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Q4V7E6

- Q4V7E6_RAT

UniProt

Q4V7E6 - Q4V7E6_RAT

Protein
Submitted name:

Protein Wwtr1

Gene

Wwtr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transcription coactivator activity Source: Ensembl
    2. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. cilium morphogenesis Source: Ensembl
    2. glomerulus development Source: Ensembl
    3. hippo signaling Source: Ensembl
    4. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    5. negative regulation of catenin import into nucleus Source: Ensembl
    6. negative regulation of fat cell differentiation Source: Ensembl
    7. negative regulation of protein kinase activity Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. osteoblast differentiation Source: Ensembl
    10. positive regulation of cell proliferation Source: Ensembl
    11. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. regulation of SMAD protein import into nucleus Source: Ensembl
    14. stem cell division Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_194629. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_196408. PPARA activates gene expression.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198809. Signaling by Hippo.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Wwtr1Imported
    Submitted name:
    Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_bImported
    Submitted name:
    WW domain containing transcription regulator 1Imported
    Gene namesi
    Name:Wwtr1Imported
    Synonyms:MGC116096Imported
    ORF Names:rCG_50075Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1559609. Wwtr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI
    3. transcription factor complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ4V7E6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022507.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG247722.
    GeneTreeiENSGT00510000046760.
    HOGENOMiHOG000007854.
    HOVERGENiHBG002748.
    InParanoidiQ4V7E6.
    KOiK16820.
    OMAiHTGQRYF.
    OrthoDBiEOG75MVW6.
    TreeFamiTF326941.

    Family and domain databases

    InterProiIPR001202. WW_dom.
    [Graphical view]
    PfamiPF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4V7E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSSVPHPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE    50
    SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA 100
    GAAGGPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT 150
    TWQDPRKVMN QPLNHVNLHP TITSTSVPQR SMAVSQPNLA MNHQHQQVVA 200
    TSLSPQNHPA QNPPTGLMSV PNALTTQQQQ QQKLRLQRIQ MERERIRMRQ 250
    EELMRQEAAL CRQLPMETET MAPVNTPAMN TDMRSVTNSS SDPFLNGGPY 300
    HSREQSTDSG LGLGCYSVPT TPEDFLSNMD EMDTGENSGQ TPMTVNPQQT 350
    RFPDFLDCLP GTNVDLGTLE SEDLIPLFND VESALNKSEP FLTWL 395
    Length:395
    Mass (Da):43,600
    Last modified:July 5, 2005 - v1
    Checksum:i986707E910AC433B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06016822 Genomic DNA. No translation available.
    AABR06016823 Genomic DNA. No translation available.
    BC097968 mRNA. Translation: AAH97968.1.
    CH474003 Genomic DNA. Translation: EDM14889.1.
    CH474003 Genomic DNA. Translation: EDM14890.1.
    RefSeqiNP_001020040.1. NM_001024869.1.
    UniGeneiRn.9622.

    Genome annotation databases

    EnsembliENSRNOT00000022507; ENSRNOP00000022507; ENSRNOG00000016617.
    GeneIDi295062.
    KEGGirno:295062.
    UCSCiRGD:1559609. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06016822 Genomic DNA. No translation available.
    AABR06016823 Genomic DNA. No translation available.
    BC097968 mRNA. Translation: AAH97968.1 .
    CH474003 Genomic DNA. Translation: EDM14889.1 .
    CH474003 Genomic DNA. Translation: EDM14890.1 .
    RefSeqi NP_001020040.1. NM_001024869.1.
    UniGenei Rn.9622.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022507 ; ENSRNOP00000022507 ; ENSRNOG00000016617 .
    GeneIDi 295062.
    KEGGi rno:295062.
    UCSCi RGD:1559609. rat.

    Organism-specific databases

    CTDi 25937.
    RGDi 1559609. Wwtr1.

    Phylogenomic databases

    eggNOGi NOG247722.
    GeneTreei ENSGT00510000046760.
    HOGENOMi HOG000007854.
    HOVERGENi HBG002748.
    InParanoidi Q4V7E6.
    KOi K16820.
    OMAi HTGQRYF.
    OrthoDBi EOG75MVW6.
    TreeFami TF326941.

    Enzyme and pathway databases

    Reactomei REACT_194629. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_196408. PPARA activates gene expression.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_198809. Signaling by Hippo.

    Miscellaneous databases

    NextBioi 638920.
    PROi Q4V7E6.

    Gene expression databases

    Genevestigatori Q4V7E6.

    Family and domain databases

    InterProi IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ4V7E6_RAT
    AccessioniPrimary (citable) accession number: Q4V7E6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3