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Protein

ETS-related transcription factor Elf-3

Gene

Elf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi297 – 379ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Inflammatory response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-3
Alternative name(s):
E74-like factor 3
Gene namesi
Name:Elf3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310687. Elf3.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus PROSITE-ProRule annotationBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876831 – 395ETS-related transcription factor Elf-3Add BLAST395

Proteomic databases

PaxDbiQ4V7E1.

PTM databases

iPTMnetiQ4V7E1.
PhosphoSitePlusiQ4V7E1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006330.
GenevisibleiQ4V7E1. RN.

Interactioni

Subunit structurei

Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008753.

Structurei

3D structure databases

ProteinModelPortaliQ4V7E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 155PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ4V7E1.
KOiK09429.
OMAiRDGFPDY.
OrthoDBiEOG091G0BE6.
PhylomeDBiQ4V7E1.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR033074. Elf3.
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF13. PTHR11849:SF13. 3 hits.
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V7E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATCEISNV FSNYFNAMYS SEDPTLAPAP LTTFGTEDFV LTLNNQHMSP
60 70 80 90 100
EGPVGCVGPQ TRSQRDRTEP PAVLHLAEKA SWTGERPQFW SKTQVLDWIS
110 120 130 140 150
YQVEKNKYDA SSIDFSRCDM DGATLCNCAL EELRLVFGPL GDQLHAQLRD
160 170 180 190 200
LTSSSSDELS WIIELLEKDG MTFQEGLGDS GPFDQGSPFA QELLDDGRQA
210 220 230 240 250
SPYYGSSYGP GAPSPGSSDF STSGTDTPQS SHSSDSGGSD VDLDLTDSKV
260 270 280 290 300
FPRDGFPDYK KGEPKHGKRK RGRPRKLSKE YWDCLEGKKS KHAPRGTHLW
310 320 330 340 350
EFIRDILIHP ELNEGLMKWE NRHEGVFKFL RSEAVAQLWG QKKKNSNMTY
360 370 380 390
EKLSRAMRYY YKREILERVD GRRLVYKFGK NSSGWKEEEV GESQN
Length:395
Mass (Da):44,521
Last modified:July 5, 2005 - v1
Checksum:iBBE321B85A73458A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097980 mRNA. Translation: AAH97980.1.
RefSeqiNP_001019939.1. NM_001024768.1.
UniGeneiRn.3063.

Genome annotation databases

EnsembliENSRNOT00000008754; ENSRNOP00000008753; ENSRNOG00000006330.
GeneIDi304815.
KEGGirno:304815.
UCSCiRGD:1310687. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097980 mRNA. Translation: AAH97980.1.
RefSeqiNP_001019939.1. NM_001024768.1.
UniGeneiRn.3063.

3D structure databases

ProteinModelPortaliQ4V7E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008753.

PTM databases

iPTMnetiQ4V7E1.
PhosphoSitePlusiQ4V7E1.

Proteomic databases

PaxDbiQ4V7E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008754; ENSRNOP00000008753; ENSRNOG00000006330.
GeneIDi304815.
KEGGirno:304815.
UCSCiRGD:1310687. rat.

Organism-specific databases

CTDi1999.
RGDi1310687. Elf3.

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ4V7E1.
KOiK09429.
OMAiRDGFPDY.
OrthoDBiEOG091G0BE6.
PhylomeDBiQ4V7E1.
TreeFamiTF318679.

Miscellaneous databases

PROiQ4V7E1.

Gene expression databases

BgeeiENSRNOG00000006330.
GenevisibleiQ4V7E1. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR033074. Elf3.
IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF13. PTHR11849:SF13. 3 hits.
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELF3_RAT
AccessioniPrimary (citable) accession number: Q4V7E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.