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Q4V862 (CDK9A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 9-A
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division protein kinase 9-A
Gene names
Name:cdk9-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subunit structure

Associates with cyclin-T to form P-TEFb By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Cyclin-dependent kinase 9-A
PRO_0000085804

Regions

Domain19 – 319301Protein kinase
Nucleotide binding25 – 339ATP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4V862 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: E8F9268980E052F6

FASTA37643,224
        10         20         30         40         50         60 
MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 

        70         80         90        100        110        120 
ITALREIKIL QLLKHENVVN LIEICRTKVS PTANQYNRCK GTIFLVFDFC EHDLAGLLSN 

       130        140        150        160        170        180 
AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL 

       190        200        210        220        230        240 
AKNSQPNKYT NRVVTLWYRP PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH 

       250        260        270        280        290        300 
QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK DRLKAYVKDP HALDLIDKLL 

       310        320        330        340        350        360 
VLDPTQRLDS DDALNNDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG GHMPQQPANQ 

       370 
ARNPAATNQS EFERVF

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC097527 mRNA. Translation: AAH97527.1.
RefSeqNP_001090029.1. NM_001096560.1.
UniGeneXl.16809.

3D structure databases

ProteinModelPortalQ4V862.
SMRQ4V862. Positions 7-329.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID735101.
KEGGxla:735101.

Organism-specific databases

CTD735101.
XenbaseXB-GENE-483725. cdk9.

Phylogenomic databases

HOVERGENHBG014652.
KOK02211.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK9A_XENLA
AccessionPrimary (citable) accession number: Q4V862
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2005
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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