Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NIF3-like protein 1

Gene

Nif3l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 11 Publication
Gene namesi
Name:Nif3l1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1310329. Nif3l1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Interaction with COPS2 may regulate localization to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376NIF3-like protein 1PRO_0000330909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081N6-acetyllysineBy similarity
Modified residuei254 – 2541PhosphothreonineBy similarity
Modified residuei258 – 2581PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4V7D6.
PRIDEiQ4V7D6.

PTM databases

iPTMnetiQ4V7D6.
PhosphoSiteiQ4V7D6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013446.
ExpressionAtlasiQ4V7D6. baseline.
GenevisibleiQ4V7D6. RN.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with COPS2 (PubMed:12522100). Interacts with THOC7 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018014.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni243 – 376134Mediates interaction with COPS2By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ4V7D6.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
PhylomeDBiQ4V7D6.
TreeFamiTF324125.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V7D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSAHVVPT SVRRAPSWIC SSSRSFMDLK ALLSSLNDFA SLSFAESWDN
60 70 80 90 100
VGLLVEPSPP HTVNTLFLTN DLTEEVMEEA LQKKADLILS YHPPIFRPMK
110 120 130 140 150
HITWKTWKER LVIRALENRV AIYSPHTAYD AAPQGVNSWL AKGLGTCTTR
160 170 180 190 200
PIHPSKAPNY PTEGTHRLEF SANHSQDLDK VMSAVKGVGG VSVTSFPARC
210 220 230 240 250
DGEEQTRVSL NCTQKALMQV LAFLSQDRQL YQKTEILSLE KPLLLHTGMG
260 270 280 290 300
RLCTLDESVS LATMIERIKR HLKLPHLRLA LGVGRTLESP VKVVALCAGS
310 320 330 340 350
GGSVLQGVEA DLYLTGEMSH HDVLDAASKG INVILCEHSN TERGFLSDLQ
360 370
EMLGVHLENK INIILSETDR DPLRVV
Length:376
Mass (Da):41,519
Last modified:July 5, 2005 - v1
Checksum:i026B28FA7CC412B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097992 mRNA. Translation: AAH97992.1.
RefSeqiXP_006245023.1. XM_006244961.2.
XP_006245024.1. XM_006244962.2.
UniGeneiRn.229097.

Genome annotation databases

EnsembliENSRNOT00000018014; ENSRNOP00000018014; ENSRNOG00000013446.
GeneIDi301431.
UCSCiRGD:1310329. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097992 mRNA. Translation: AAH97992.1.
RefSeqiXP_006245023.1. XM_006244961.2.
XP_006245024.1. XM_006244962.2.
UniGeneiRn.229097.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018014.

PTM databases

iPTMnetiQ4V7D6.
PhosphoSiteiQ4V7D6.

Proteomic databases

PaxDbiQ4V7D6.
PRIDEiQ4V7D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018014; ENSRNOP00000018014; ENSRNOG00000013446.
GeneIDi301431.
UCSCiRGD:1310329. rat.

Organism-specific databases

CTDi60491.
RGDi1310329. Nif3l1.

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ4V7D6.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
PhylomeDBiQ4V7D6.
TreeFamiTF324125.

Miscellaneous databases

PROiQ4V7D6.

Gene expression databases

BgeeiENSRNOG00000013446.
ExpressionAtlasiQ4V7D6. baseline.
GenevisibleiQ4V7D6. RN.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIF3L_RAT
AccessioniPrimary (citable) accession number: Q4V7D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.