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Q4V7E6

- Q4V7E6_RAT

UniProt

Q4V7E6 - Q4V7E6_RAT

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Protein
Submitted name:

Protein Wwtr1

Gene

Wwtr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transcription coactivator activity Source: Ensembl
  2. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cilium morphogenesis Source: Ensembl
  2. glomerulus development Source: Ensembl
  3. hippo signaling Source: Ensembl
  4. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  5. negative regulation of catenin import into nucleus Source: Ensembl
  6. negative regulation of fat cell differentiation Source: Ensembl
  7. negative regulation of protein kinase activity Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. osteoblast differentiation Source: Ensembl
  10. positive regulation of cell proliferation Source: Ensembl
  11. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  14. regulation of SMAD protein import into nucleus Source: Ensembl
  15. stem cell division Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_194629. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_196408. PPARA activates gene expression.
REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198809. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Wwtr1Imported
Submitted name:
Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_bImported
Submitted name:
WW domain containing transcription regulator 1Imported
Gene namesi
Name:Wwtr1Imported
Synonyms:MGC116096Imported
ORF Names:rCG_50075Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1559609. Wwtr1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: MGI
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ4V7E6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022507.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG247722.
GeneTreeiENSGT00510000046760.
HOGENOMiHOG000007854.
HOVERGENiHBG002748.
KOiK16820.
OMAiHTGQRYF.
OrthoDBiEOG75MVW6.
TreeFamiTF326941.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V7E6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPSSVPHPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE
60 70 80 90 100
SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA
110 120 130 140 150
GAAGGPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT
160 170 180 190 200
TWQDPRKVMN QPLNHVNLHP TITSTSVPQR SMAVSQPNLA MNHQHQQVVA
210 220 230 240 250
TSLSPQNHPA QNPPTGLMSV PNALTTQQQQ QQKLRLQRIQ MERERIRMRQ
260 270 280 290 300
EELMRQEAAL CRQLPMETET MAPVNTPAMN TDMRSVTNSS SDPFLNGGPY
310 320 330 340 350
HSREQSTDSG LGLGCYSVPT TPEDFLSNMD EMDTGENSGQ TPMTVNPQQT
360 370 380 390
RFPDFLDCLP GTNVDLGTLE SEDLIPLFND VESALNKSEP FLTWL
Length:395
Mass (Da):43,600
Last modified:July 5, 2005 - v1
Checksum:i986707E910AC433B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06016822 Genomic DNA. No translation available.
AABR06016823 Genomic DNA. No translation available.
BC097968 mRNA. Translation: AAH97968.1.
CH474003 Genomic DNA. Translation: EDM14889.1.
CH474003 Genomic DNA. Translation: EDM14890.1.
RefSeqiNP_001020040.1. NM_001024869.1.
UniGeneiRn.9622.

Genome annotation databases

EnsembliENSRNOT00000022507; ENSRNOP00000022507; ENSRNOG00000016617.
GeneIDi295062.
KEGGirno:295062.
UCSCiRGD:1559609. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06016822 Genomic DNA. No translation available.
AABR06016823 Genomic DNA. No translation available.
BC097968 mRNA. Translation: AAH97968.1 .
CH474003 Genomic DNA. Translation: EDM14889.1 .
CH474003 Genomic DNA. Translation: EDM14890.1 .
RefSeqi NP_001020040.1. NM_001024869.1.
UniGenei Rn.9622.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022507 ; ENSRNOP00000022507 ; ENSRNOG00000016617 .
GeneIDi 295062.
KEGGi rno:295062.
UCSCi RGD:1559609. rat.

Organism-specific databases

CTDi 25937.
RGDi 1559609. Wwtr1.

Phylogenomic databases

eggNOGi NOG247722.
GeneTreei ENSGT00510000046760.
HOGENOMi HOG000007854.
HOVERGENi HBG002748.
KOi K16820.
OMAi HTGQRYF.
OrthoDBi EOG75MVW6.
TreeFami TF326941.

Enzyme and pathway databases

Reactomei REACT_194629. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_196408. PPARA activates gene expression.
REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_198809. Signaling by Hippo.

Miscellaneous databases

NextBioi 638920.
PROi Q4V7E6.

Gene expression databases

Genevestigatori Q4V7E6.

Family and domain databases

InterProi IPR001202. WW_dom.
[Graphical view ]
Pfami PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ4V7E6_RAT
AccessioniPrimary (citable) accession number: Q4V7E6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3