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Protein

Homeodomain-interacting protein kinase 4

Gene

Hipk4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).By similarityCurated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 4 (EC:2.7.11.1)
Gene namesi
Name:Hipk4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307541. Hipk4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324031 – 616Homeodomain-interacting protein kinase 4Add BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei512PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4V793.
PRIDEiQ4V793.

PTM databases

iPTMnetiQ4V793.
PhosphoSitePlusiQ4V793.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020835.
GenevisibleiQ4V793. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028266.

Structurei

3D structure databases

ProteinModelPortaliQ4V793.
SMRiQ4V793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 347Protein kinasePROSITE-ProRule annotationAdd BLAST337

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000090252.
HOVERGENiHBG081604.
InParanoidiQ4V793.
KOiK08826.
OMAiGPPYYRL.
OrthoDBiEOG091G04Y2.
PhylomeDBiQ4V793.
TreeFamiTF105417.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR
60 70 80 90 100
IIKNELKLLR CVRGLDPDEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ
110 120 130 140 150
KENNFAPLPA RHIRTVTLQV LRALARLKEL AIIHADLKPE NIMLVDQTRC
160 170 180 190 200
PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL PFCEKVDVWS
210 220 230 240 250
LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AARKAHHFFK
260 270 280 290 300
RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAV
310 320 330 340 350
NRLSFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ
360 370 380 390 400
QLRSAHEATR YYQLSLRGCR LSLQVDGKPP PPVIANAEDG PPYYRLAEEE
410 420 430 440 450
ETAGLGGVTG SGSFFREDKA PGMQRAIDQL DDLSLQEARR GLWSDTRADM
460 470 480 490 500
VSDMLAPLKV ATTSHRVPDS GPEPILAFYG SRLTGRHKAR KAPAGSKSDS
510 520 530 540 550
NFSNLIRLSQ ASPEDAGSCR GSGWEEGEGH TTSTEPSAIP QREGDGPSIK
560 570 580 590 600
DRPMDAERSG PELFDPSGCP GEWLNEPEWT LEGIRGSRAQ GLPARHPHPH
610
GPPRTTSFLQ HVGGHH
Length:616
Mass (Da):69,298
Last modified:July 5, 2005 - v1
Checksum:i12E14628743474AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098070 mRNA. Translation: AAH98070.1.
RefSeqiNP_001019947.1. NM_001024776.1.
UniGeneiRn.41008.

Genome annotation databases

EnsembliENSRNOT00000028266; ENSRNOP00000028266; ENSRNOG00000020835.
GeneIDi308449.
KEGGirno:308449.
UCSCiRGD:1307541. rat.

Similar proteinsi

Entry informationi

Entry nameiHIPK4_RAT
AccessioniPrimary (citable) accession number: Q4V793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2005
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families