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Q4V7A0

- WDR61_RAT

UniProt

Q4V7A0 - WDR61_RAT

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Protein

WD repeat-containing protein 61

Gene

Wdr61

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (By similarity).By similarity

GO - Biological processi

  1. histone H3-K4 trimethylation Source: UniProtKB
  2. negative regulation of myeloid cell differentiation Source: UniProtKB
  3. positive regulation of histone H3-K4 methylation Source: UniProtKB
  4. positive regulation of histone H3-K79 methylation Source: UniProtKB
  5. positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
  6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 61
Cleaved into the following chain:
Gene namesi
Name:Wdr61
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1308228. Wdr61.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. Cdc73/Paf1 complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. Ski complex Source: UniProtKB
  5. transcriptionally active chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305WD repeat-containing protein 61PRO_0000425750Add
BLAST
Initiator methioninei1 – 11Removed; alternate1 Publication
Chaini2 – 305304WD repeat-containing protein 61, N-terminally processedPRO_0000245853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processed1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4V7A0.
PRIDEiQ4V7A0.

Expressioni

Gene expression databases

GenevestigatoriQ4V7A0.

Interactioni

Subunit structurei

Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059282.

Structurei

3D structure databases

ProteinModelPortaliQ4V7A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 5744WD 1Add
BLAST
Repeati62 – 10140WD 2Add
BLAST
Repeati104 – 14340WD 3Add
BLAST
Repeati146 – 18742WD 4Add
BLAST
Repeati188 – 22740WD 5Add
BLAST
Repeati230 – 26940WD 6Add
BLAST
Repeati272 – 30534WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000118869.
HOGENOMiHOG000036765.
HOVERGENiHBG059813.
InParanoidiQ4V7A0.
KOiK12602.
OMAiMPVRSMV.
OrthoDBiEOG7KM5T5.
PhylomeDBiQ4V7A0.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V7A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNQYSILFK QEQAHDDAIW SVAWETNKKE NIETVVTGSL DDLVKVWKWR
60 70 80 90 100
DERLELQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQMK
110 120 130 140 150
SIDAGPVDAW TLAFSPDSQH LATGTHMGKV NIFGVESGKK EYSLDTRGKF
160 170 180 190 200
ILSIAYSPDG KYLASGAIDG IINIFDIATG KLLHTLEGHA MPIRSLTFSP
210 220 230 240 250
DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF CPDDTHFVSS
260 270 280 290 300
SSDKSVKVWD VGTRTCIHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHV

YDCPI
Length:305
Mass (Da):33,747
Last modified:July 5, 2005 - v1
Checksum:i02EB895CA3C7E181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098059 mRNA. Translation: AAH98059.1.
RefSeqiNP_001020914.1. NM_001025743.1.
XP_006243147.1. XM_006243085.2.
XP_006243148.1. XM_006243086.2.
UniGeneiRn.3698.

Genome annotation databases

EnsembliENSRNOT00000017239; ENSRNOP00000017239; ENSRNOG00000012803.
GeneIDi363064.
KEGGirno:363064.
UCSCiRGD:1308228. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098059 mRNA. Translation: AAH98059.1 .
RefSeqi NP_001020914.1. NM_001025743.1.
XP_006243147.1. XM_006243085.2.
XP_006243148.1. XM_006243086.2.
UniGenei Rn.3698.

3D structure databases

ProteinModelPortali Q4V7A0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000059282.

Proteomic databases

PaxDbi Q4V7A0.
PRIDEi Q4V7A0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017239 ; ENSRNOP00000017239 ; ENSRNOG00000012803 .
GeneIDi 363064.
KEGGi rno:363064.
UCSCi RGD:1308228. rat.

Organism-specific databases

CTDi 80349.
RGDi 1308228. Wdr61.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000118869.
HOGENOMi HOG000036765.
HOVERGENi HBG059813.
InParanoidi Q4V7A0.
KOi K12602.
OMAi MPVRSMV.
OrthoDBi EOG7KM5T5.
PhylomeDBi Q4V7A0.

Miscellaneous databases

NextBioi 682300.

Gene expression databases

Genevestigatori Q4V7A0.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 6 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Lubec G., Chen W.-Q.
    Submitted (FEB-2007) to UniProtKB
    Cited for: ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiWDR61_RAT
AccessioniPrimary (citable) accession number: Q4V7A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3