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Protein

Zinc transporter ZIP6

Gene

Slc39a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-RNO-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP6
Alternative name(s):
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name:
ZIP-6
Gene namesi
Name:Slc39a6Imported
Synonyms:Zip6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1304664. Slc39a6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 311291ExtracellularSequence analysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini333 – 3419CytoplasmicSequence analysis
Transmembranei342 – 36221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini363 – 40947ExtracellularSequence analysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini431 – 643213CytoplasmicSequence analysisAdd
BLAST
Transmembranei644 – 66421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini665 – 6728ExtracellularSequence analysis
Transmembranei673 – 69321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini694 – 71017CytoplasmicSequence analysisAdd
BLAST
Transmembranei711 – 73121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini732 – 74110ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 741721Zinc transporter ZIP6PRO_0000278127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis
Modified residuei464 – 4641PhosphoserineCombined sources
Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ4V887.
PRIDEiQ4V887.

PTM databases

PhosphoSiteiQ4V887.

Expressioni

Gene expression databases

GenevisibleiQ4V887. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034256.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili450 – 47526Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 11726His-richSequence analysisAdd
BLAST
Compositional biasi434 – 4396Poly-LysSequence analysis
Compositional biasi499 – 5024Poly-GluSequence analysis
Compositional biasi527 – 56438His-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]Sequence analysis

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ4V887.
KOiK14712.
OMAiSQGKGSH.
OrthoDBiEOG7H791W.
PhylomeDBiQ4V887.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNLSVIMI LTFALWVTNP LHELQSTAAF SQTTEKINSN WESGINVDVA
60 70 80 90 100
VTMQRHHLQQ LFYRYGENDS LSVEGFRKLL QNIGIDKIKR VHIHHDHERH
110 120 130 140 150
SDHERHSDHE RHSHRGHAAA GKNSRKAFCP DLDSDNSGKN PNTSQGKGSR
160 170 180 190 200
PAEHVNGRRN GKESASSSEV TSAVYNTVSE GTHFLETIET PKPGRRTKDI
210 220 230 240 250
NPSTPPSITE KSRVGRLSRL ARRKGNDSVS EPRKSFMYSR TSNDNIQECF
260 270 280 290 300
NATKLLTSHG MSVQALLNAT EFNYLCPAII NQIDARSCLI HTASEKKAEI
310 320 330 340 350
PPKTYSLQIA WLGGFIAISI ISFLSLLGVI LVPLMNRVFF KFLLSFLVAL
360 370 380 390 400
AVGTLSGDAL LHLLPHSHAS HHHSHSHEEP AMEMKRGPLF SHLSAQNLEE
410 420 430 440 450
SSYFDSTWKG LTALGGLYFM FLVEHVLTLI KQFKDKKKKN QKKPENDEDV
460 470 480 490 500
ESKKQLSKYE SQLSTNEEKV DTGERPESYL QADSQEPSPF DSQQPTLLEE
510 520 530 540 550
EEVMIAHAHP QEVYNEYVPR GCKNKCHSHF HDTLGQSDDL IHHHHDYHHI
560 570 580 590 600
LHHHHHQNHH PHSHSQRYSR EELKDAGIAT LAWMVIMGDG LHNFSDGLAI
610 620 630 640 650
GAAFTEGLSS GLSTSVAVFC HELPHELGDF AVLLKAGMTV KQAVLYNALS
660 670 680 690 700
AMLAYLGMAT GIFIGHYAEN VSMWIFALTA GLFMYVALVD MVPEMLHNDA
710 720 730 740
SDHGCSRWGY FFLQNAGILL GFGIMLLISI FEHKIVFRIN F
Length:741
Mass (Da):83,231
Last modified:July 5, 2005 - v1
Checksum:i1110AB62B640D500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097493 mRNA. Translation: AAH97493.1.
RefSeqiNP_001019916.1. NM_001024745.1.
UniGeneiRn.99415.

Genome annotation databases

EnsembliENSRNOT00000036306; ENSRNOP00000034256; ENSRNOG00000028703.
ENSRNOT00000079381; ENSRNOP00000075595; ENSRNOG00000028703.
GeneIDi291733.
KEGGirno:291733.
UCSCiRGD:1304664. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097493 mRNA. Translation: AAH97493.1.
RefSeqiNP_001019916.1. NM_001024745.1.
UniGeneiRn.99415.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034256.

PTM databases

PhosphoSiteiQ4V887.

Proteomic databases

PaxDbiQ4V887.
PRIDEiQ4V887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036306; ENSRNOP00000034256; ENSRNOG00000028703.
ENSRNOT00000079381; ENSRNOP00000075595; ENSRNOG00000028703.
GeneIDi291733.
KEGGirno:291733.
UCSCiRGD:1304664. rat.

Organism-specific databases

CTDi25800.
RGDi1304664. Slc39a6.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ4V887.
KOiK14712.
OMAiSQGKGSH.
OrthoDBiEOG7H791W.
PhylomeDBiQ4V887.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-RNO-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

NextBioi633074.
PROiQ4V887.

Gene expression databases

GenevisibleiQ4V887. RN.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS39A6_RAT
AccessioniPrimary (citable) accession number: Q4V887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: February 17, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.