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Protein

PIH1 domain-containing protein 1

Gene

Pih1d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interacts with TELO2By similarity1
Sitei64Interacts with TELO2By similarity1
Sitei113Interacts with TELO2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
PIH1 domain-containing protein 1
Gene namesi
Name:Pih1d1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309809. Pih1d1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073301 – 290PIH1 domain-containing protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei173PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V7F5.
PRIDEiQ4V7F5.

PTM databases

iPTMnetiQ4V7F5.
PhosphoSitePlusiQ4V7F5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020634.
GenevisibleiQ4V7F5. RN.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3. Interacts with phosphorylated TELO2 and mediates interaction of TELO2 with the R2TP complex. Interacts with phosphorylated ECD, EFTUD2/SNRP116, RPB1 and UBR5 and with RPB1 in a phosphorylation-independent manner. Interacts with the core C/D box snoRNP particle components NOP58 and FBL and with RUVBL1/TIP49. Interacts with RPAP3 and WDR92. Interacts with histone H4 and with SWI/SNF complex member SMARCB1/SNF5. Interacts with the mTORC1 complex member RPTOR.By similarity

Protein-protein interaction databases

IntActiQ4V7F5. 1 interactor.
STRINGi10116.ENSRNOP00000028022.

Family & Domainsi

Domaini

The N-terminal region is required for binding to phosphorylated substrates while the C-terminal region binds to the other R2TP complex components.By similarity

Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

eggNOGiKOG4356. Eukaryota.
ENOG410XQ8C. LUCA.
GeneTreeiENSGT00510000048192.
HOGENOMiHOG000067888.
HOVERGENiHBG108251.
InParanoidiQ4V7F5.
OMAiLDIFLPY.
OrthoDBiEOG091G0I5K.
PhylomeDBiQ4V7F5.
TreeFamiTF324376.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V7F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKLLAPE LSDAESMGEE TVRFQELLLK ASKELQQAQT ARPESTQIQP
60 70 80 90 100
KPGFCIKTNS SEGKVFINIC HSPSIPPPVD VTEDELLQML EEDQAGFRIP
110 120 130 140 150
MSLGEPHAEL DAKGQGCTAY DVAVNSNFYL RMQNSDFLRE LVVTIAREGL
160 170 180 190 200
EDKYGLQLNP EWRMLKYRSF LGSISQQSIR SQQRPRIQEL GTLDTHDSLG
210 220 230 240 250
TRHGPERPHL NLWLEAPDLL LAEVDLPKLD GAQGLALEIG ENRLVVGGPQ
260 270 280 290
QLYHLDACIP LRINSEASRA AFHHRRKQLM VSMPLLSASS
Length:290
Mass (Da):32,361
Last modified:July 5, 2005 - v1
Checksum:i8BC897FEC041D4C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097946 mRNA. Translation: AAH97946.1.
RefSeqiNP_001020039.1. NM_001024868.1.
XP_006229089.1. XM_006229027.2.
XP_006229090.1. XM_006229028.3.
UniGeneiRn.155172.

Genome annotation databases

EnsembliENSRNOT00000028022; ENSRNOP00000028022; ENSRNOG00000020634.
GeneIDi292898.
KEGGirno:292898.
UCSCiRGD:1309809. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097946 mRNA. Translation: AAH97946.1.
RefSeqiNP_001020039.1. NM_001024868.1.
XP_006229089.1. XM_006229027.2.
XP_006229090.1. XM_006229028.3.
UniGeneiRn.155172.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4V7F5. 1 interactor.
STRINGi10116.ENSRNOP00000028022.

PTM databases

iPTMnetiQ4V7F5.
PhosphoSitePlusiQ4V7F5.

Proteomic databases

PaxDbiQ4V7F5.
PRIDEiQ4V7F5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028022; ENSRNOP00000028022; ENSRNOG00000020634.
GeneIDi292898.
KEGGirno:292898.
UCSCiRGD:1309809. rat.

Organism-specific databases

CTDi55011.
RGDi1309809. Pih1d1.

Phylogenomic databases

eggNOGiKOG4356. Eukaryota.
ENOG410XQ8C. LUCA.
GeneTreeiENSGT00510000048192.
HOGENOMiHOG000067888.
HOVERGENiHBG108251.
InParanoidiQ4V7F5.
OMAiLDIFLPY.
OrthoDBiEOG091G0I5K.
PhylomeDBiQ4V7F5.
TreeFamiTF324376.

Miscellaneous databases

PROiQ4V7F5.

Gene expression databases

BgeeiENSRNOG00000020634.
GenevisibleiQ4V7F5. RN.

Family and domain databases

InterProiIPR012981. PIH1.
[Graphical view]
PANTHERiPTHR22997. PTHR22997. 1 hit.
PfamiPF08190. PIH1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIHD1_RAT
AccessioniPrimary (citable) accession number: Q4V7F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.