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Protein

Single Ig IL-1-related receptor

Gene

Sigirr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Single Ig IL-1-related receptor
Alternative name(s):
Single Ig IL-1R-related molecule
Single immunoglobulin domain-containing IL1R-related protein
Toll/interleukin-1 receptor 8
Short name:
TIR8
Gene namesi
Name:Sigirr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306732. Sigirr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 118ExtracellularSequence analysisAdd BLAST118
Transmembranei119 – 139Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini140 – 409CytoplasmicSequence analysisAdd BLAST270

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000990671 – 409Single Ig IL-1-related receptorAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi32 ↔ 97PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Modified residuei382PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4V892.
PRIDEiQ4V892.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015593.
GenevisibleiQ4V892. RN.

Interactioni

Subunit structurei

Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051758.

Structurei

3D structure databases

ProteinModelPortaliQ4V892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 109Ig-like C2-typeAdd BLAST101
Domaini163 – 310TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXB. Eukaryota.
ENOG410ZFDI. LUCA.
GeneTreeiENSGT00840000129987.
HOGENOMiHOG000237348.
HOVERGENiHBG080781.
InParanoidiQ4V892.
KOiK05169.
OMAiEVEMNDG.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ4V892.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVCDRVPN FLSPSEDQAL GPALGSAVAL NCTAWVFSRP QCPQPSVQWL
60 70 80 90 100
KDGLALGNGS HFSLHQDFWV SDNFSEIVSS VLVFNLTKAE DYGTFTCSAW
110 120 130 140 150
NVSSHSFTLW RAGPAGHVAA VLASLLVLVV LLLVALLYVK CRLNVLLWYQ
160 170 180 190 200
DTYGEVEMND GKLYDAYVSY SDRPEDRKFV NFILKPQLER RRGYKLFLED
210 220 230 240 250
RDLLPRAEPS ADLLVNLSRC RRLIVVLSDA FLRRPWCSQS FREGLCRLLE
260 270 280 290 300
LTRRPIFITF EGQRREPIHP ALRLLRQHRH LVTLLLWKPG SVTPSSDFWK
310 320 330 340 350
ELQLALPRKV QYRPVEGDPQ TRLQDDKDPM LIVRGRAAQG RAMESELDPD
360 370 380 390 400
PEGDLGVRGP VFGEPPTPLH ESKVSIGEGH ASEMDVSDLG SRNYSARTDF

YCLVSEDDV
Length:409
Mass (Da):46,171
Last modified:July 5, 2005 - v1
Checksum:i9BC31BF94AE43091
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097488 mRNA. Translation: AAH97488.1.
RefSeqiNP_001020058.1. NM_001024887.1.
XP_006230614.1. XM_006230552.3.
XP_006230615.1. XM_006230553.3.
XP_008758211.1. XM_008759989.2.
XP_008758212.1. XM_008759990.2.
XP_017444719.1. XM_017589230.1.
UniGeneiRn.16525.

Genome annotation databases

EnsembliENSRNOT00000054874; ENSRNOP00000051758; ENSRNOG00000015593.
GeneIDi309106.
KEGGirno:309106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097488 mRNA. Translation: AAH97488.1.
RefSeqiNP_001020058.1. NM_001024887.1.
XP_006230614.1. XM_006230552.3.
XP_006230615.1. XM_006230553.3.
XP_008758211.1. XM_008759989.2.
XP_008758212.1. XM_008759990.2.
XP_017444719.1. XM_017589230.1.
UniGeneiRn.16525.

3D structure databases

ProteinModelPortaliQ4V892.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051758.

Proteomic databases

PaxDbiQ4V892.
PRIDEiQ4V892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054874; ENSRNOP00000051758; ENSRNOG00000015593.
GeneIDi309106.
KEGGirno:309106.

Organism-specific databases

CTDi59307.
RGDi1306732. Sigirr.

Phylogenomic databases

eggNOGiENOG410IEXB. Eukaryota.
ENOG410ZFDI. LUCA.
GeneTreeiENSGT00840000129987.
HOGENOMiHOG000237348.
HOVERGENiHBG080781.
InParanoidiQ4V892.
KOiK05169.
OMAiEVEMNDG.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ4V892.
TreeFamiTF325519.

Miscellaneous databases

PROiQ4V892.

Gene expression databases

BgeeiENSRNOG00000015593.
GenevisibleiQ4V892. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIGIR_RAT
AccessioniPrimary (citable) accession number: Q4V892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.