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Protein

Peptide chain release factor 1-like, mitochondrial

Gene

Mtrf1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1-like, mitochondrial
Alternative name(s):
Mitochondrial translational release factor 1-like
Gene namesi
Name:Mtrf1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1598312. Mtrf1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionSequence analysisAdd
BLAST
Chaini14 – 373360Peptide chain release factor 1-like, mitochondrialPRO_0000330946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451N5-methylglutamineBy similarity

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ4V7E5.
PRIDEiQ4V7E5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018773.
GenevisibleiQ4V7E5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025398.

Structurei

3D structure databases

ProteinModelPortaliQ4V7E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 11156Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiQ4V7E5.
KOiK02835.
OMAiDVRIDFF.
OrthoDBiEOG091G0O7T.
PhylomeDBiQ4V7E5.
TreeFamiTF313720.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V7E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGFLRSAR RLWARRAISR MPPPSEELLA RGGPLRAFLE RRVGSEAGGL
60 70 80 90 100
DAGSPQLAAA ARLLNEKERE LRDTESLLHD ENEDLKKLAE SEIALCQKEI
110 120 130 140 150
AELKHRIISL LVPSEDMDGS DLILEVTAGV GGQEAMLFTS EMFDMYQQYA
160 170 180 190 200
AFKRWHFETL EYFPSELGGL RHASASIGGP EAYRHMKFEG GVHRVQRVPK
210 220 230 240 250
TERQGRIHTS TMTVAILPQP TEIKLVINPK DLRIDTKRAS GAGGQHVNTT
260 270 280 290 300
DSAVRIVHLP TGIISECQQE RSQLKNRELA MKKLRARLYS MRLEEETAKR
310 320 330 340 350
YSARKIQVGT KGRSEKIRTY NFPQNRVTDH RINKSLHDLE SFMQGDCLLD
360 370
DLIQSLKDYS DYESLVEMIS RKD
Length:373
Mass (Da):42,343
Last modified:July 5, 2005 - v1
Checksum:i3399053A62C1B9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097970 mRNA. Translation: AAH97970.1.
RefSeqiNP_001020894.1. NM_001025723.1.
UniGeneiRn.205194.

Genome annotation databases

EnsembliENSRNOT00000025398; ENSRNOP00000025398; ENSRNOG00000018773.
GeneIDi361473.
KEGGirno:361473.
UCSCiRGD:1598312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097970 mRNA. Translation: AAH97970.1.
RefSeqiNP_001020894.1. NM_001025723.1.
UniGeneiRn.205194.

3D structure databases

ProteinModelPortaliQ4V7E5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025398.

Proteomic databases

PaxDbiQ4V7E5.
PRIDEiQ4V7E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025398; ENSRNOP00000025398; ENSRNOG00000018773.
GeneIDi361473.
KEGGirno:361473.
UCSCiRGD:1598312. rat.

Organism-specific databases

CTDi54516.
RGDi1598312. Mtrf1l.

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiQ4V7E5.
KOiK02835.
OMAiDVRIDFF.
OrthoDBiEOG091G0O7T.
PhylomeDBiQ4V7E5.
TreeFamiTF313720.

Enzyme and pathway databases

ReactomeiR-RNO-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ4V7E5.

Gene expression databases

BgeeiENSRNOG00000018773.
GenevisibleiQ4V7E5. RN.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1ML_RAT
AccessioniPrimary (citable) accession number: Q4V7E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.