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Protein

Sorting nexin-15

Gene

Snx15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Phosphatidylinositol 3-phosphateBy similarity
Binding sitei54 – 541Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei88 – 881Phosphatidylinositol 3-phosphateBy similarity
Binding sitei97 – 971Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:Snx15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305803. Snx15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Sorting nexin-15PRO_0000236203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V896.
PRIDEiQ4V896.

Expressioni

Gene expression databases

GenevisibleiQ4V896. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with SNX1, SNX2 and SNX4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028511.

Structurei

3D structure databases

ProteinModelPortaliQ4V896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 131131PXPROSITE-ProRule annotationAdd
BLAST
Domaini266 – 33873MITAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 MIT domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ4V896.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG7B31NH.
PhylomeDBiQ4V896.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRAKKDDF LRHYTVSDPR THPKGYTEYK VTAQFISKKD PEDIKEVVVW
60 70 80 90 100
KRYSDFRKLH GDLAYTHRNL FRRLEEFPAF PRAQVFGRFE ASVIEERRKG
110 120 130 140 150
AEDLLRFTVP IPALNNSPQL KEFFRGGEVT RPSEVSRDLQ ILPPPLIPTP
160 170 180 190 200
PSDEARLLQP LPAERRGQEE LEVPVDPLPS SPAQEALDLL FCCDSTEEAS
210 220 230 240 250
SSPARGPLSE AELALFDPYS KEESTGPSPT HTSELAAMEV QSKRLDQEPW
260 270 280 290 300
EPGGREEEEA EDGDPAPAYL GQATELITQA LRNEKAGAYA AALQGYQEGV
310 320 330
HILLQGVSGD PSPTRREGVK KKAAEYLKRA ETLHAHLP
Length:338
Mass (Da):37,905
Last modified:July 5, 2005 - v1
Checksum:i33EC50776634F83D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097481 mRNA. Translation: AAH97481.1.
RefSeqiNP_001019923.1. NM_001024752.1.
UniGeneiRn.104898.

Genome annotation databases

EnsembliENSRNOT00000028511; ENSRNOP00000028511; ENSRNOG00000021007.
GeneIDi293691.
KEGGirno:293691.
UCSCiRGD:1305803. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097481 mRNA. Translation: AAH97481.1.
RefSeqiNP_001019923.1. NM_001024752.1.
UniGeneiRn.104898.

3D structure databases

ProteinModelPortaliQ4V896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028511.

Proteomic databases

PaxDbiQ4V896.
PRIDEiQ4V896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028511; ENSRNOP00000028511; ENSRNOG00000021007.
GeneIDi293691.
KEGGirno:293691.
UCSCiRGD:1305803. rat.

Organism-specific databases

CTDi29907.
RGDi1305803. Snx15.

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ4V896.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG7B31NH.
PhylomeDBiQ4V896.
TreeFamiTF323964.

Miscellaneous databases

PROiQ4V896.

Gene expression databases

GenevisibleiQ4V896. RN.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiSNX15_RAT
AccessioniPrimary (citable) accession number: Q4V896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.