Reviewed, UniProtKB/Swiss-Prot Q4V7R0 (TIGAR_XENLA)

Names and origin

Protein names

Recommended name:
    Probable fructose-2,6-bisphosphatase TIGAR
    EC=3.1.3.46
Alternative name(s):
    TP53-induced glycolysis and apoptosis regulator

Gene names

Name:

tigar

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by tp53 By similarity.
Catalytic activity	Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
Sequence similarities	Belongs to the phosphoglycerate mutase family.
Caution	Not expected to have any kinase activity.

Ontologies

Keywords
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	fructose-2,6-bisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Probable fructose-2,6-bisphosphatase TIGAR		PRO_0000363069
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4V7R0-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 95DF4520AEF1C924	FASTA	275	30,658
	10 20 30 40 50 60 MARFALTIVR HGETRYNKEK LLQGQGIDEP LSEMGFKQAD AAGRFLSNVR FTHVFSSDLI 70 80 90 100 110 120 RAKQTACAIM RNNQLSEDIK IMYDPRLRER KYGDAEGRPL SELKVMAKKA GGQCPSYTPP 130 140 150 160 170 180 GGETLEQVRA CAKDFFEYLC QLVMAESSVK EKSELGASGM VGIMSTDLAP FVNHNKEPTI 190 200 210 220 230 240 FGESRDVTLD ASVLLVSHGA YMRNWIKYFV EDLQFTFPPE LKKSRELSVS PNTGISHFIV 250 260 270 TVGSGATRKP EIQCVCINLH GHLSDIDADT SHYQV

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Egg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097765 mRNA. Translation: AAH97765.1.
RefSeq	NP_001089513.1.
UniGene	Xl.54011
3D structure databases
SMR	Q4V7R0. Positions 1-210, 5-263.
ModBase	Search...
Genome annotation databases
GeneID	734566.
KEGG	xla:734566.
Organism-specific databases
CTD	734566.
Xenbase	XB-FEAT-1008471. c12orf5.
Phylogenomic databases
HOVERGEN	Q4V7R0.
Family and domain databases
InterPro	IPR001345. PG/BPGM_mutase_AS. IPR013078. PG_mutase. [Graphical view]
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIGAR_XENLA

Accession

Primary (citable) accession number: Q4V7R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 5, 2005
Last modified:	January 19, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project