WD repeat-containing protein 61 - Rattus norvegicus (Rat)

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Q4V7A0 (WDR61_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 61

Gene names

Name:

Wdr61

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C By similarity.
Subunit structure	Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Contains 7 WD repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW histone H3-K4 trimethylation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of myeloid cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of histone H3-K4 methylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of histone H3-K79 methylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription elongation from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Cdc73/Paf1 complex Inferred from sequence or structural similarity. Source: UniProtKB Ski complex Inferred from sequence or structural similarity. Source: UniProtKB transcriptionally active chromatin Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 305

304

WD repeat-containing protein 61

PRO_0000245853

Regions

Repeat

14 – 57

WD 1

Repeat

62 – 101

WD 2

Repeat

104 – 143

WD 3

Repeat

146 – 187

WD 4

Repeat

188 – 227

WD 5

Repeat

230 – 269

WD 6

Repeat

272 – 305

WD 7

Amino acid modifications

Modified residue

N-acetylthreonine Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q4V7A0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 02EB895CA3C7E181
Show »

FASTA

305

33,747

        10         20         30         40         50         60 
MTNQYSILFK QEQAHDDAIW SVAWETNKKE NIETVVTGSL DDLVKVWKWR DERLELQWSL 

        70         80         90        100        110        120 
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQMK SIDAGPVDAW TLAFSPDSQH 

       130        140        150        160        170        180 
LATGTHMGKV NIFGVESGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG 

       190        200        210        220        230        240 
KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF 

       250        260        270        280        290        300 
CPDDTHFVSS SSDKSVKVWD VGTRTCIHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHV 


YDCPI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	Lubec G., Chen W.-Q. Submitted (FEB-2007) to UniProtKB Cited for: ACETYLATION AT THR-2, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098059 mRNA. Translation: AAH98059.1.
IPI	IPI00366523.
RefSeq	NP_001020914.1. NM_001025743.1.
UniGene	Rn.3698.
3D structure databases
ProteinModelPortal	Q4V7A0.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000059282.
Proteomic databases
PaxDb	Q4V7A0.
PRIDE	Q4V7A0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000017239; ENSRNOP00000017239; ENSRNOG00000012803.
GeneID	363064.
KEGG	rno:363064.
UCSC	RGD:1308228. rat.
Organism-specific databases
CTD	80349.
RGD	1308228. Wdr61.
Phylogenomic databases
eggNOG	COG2319.
GeneTree	ENSGT00700000104507.
HOGENOM	HOG000036765.
HOVERGEN	HBG059813.
InParanoid	Q4V7A0.
KO	K12602.
OrthoDB	EOG4VMFFW.
Gene expression databases
ArrayExpress	Q4V7A0.
Genevestigator	Q4V7A0.
GermOnline	ENSRNOG00000012803. Rattus norvegicus.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	682300.

Entry information

Entry name

WDR61_RAT

Accession

Primary (citable) accession number: Q4V7A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents