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Protein

Epsin-3

Gene

Epn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei11Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei25Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei30Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei63Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei73Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epsin-3
Alternative name(s):
EPS-15-interacting protein 3
Gene namesi
Name:Epn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306416. Epn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121781 – 608Epsin-3Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V882.
PRIDEiQ4V882.

PTM databases

iPTMnetiQ4V882.
PhosphoSitePlusiQ4V882.

Expressioni

Inductioni

In keratinocytes, by wounding or contact with collagen.

Gene expression databases

BgeeiENSRNOG00000003284.
GenevisibleiQ4V882. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004400.

Structurei

3D structure databases

ProteinModelPortaliQ4V882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 144ENTHPROSITE-ProRule annotationAdd BLAST133
Domaini202 – 221UIMPROSITE-ProRule annotationAdd BLAST20
Repeati287 – 28913
Repeati310 – 31223
Repeati337 – 33933
Repeati353 – 35543
Repeati370 – 37253
Repeati495 – 49713
Repeati508 – 51023
Repeati605 – 60733

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 3725 X 3 AA repeats of [DE]-P-WAdd BLAST86
Regioni495 – 6073 X 3 AA repeats of N-P-FAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi275 – 600Pro-richAdd BLAST326

Sequence similaritiesi

Belongs to the epsin family.Curated
Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2056. Eukaryota.
ENOG410XSM0. LUCA.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
HOVERGENiHBG006690.
InParanoidiQ4V882.
KOiK12471.
OMAiADPWSPI.
OrthoDBiEOG091G0L45.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR027318. Epsin-3_metazoa.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR12276:SF16. PTHR12276:SF16. 1 hit.
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT
60 70 80 90 100
VAFAEVMGMV WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL
110 120 130 140 150
YTIQTLKDFQ YIDRDGKDQG VNVREKVKQV MALLKDEERL RQERTHALKT
160 170 180 190 200
KERMALEGMG IGSGQLGFSR RSRGSPSSYT SASSSPRYAS DLEQARPQTS
210 220 230 240 250
GEEELQLQLA LAMSREEAEK GGRSWKGDDF PVANGAEPAG QRRRDREPER
260 270 280 290 300
EERKEEEKLK TSQSSILDLA DVFAPAPALP STHCSADPWD IPGLRPNTEP
310 320 330 340 350
SGSSWGPSAD PWSPVPSGNA LSRSQPWDLL PTLSSSEPWG RTPVLPSGPP
360 370 380 390 400
ITDPWAPSSP TPKLPSTGVD PWGASVETSN TSALGGASPF DPFAKPLEST
410 420 430 440 450
EPMESRDSAQ ALPKGKSPSP VELDPFGDSS PSCKQNGVKE TEALDLGVLG
460 470 480 490 500
EALTQQPGKE ARPCRTPESF LGPSASSLVN LDSLVKAPLA ARTRNPFLTG
510 520 530 540 550
LSAPSPTNPF GAGEQGRPTL NQMRTGSPAL GLPPGGPVGV PLGSMTYSAS
560 570 580 590 600
LPLPLSSVPV GATLPASVSV FPQAGAFAPP PASLPQPLLP TSDPVGPLPP

QAGTNPFL
Length:608
Mass (Da):65,048
Last modified:July 5, 2005 - v1
Checksum:i396354172B39C504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097500 mRNA. Translation: AAH97500.1.
RefSeqiNP_001019962.1. NM_001024791.1.
XP_006247265.1. XM_006247203.3.
UniGeneiRn.26582.

Genome annotation databases

EnsembliENSRNOT00000004400; ENSRNOP00000004400; ENSRNOG00000003284.
GeneIDi360605.
KEGGirno:360605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097500 mRNA. Translation: AAH97500.1.
RefSeqiNP_001019962.1. NM_001024791.1.
XP_006247265.1. XM_006247203.3.
UniGeneiRn.26582.

3D structure databases

ProteinModelPortaliQ4V882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004400.

PTM databases

iPTMnetiQ4V882.
PhosphoSitePlusiQ4V882.

Proteomic databases

PaxDbiQ4V882.
PRIDEiQ4V882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004400; ENSRNOP00000004400; ENSRNOG00000003284.
GeneIDi360605.
KEGGirno:360605.

Organism-specific databases

CTDi55040.
RGDi1306416. Epn3.

Phylogenomic databases

eggNOGiKOG2056. Eukaryota.
ENOG410XSM0. LUCA.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
HOVERGENiHBG006690.
InParanoidiQ4V882.
KOiK12471.
OMAiADPWSPI.
OrthoDBiEOG091G0L45.

Miscellaneous databases

PROiQ4V882.

Gene expression databases

BgeeiENSRNOG00000003284.
GenevisibleiQ4V882. RN.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR027318. Epsin-3_metazoa.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR12276:SF16. PTHR12276:SF16. 1 hit.
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPN3_RAT
AccessioniPrimary (citable) accession number: Q4V882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.