0000291538
Regions
	Domain	208 – 521	314	Protein kinase
	Nucleotide binding	214 – 222	9	ATP By similarity UniProtKB P28523
Sites
	Active site	334	1	Proton acceptor By similarity UniProtKB P28523
	Binding site	237	1	ATP By similarity UniProtKB Q922Y0
Amino acid modifications
	Modified residue	208	1	Phosphotyrosine By similarity UniProtKB O43781
	Modified residue	317	1	Phosphoserine By similarity
	Modified residue	368	1	Phosphotyrosine By similarity UniProtKB Q922Y0

Sequences

	Sequence		Length	Mass (Da)
	Q4V8A3 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 9E194D2F960FBE94	FASTA	586	65,511
	10 20 30 40 50 60 MGGAARERGR KDAALPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPYTNTL CNPSEAPVSR 70 80 90 100 110 120 RLNITTEPFT RGHTQHFVSG GVMKVEQLFQ EFGSRRTSTL QSDGVSNSEK SSPASQGKSS 130 140 150 160 170 180 DSLGTVKCSL SSRPSKVLPL TPEQALKQYK HHLTAYEKLE IISYPEIYFV GPNAKKRQGV 190 200 210 220 230 240 IGGPNNGGYD DADGAYIHVP RDHLAYRYEV LKIIGKGSFG QVARVYDHKL RQYVALKMVR 250 260 270 280 290 300 NEKRFHRQAA EEIRILEHLK KQDKTGSMNV IHMLESFTFR NHVCMAFELL SIDLYELIKK 310 320 330 340 350 360 NKFQGFSVQL VRKFAQSILQ SLDALHKNKI IHCDLKPENI LLKHHGRSAT KVIDFGSSCF 370 380 390 400 410 420 EYQKLYTYIQ SRFYRAPEII LGCRYSTPID IWSFGCILAE LLTGQPLFPG EDEGDQLACM 430 440 450 460 470 480 MELLGMPPQK LLEQSKRAKY FINSKGLPRY CSVTTQTDGR VVLLGGRSRR GKKRGPPGSK 490 500 510 520 530 540 DWAAALKGCD DYLFIEFLKR CLQWDPSARL TPAQALRHPW ISKSAPRPLT TDKVSGKRVV 550 560 570 580 NPTNAFQGLG SKLPPVVGIA SKLKANLMSE TSGSIPLCSV LPKLIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice." Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M. Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed: 17292540] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097474 mRNA. Translation: AAH97474.1.
IPI	IPI00371936.
RefSeq	NP_001019938.1. NM_001024767.1.
UniGene	Rn.162390.
3D structure databases
HSSP	HSSP built from PDB template 2BAJ based on UniProtKB Q16539.
ProteinModelPortal	Q4V8A3.
ModBase	Search...
PTM databases
PhosphoSite	Q4V8A3.
Proteomic databases
PRIDE	Q4V8A3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	304775.
KEGG	rno:304775.
Organism-specific databases
CTD	8444.
RGD	1310924. Dyrk3.
Phylogenomic databases
eggNOG	roNOG05902.
GeneTree	ENSGT00570000079111.
HOVERGEN	HBG051426.
InParanoid	Q4V8A3.
OrthoDB	EOG48GW2W.
PhylomeDB	Q4V8A3.
Gene expression databases
ArrayExpress	Q4V8A3.
Genevestigator	Q4V8A3.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K08825.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	653596.

Entry information

Entry name

DYRK3_RAT

Accession

Primary (citable) accession number: Q4V8A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	July 5, 2005
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program