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Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

Lrrfip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 2
Short name:
LRR FLII-interacting protein 2
Gene namesi
Name:Lrrfip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306234. Lrrfip2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Leucine-rich repeat flightless-interacting protein 2PRO_0000245248Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei114 – 1141PhosphoserineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei133 – 1331PhosphoserineCombined sources
Modified residuei136 – 1361PhosphothreonineBy similarity
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V7E8.
PRIDEiQ4V7E8.

PTM databases

iPTMnetiQ4V7E8.
PhosphoSiteiQ4V7E8.

Expressioni

Gene expression databases

GenevisibleiQ4V7E8. RN.

Interactioni

Subunit structurei

Interacts with DVL3 and FLII (By similarity). Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation. In the presence of LPS, competes with FLII for MYD88-binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi256809. 1 interaction.
STRINGi10116.ENSRNOP00000052912.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili22 – 4928Sequence analysisAdd
BLAST
Coiled coili143 – 23997Sequence analysisAdd
BLAST
Coiled coili282 – 430149Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2010. Eukaryota.
ENOG4111H1S. LUCA.
GeneTreeiENSGT00530000063564.
HOGENOMiHOG000294125.
HOVERGENiHBG061558.
InParanoidiQ4V7E8.
OMAiYKYKLQK.
OrthoDBiEOG7DNNTX.
PhylomeDBiQ4V7E8.
TreeFamiTF314109.

Family and domain databases

InterProiIPR019139. LRRFIP1/2.
[Graphical view]
PANTHERiPTHR19212. PTHR19212. 1 hit.
PfamiPF09738. DUF2051. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGSGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM
60 70 80 90 100
RELERQQRES SSKDITGTHW SRASTPKRRD MMYDSIKDRS SRVSSLLDEK
110 120 130 140 150
SDKQYAENYT RPSSRNSASA TTPLSGNSSR RGSGDTSSLI DPDTSLSELR
160 170 180 190 200
ESLSEVEEKY KKAMVSNAQL DNEKNNLIYQ VDTLKDVIEE QEEQMAEFYR
210 220 230 240 250
ENEEKSKELE RQKHMCSVLQ HKMDELKEGL RQRDELIEKH GLVIIPESTP
260 270 280 290 300
NGDVNHEPVV GAITAVSQEA AQVLESAGEG PLDVRLRKLA EEKDELLSQI
310 320 330 340 350
RKLKLQLEEE RQKCSRNDGM SGDLAGLQNG SDLQFIEMQR DANRQISEYK
360 370 380 390 400
FKLSKAEQDI ATLEQSISRL EGQVLRYKTA AENAEKIEDE LKAEKRKLQR
410 420 430
ELRTAQDKIE EMEMTNSHLA KRLEKMKANR TALLAQQ
Length:437
Mass (Da):49,773
Last modified:July 5, 2005 - v1
Checksum:i5D75A735B51CD4E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097955 mRNA. Translation: AAH97955.1.
RefSeqiNP_001019932.1. NM_001024761.1.
UniGeneiRn.20528.

Genome annotation databases

EnsembliENSRNOT00000056060; ENSRNOP00000052912; ENSRNOG00000021047.
GeneIDi301035.
KEGGirno:301035.
UCSCiRGD:1306234. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097955 mRNA. Translation: AAH97955.1.
RefSeqiNP_001019932.1. NM_001024761.1.
UniGeneiRn.20528.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256809. 1 interaction.
STRINGi10116.ENSRNOP00000052912.

PTM databases

iPTMnetiQ4V7E8.
PhosphoSiteiQ4V7E8.

Proteomic databases

PaxDbiQ4V7E8.
PRIDEiQ4V7E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056060; ENSRNOP00000052912; ENSRNOG00000021047.
GeneIDi301035.
KEGGirno:301035.
UCSCiRGD:1306234. rat.

Organism-specific databases

CTDi9209.
RGDi1306234. Lrrfip2.

Phylogenomic databases

eggNOGiKOG2010. Eukaryota.
ENOG4111H1S. LUCA.
GeneTreeiENSGT00530000063564.
HOGENOMiHOG000294125.
HOVERGENiHBG061558.
InParanoidiQ4V7E8.
OMAiYKYKLQK.
OrthoDBiEOG7DNNTX.
PhylomeDBiQ4V7E8.
TreeFamiTF314109.

Miscellaneous databases

PROiQ4V7E8.

Gene expression databases

GenevisibleiQ4V7E8. RN.

Family and domain databases

InterProiIPR019139. LRRFIP1/2.
[Graphical view]
PANTHERiPTHR19212. PTHR19212. 1 hit.
PfamiPF09738. DUF2051. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-125 AND SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLRRF2_RAT
AccessioniPrimary (citable) accession number: Q4V7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.