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Protein

Leucine-rich repeat flightless-interacting protein 2

Gene

Lrrfip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat flightless-interacting protein 2
Short name:
LRR FLII-interacting protein 2
Gene namesi
Name:Lrrfip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306234 Lrrfip2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452481 – 437Leucine-rich repeat flightless-interacting protein 2Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei114PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei129PhosphoserineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei136PhosphothreonineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V7E8
PRIDEiQ4V7E8

PTM databases

iPTMnetiQ4V7E8
PhosphoSitePlusiQ4V7E8

Expressioni

Gene expression databases

BgeeiENSRNOG00000021047
GenevisibleiQ4V7E8 RN

Interactioni

Subunit structurei

Interacts with DVL3 and FLII (By similarity). Weakly interacts with MYD88 in resting cells. Following LPS-stimulation, the interaction with MYD88 is rapidly enhanced; the complex gradually dissociates to basal levels after 6 hours of stimulation. Interaction with MYD88 is regulated by LPS-induced phosphorylation. In the presence of LPS, competes with FLII for MYD88-binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi256809, 1 interactor
IntActiQ4V7E8, 1 interactor
STRINGi10116.ENSRNOP00000052912

Structurei

3D structure databases

SMRiQ4V7E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 49Sequence analysisAdd BLAST28
Coiled coili143 – 239Sequence analysisAdd BLAST97
Coiled coili282 – 430Sequence analysisAdd BLAST149

Sequence similaritiesi

Belongs to the LRRFIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2010 Eukaryota
ENOG4111H1S LUCA
GeneTreeiENSGT00530000063564
HOGENOMiHOG000294125
HOVERGENiHBG061558
InParanoidiQ4V7E8
OMAiYKYKLQK
OrthoDBiEOG091G0C5Y
PhylomeDBiQ4V7E8
TreeFamiTF314109

Family and domain databases

InterProiView protein in InterPro
IPR019139 LRRFIP1/2
PANTHERiPTHR19212 PTHR19212, 3 hits
PfamiView protein in Pfam
PF09738 LRRFIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGSGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM
60 70 80 90 100
RELERQQRES SSKDITGTHW SRASTPKRRD MMYDSIKDRS SRVSSLLDEK
110 120 130 140 150
SDKQYAENYT RPSSRNSASA TTPLSGNSSR RGSGDTSSLI DPDTSLSELR
160 170 180 190 200
ESLSEVEEKY KKAMVSNAQL DNEKNNLIYQ VDTLKDVIEE QEEQMAEFYR
210 220 230 240 250
ENEEKSKELE RQKHMCSVLQ HKMDELKEGL RQRDELIEKH GLVIIPESTP
260 270 280 290 300
NGDVNHEPVV GAITAVSQEA AQVLESAGEG PLDVRLRKLA EEKDELLSQI
310 320 330 340 350
RKLKLQLEEE RQKCSRNDGM SGDLAGLQNG SDLQFIEMQR DANRQISEYK
360 370 380 390 400
FKLSKAEQDI ATLEQSISRL EGQVLRYKTA AENAEKIEDE LKAEKRKLQR
410 420 430
ELRTAQDKIE EMEMTNSHLA KRLEKMKANR TALLAQQ
Length:437
Mass (Da):49,773
Last modified:July 5, 2005 - v1
Checksum:i5D75A735B51CD4E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097955 mRNA Translation: AAH97955.1
RefSeqiNP_001019932.1, NM_001024761.1
UniGeneiRn.20528

Genome annotation databases

EnsembliENSRNOT00000056060; ENSRNOP00000052912; ENSRNOG00000021047
GeneIDi301035
KEGGirno:301035
UCSCiRGD:1306234 rat

Similar proteinsi

Entry informationi

Entry nameiLRRF2_RAT
AccessioniPrimary (citable) accession number: Q4V7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health