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Protein

Collectin-12

Gene

Colec12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi644Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi646Calcium 1By similarity1
Metal bindingi650Calcium 1By similarity1
Metal bindingi670Calcium 2By similarity1
Metal bindingi674Calcium 2By similarity1
Binding sitei691CarbohydrateBy similarity1
Metal bindingi694Calcium 3By similarity1
Binding sitei694CarbohydrateBy similarity1
Metal bindingi696Calcium 3By similarity1
Binding sitei696CarbohydrateBy similarity1
Metal bindingi697Calcium 2By similarity1
Metal bindingi706Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi706Calcium 3By similarity1
Binding sitei706CarbohydrateBy similarity1
Metal bindingi707Calcium 2By similarity1
Metal bindingi718Calcium 3By similarity1
Binding sitei718CarbohydrateBy similarity1
Metal bindingi719Calcium 3By similarity1
Binding sitei719Carbohydrate; via carbonyl oxygenBy similarity1
Metal bindingi731Calcium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Collectin-12
Alternative name(s):
Collectin placenta protein 1
Short name:
CL-P1
Nurse cell scavenger receptor 2
Gene namesi
Name:Colec12
Synonyms:Clp1, Nsr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi735039. Colec12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 742ExtracellularSequence analysisAdd BLAST684

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003186831 – 742Collectin-12Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi607 ↔ 618PROSITE-ProRule annotation
Disulfide bondi635 ↔ 730PROSITE-ProRule annotation
Disulfide bondi708 ↔ 722PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4V885.
PRIDEiQ4V885.

Expressioni

Tissue specificityi

Highly expressed in lung, spleen, small and large intestine, stomach and brain. Expressed in neonatal microglia.1 Publication

Gene expression databases

BgeeiENSRNOG00000016366.
GenevisibleiQ4V885. RN.

Interactioni

Subunit structurei

The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar amyloid-beta peptide (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059663.

Structurei

3D structure databases

ProteinModelPortaliQ4V885.
SMRiQ4V885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini452 – 511Collagen-like 1Add BLAST60
Domaini527 – 586Collagen-like 2Add BLAST60
Domaini614 – 731C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 142Sequence analysisAdd BLAST39
Coiled coili220 – 301Sequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 10Poly-Glu4

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIUI. Eukaryota.
ENOG41101BT. LUCA.
GeneTreeiENSGT00820000126981.
HOGENOMiHOG000111886.
HOVERGENiHBG107745.
InParanoidiQ4V885.
KOiK10062.
OMAiTQCTKCK.
OrthoDBiEOG091G0OLC.
PhylomeDBiQ4V885.
TreeFamiTF332426.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di2.160.20.50. 3 hits.
3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR008160. Collagen.
IPR016187. CTDL_fold.
IPR016133. Insect_cyst_antifreeze_prot.
PfamiView protein in Pfam
PF01391. Collagen. 3 hits.
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDDFAEEEE VQSFGYKRFG IQEGTQCTKC KNNWALKFSI ILLYVLCALL
60 70 80 90 100
TITVAILGYK VVEKMDTVTD GMETSRQTYD NKLIAVESDL KKLGDQTGKK
110 120 130 140 150
ALSTNSELST FRSDILDLRQ QLQEITEKTS KNKDMLEKLQ ANGDSLVDRQ
160 170 180 190 200
SQLKETLQNN SFLITTVNKT LQAYNGYVTN LQQDTSVLQG NLQSQMYSQN
210 220 230 240 250
VVIMNLNNLN LTQVQQRNLI TNLQRSVDDT SLAIQQIKND FQNLQQVFLQ
260 270 280 290 300
AKKDTDWLKE KVQSLQTLAA NNSALAKANN DTLEDMNNQL SSFTGQMDNI
310 320 330 340 350
TTISQANEQS MKDLQDLHKD TENRTAVKFS QLEERFQVFE TDIVNIINNI
360 370 380 390 400
SYTAHHLRTL TSNLNDVRTT CTDTLTRHTD DLTSLNNTLV NIRLDSISLR
410 420 430 440 450
MQQDMMRSRL DTEVANLSVV MEEMKLVDSK HGQLIKNFTI LQGPPGPRGP
460 470 480 490 500
KGDRGSQGPP GPTGNKGQKG EKGEPGPPGP AGERGTIGPV GPPGERGSKG
510 520 530 540 550
SKGSQGPKGS RGSPGKPGPQ GPSGDPGPPG PPGKDGLPGP QGPPGFQGLQ
560 570 580 590 600
GTVGEPGVPG PRGLPGLPGV PGMPGPKGPP GPPGPSGAME PLALQNEPTP
610 620 630 640 650
ASEVNGCPPH WKNFTDKCYY FSVEKEIFED AKLFCEDKSS HLVFINSREE
660 670 680 690 700
QQWIKKQTMG RESHWIGLTD SEQESEWKWL DGTPVDYKNW KAGQPDNWGS
710 720 730 740
GHGPGEDCAG LIYAGQWNDF QCDEINNFIC EKEREAVPSS IL
Length:742
Mass (Da):81,546
Last modified:July 5, 2005 - v1
Checksum:iB1EB2768DB1C39F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248F → S in BAD06456 (PubMed:16868960).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097495 mRNA. Translation: AAH97495.1.
AB080968 mRNA. Translation: BAD06456.1.
RefSeqiNP_001020892.1. NM_001025721.1.
UniGeneiRn.31273.

Genome annotation databases

EnsembliENSRNOT00000065494; ENSRNOP00000059663; ENSRNOG00000016366.
GeneIDi361289.
KEGGirno:361289.
UCSCiRGD:735039. rat.

Similar proteinsi

Entry informationi

Entry nameiCOL12_RAT
AccessioniPrimary (citable) accession number: Q4V885
Secondary accession number(s): Q76LC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2005
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome