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Protein

PIH1 domain-containing protein 1

Gene

Pih1d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interacts with TELO2By similarity1
Sitei64Interacts with TELO2By similarity1
Sitei113Interacts with TELO2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
PIH1 domain-containing protein 1
Gene namesi
Name:Pih1d1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309809 Pih1d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073301 – 290PIH1 domain-containing protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei173PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V7F5
PRIDEiQ4V7F5

PTM databases

iPTMnetiQ4V7F5
PhosphoSitePlusiQ4V7F5

Expressioni

Gene expression databases

BgeeiENSRNOG00000020634
GenevisibleiQ4V7F5 RN

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3. Interacts with phosphorylated TELO2 and mediates interaction of TELO2 with the R2TP complex. Interacts with phosphorylated ECD, EFTUD2/SNRP116, RPB1 and UBR5 and with RPB1 in a phosphorylation-independent manner. Interacts with the core C/D box snoRNP particle components NOP58 and FBL and with RUVBL1/TIP49. Interacts with RPAP3 and WDR92. Interacts with histone H4 and with SWI/SNF complex member SMARCB1/SNF5. Interacts with the mTORC1 complex member RPTOR.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ4V7F5, 1 interactor
MINTiQ4V7F5
STRINGi10116.ENSRNOP00000028022

Structurei

3D structure databases

SMRiQ4V7F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal region is required for binding to phosphorylated substrates while the C-terminal region binds to the other R2TP complex components.By similarity

Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

eggNOGiKOG4356 Eukaryota
ENOG410XQ8C LUCA
GeneTreeiENSGT00510000048192
HOGENOMiHOG000067888
HOVERGENiHBG108251
InParanoidiQ4V7F5
OMAiINQDFFQ
OrthoDBiEOG091G0I5K
PhylomeDBiQ4V7F5
TreeFamiTF324376

Family and domain databases

InterProiView protein in InterPro
IPR012981 PIH1_dom
PANTHERiPTHR22997 PTHR22997, 1 hit
PfamiView protein in Pfam
PF08190 PIH1, 2 hits

Sequencei

Sequence statusi: Complete.

Q4V7F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSKLLAPE LSDAESMGEE TVRFQELLLK ASKELQQAQT ARPESTQIQP
60 70 80 90 100
KPGFCIKTNS SEGKVFINIC HSPSIPPPVD VTEDELLQML EEDQAGFRIP
110 120 130 140 150
MSLGEPHAEL DAKGQGCTAY DVAVNSNFYL RMQNSDFLRE LVVTIAREGL
160 170 180 190 200
EDKYGLQLNP EWRMLKYRSF LGSISQQSIR SQQRPRIQEL GTLDTHDSLG
210 220 230 240 250
TRHGPERPHL NLWLEAPDLL LAEVDLPKLD GAQGLALEIG ENRLVVGGPQ
260 270 280 290
QLYHLDACIP LRINSEASRA AFHHRRKQLM VSMPLLSASS
Length:290
Mass (Da):32,361
Last modified:July 5, 2005 - v1
Checksum:i8BC897FEC041D4C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097946 mRNA Translation: AAH97946.1
RefSeqiNP_001020039.1, NM_001024868.1
XP_006229089.1, XM_006229027.2
XP_006229090.1, XM_006229028.3
UniGeneiRn.155172

Genome annotation databases

EnsembliENSRNOT00000028022; ENSRNOP00000028022; ENSRNOG00000020634
GeneIDi292898
KEGGirno:292898
UCSCiRGD:1309809 rat

Similar proteinsi

Entry informationi

Entry nameiPIHD1_RAT
AccessioniPrimary (citable) accession number: Q4V7F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health