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Protein

GPI mannosyltransferase 3

Gene

pigb

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:pigb
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-996683. pigb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19623HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531GPI mannosyltransferase 3PRO_0000246254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence analysis
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG082136.
KOiK05286.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V7R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVRSRVGW LYRRQDSQGA VQLRKRKSRL YSKEASSACP GAGLFGENTY
60 70 80 90 100
LVLAAVGFRI FNCMMVQTSF VPDEYWQSLE VAHNMTFNYG YLTWEWTEGL
110 120 130 140 150
RGFSYPLMFA AIYKVLYLLG KDHVWFLIWI PRLAQAVLSG IADVRLYSLV
160 170 180 190 200
RHLENTELAK WVYFCQLCSW FTWYCATRTL TNTMEAVLST FALYYYPLEG
210 220 230 240 250
SSTNSSTKYL ICVALAFLIR PTAVILWIPL LFYHFAKEKK KAELVVQQYL
260 270 280 290 300
PIGILTLAAS LTVDRIFFGK WTFVQWNFLK FNVLQDLGSF YGSHPWHWYI
310 320 330 340 350
TQGVPVILCT HLPFFIHGCM VTPKRYQILL VAVAWTVLTY SALSHKEFRF
360 370 380 390 400
IYPVLPVCMV FCGFSFSNLK RWKKAAVGFL VLSNLFPALY TGLIHQRGAL
410 420 430 440 450
DIMSGIQKLC KMENSSASLF VLMPCHSIPF YSHVHCPIKM NFLECPPDLS
460 470 480 490 500
DSDAYIDEAD LFYVSPLAWL NAEFYNKTLL PTHLIMFSVL EPEIRSFLTN
510 520 530
NNYLKSMSVF HTHLPEGRTG SHIYMYERNS K
Length:531
Mass (Da):61,447
Last modified:July 5, 2005 - v1
Checksum:i17F0EAF486BC0C81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097762 mRNA. Translation: AAH97762.1.
RefSeqiNP_001089512.1. NM_001096043.1.
UniGeneiXl.37872.

Genome annotation databases

GeneIDi734564.
KEGGixla:734564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097762 mRNA. Translation: AAH97762.1.
RefSeqiNP_001089512.1. NM_001096043.1.
UniGeneiXl.37872.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi734564.
KEGGixla:734564.

Organism-specific databases

CTDi9488.
XenbaseiXB-GENE-996683. pigb.

Phylogenomic databases

HOVERGENiHBG082136.
KOiK05286.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGB_XENLA
AccessioniPrimary (citable) accession number: Q4V7R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.