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Q4V7A0

- WDR61_RAT

UniProt

Q4V7A0 - WDR61_RAT

Protein

WD repeat-containing protein 61

Gene

Wdr61

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C By similarity.By similarity

    GO - Biological processi

    1. histone H3-K4 trimethylation Source: UniProtKB
    2. negative regulation of myeloid cell differentiation Source: UniProtKB
    3. positive regulation of histone H3-K4 methylation Source: UniProtKB
    4. positive regulation of histone H3-K79 methylation Source: UniProtKB
    5. positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW
    8. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 61
    Cleaved into the following chain:
    Gene namesi
    Name:Wdr61
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1308228. Wdr61.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. Cdc73/Paf1 complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. Ski complex Source: UniProtKB
    5. transcriptionally active chromatin Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305WD repeat-containing protein 61PRO_0000425750Add
    BLAST
    Initiator methioninei1 – 11Removed; alternate1 Publication
    Chaini2 – 305304WD repeat-containing protein 61, N-terminally processedPRO_0000245853Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ4V7A0.
    PRIDEiQ4V7A0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4V7A0.

    Interactioni

    Subunit structurei

    Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000059282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4V7A0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati14 – 5744WD 1Add
    BLAST
    Repeati62 – 10140WD 2Add
    BLAST
    Repeati104 – 14340WD 3Add
    BLAST
    Repeati146 – 18742WD 4Add
    BLAST
    Repeati188 – 22740WD 5Add
    BLAST
    Repeati230 – 26940WD 6Add
    BLAST
    Repeati272 – 30534WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115515.
    HOGENOMiHOG000036765.
    HOVERGENiHBG059813.
    InParanoidiQ4V7A0.
    KOiK12602.
    OMAiMPVRSMV.
    OrthoDBiEOG7KM5T5.
    PhylomeDBiQ4V7A0.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 6 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4V7A0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNQYSILFK QEQAHDDAIW SVAWETNKKE NIETVVTGSL DDLVKVWKWR    50
    DERLELQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQMK 100
    SIDAGPVDAW TLAFSPDSQH LATGTHMGKV NIFGVESGKK EYSLDTRGKF 150
    ILSIAYSPDG KYLASGAIDG IINIFDIATG KLLHTLEGHA MPIRSLTFSP 200
    DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF CPDDTHFVSS 250
    SSDKSVKVWD VGTRTCIHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHV 300
    YDCPI 305
    Length:305
    Mass (Da):33,747
    Last modified:July 5, 2005 - v1
    Checksum:i02EB895CA3C7E181
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098059 mRNA. Translation: AAH98059.1.
    RefSeqiNP_001020914.1. NM_001025743.1.
    XP_006243147.1. XM_006243085.1.
    XP_006243148.1. XM_006243086.1.
    UniGeneiRn.3698.

    Genome annotation databases

    EnsembliENSRNOT00000017239; ENSRNOP00000017239; ENSRNOG00000012803.
    GeneIDi363064.
    KEGGirno:363064.
    UCSCiRGD:1308228. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098059 mRNA. Translation: AAH98059.1 .
    RefSeqi NP_001020914.1. NM_001025743.1.
    XP_006243147.1. XM_006243085.1.
    XP_006243148.1. XM_006243086.1.
    UniGenei Rn.3698.

    3D structure databases

    ProteinModelPortali Q4V7A0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000059282.

    Proteomic databases

    PaxDbi Q4V7A0.
    PRIDEi Q4V7A0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017239 ; ENSRNOP00000017239 ; ENSRNOG00000012803 .
    GeneIDi 363064.
    KEGGi rno:363064.
    UCSCi RGD:1308228. rat.

    Organism-specific databases

    CTDi 80349.
    RGDi 1308228. Wdr61.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115515.
    HOGENOMi HOG000036765.
    HOVERGENi HBG059813.
    InParanoidi Q4V7A0.
    KOi K12602.
    OMAi MPVRSMV.
    OrthoDBi EOG7KM5T5.
    PhylomeDBi Q4V7A0.

    Miscellaneous databases

    NextBioi 682300.

    Gene expression databases

    Genevestigatori Q4V7A0.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 6 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. Lubec G., Chen W.-Q.
      Submitted (FEB-2007) to UniProtKB
      Cited for: ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiWDR61_RAT
    AccessioniPrimary (citable) accession number: Q4V7A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3