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Protein

Protein fem-1 homolog A

Gene

Fem1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Gene namesi
Name:Fem1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1561112. Fem1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Protein fem-1 homolog APRO_0000324528Add
BLAST

Proteomic databases

PaxDbiQ4V890.
PRIDEiQ4V890.

PTM databases

iPTMnetiQ4V890.
PhosphoSiteiQ4V890.

Expressioni

Gene expression databases

GenevisibleiQ4V890. RN.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex. Interacts with PTGER4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067295.

Structurei

3D structure databases

ProteinModelPortaliQ4V890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14531ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati182 – 21130ANK 6Add
BLAST
Repeati214 – 24330ANK 7Add
BLAST
Repeati283 – 31735TPR 1Add
BLAST
Repeati375 – 40834TPR 2Add
BLAST
Repeati519 – 56143ANK 8Add
BLAST
Repeati565 – 59430ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOVERGENiHBG057774.
InParanoidiQ4V890.
OMAiCNARMER.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ4V890.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF48452. SSF48452. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLHTAVYNA AHDGKLLLLQ KLLAGRGREE IEELLGEVAG GGTPLLIAAR
60 70 80 90 100
RGHLDVVEYL VDNCGASVEA SGSVHFDGET IEGAPPLWAA SAAGHLAVVR
110 120 130 140 150
SLLRRGASVN RTTRTNSTPL RAACFDGHLD VVRYLVGEHK ADLEVANRHG
160 170 180 190 200
HTCLMISCYK GHREIARYLL ERGAQVNRRS AKGNTALHDC AESGSLEILQ
210 220 230 240 250
LLLGCHARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG HGQLSGTELP
260 270 280 290 300
GEGSSQMAGN HCSTPEEAEP YESCCPTSRE AAVEALELLG ATYVDKKRDL
310 320 330 340 350
LGALKHWRRA MELRHQGGDY LPKPEPQQLV LAYDYSREVS TPQELEALIT
360 370 380 390 400
DPDEMRMQAL LIRERILGPS HPDTSYYIRY RGAVYADSGN FERCIRLWKY
410 420 430 440 450
ALDMQQNNLE PLSPMTASSF LSFAELFSYV LQDRSAKGNL GMQLGFADLM
460 470 480 490 500
GVLSKGVREV ERALQLPKEP GDSAQFTKAI AIILHLLYLL EKVECTPSQE
510 520 530 540 550
HLKHQTVYRL LKCAPRGKNG FTPLHMAVDK ETTNVGRYRV GIFPSLQVVK
560 570 580 590 600
VLLDCGADPD SRDFDNNTPL HVAAQNNCPA IMDALIEAGA HMDATNAFKK
610 620 630 640 650
TAYELLDSKL LAKSTMQPFN YVTLQCLAAR ALDRNKVPYK GFIPEELEAF

IQLH
Length:654
Mass (Da):72,118
Last modified:July 5, 2005 - v1
Checksum:iDE3BFC58447C37C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097490 mRNA. Translation: AAH97490.1.
RefSeqiNP_001020877.1. NM_001025706.1.
UniGeneiRn.228392.

Genome annotation databases

EnsembliENSRNOT00000072771; ENSRNOP00000067295; ENSRNOG00000050646.
GeneIDi316131.
KEGGirno:316131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097490 mRNA. Translation: AAH97490.1.
RefSeqiNP_001020877.1. NM_001025706.1.
UniGeneiRn.228392.

3D structure databases

ProteinModelPortaliQ4V890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067295.

PTM databases

iPTMnetiQ4V890.
PhosphoSiteiQ4V890.

Proteomic databases

PaxDbiQ4V890.
PRIDEiQ4V890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072771; ENSRNOP00000067295; ENSRNOG00000050646.
GeneIDi316131.
KEGGirno:316131.

Organism-specific databases

CTDi55527.
RGDi1561112. Fem1a.

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOVERGENiHBG057774.
InParanoidiQ4V890.
OMAiCNARMER.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ4V890.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ4V890.

Gene expression databases

GenevisibleiQ4V890. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF48452. SSF48452. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiFEM1A_RAT
AccessioniPrimary (citable) accession number: Q4V890
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.