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Protein

ETS-related transcription factor Elf-3

Gene

Elf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi297 – 379ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Inflammatory response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-1912408 Pre-NOTCH Transcription and Translation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-3
Alternative name(s):
E74-like factor 3
Gene namesi
Name:Elf3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310687 Elf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876831 – 395ETS-related transcription factor Elf-3Add BLAST395

Proteomic databases

PaxDbiQ4V7E1

PTM databases

iPTMnetiQ4V7E1
PhosphoSitePlusiQ4V7E1

Expressioni

Gene expression databases

BgeeiENSRNOG00000006330
GenevisibleiQ4V7E1 RN

Interactioni

Subunit structurei

Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008753

Structurei

3D structure databases

ProteinModelPortaliQ4V7E1
SMRiQ4V7E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 155PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000232188
HOVERGENiHBG074143
InParanoidiQ4V7E1
KOiK09429
OMAiRDGFPDY
OrthoDBiEOG091G0BE6
PhylomeDBiQ4V7E1
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033074 Elf3
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF13 PTHR11849:SF13, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V7E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATCEISNV FSNYFNAMYS SEDPTLAPAP LTTFGTEDFV LTLNNQHMSP
60 70 80 90 100
EGPVGCVGPQ TRSQRDRTEP PAVLHLAEKA SWTGERPQFW SKTQVLDWIS
110 120 130 140 150
YQVEKNKYDA SSIDFSRCDM DGATLCNCAL EELRLVFGPL GDQLHAQLRD
160 170 180 190 200
LTSSSSDELS WIIELLEKDG MTFQEGLGDS GPFDQGSPFA QELLDDGRQA
210 220 230 240 250
SPYYGSSYGP GAPSPGSSDF STSGTDTPQS SHSSDSGGSD VDLDLTDSKV
260 270 280 290 300
FPRDGFPDYK KGEPKHGKRK RGRPRKLSKE YWDCLEGKKS KHAPRGTHLW
310 320 330 340 350
EFIRDILIHP ELNEGLMKWE NRHEGVFKFL RSEAVAQLWG QKKKNSNMTY
360 370 380 390
EKLSRAMRYY YKREILERVD GRRLVYKFGK NSSGWKEEEV GESQN
Length:395
Mass (Da):44,521
Last modified:July 5, 2005 - v1
Checksum:iBBE321B85A73458A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097980 mRNA Translation: AAH97980.1
RefSeqiNP_001019939.1, NM_001024768.1
UniGeneiRn.3063

Genome annotation databases

EnsembliENSRNOT00000008754; ENSRNOP00000008753; ENSRNOG00000006330
GeneIDi304815
KEGGirno:304815
UCSCiRGD:1310687 rat

Similar proteinsi

Entry informationi

Entry nameiELF3_RAT
AccessioniPrimary (citable) accession number: Q4V7E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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